Sepsis Treatment: New Antibiotic Dosing Strategy

We are testing a new way to dose beta-lactam antibiotics for critically ill patients with sepsis. The goal is to see if this improves their recovery in the ICU.

1-2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesInjectionInfectious DiseasesInternal MedicinePulmonology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Amoxicilline Cf
Amoxicilline Cf is an antibiotic medicine used to treat bacterial infections.
Amoxicilline/Clavulaanzuur Sandoz
Amoxicilline/Clavulaanzuur Sandoz is an antibiotic used to treat common bacterial infections like chest, ear, sinus, skin, and urinary tract infections.
Ceftazidim Fresenius Kabi
Ceftazidim Fresenius Kabi is an antibiotic used to treat serious bacterial infections, often given to patients in hospitals.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Amoxicillin
Amoxicillin is an antibiotic substance used to treat a range of common bacterial infections such as ear, throat, and urinary tract infections.
Amoxicillin Trihydrate
Amoxicillin trihydrate is an antibiotic substance used to treat common bacterial infections such as ear, throat, and urinary tract infections.
Cefotaxime
Cefotaxime is an antibiotic substance used to treat serious bacterial infections by stopping bacteria from growing.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Acipirin
Agenor
Agenor

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Stichting OLVG
Intensive Care
Amsterdam, Netherlands
Maasstad Ziekenhuis Stichting
Intensive Care
Barendrecht, Netherlands
Amphia Hospital
Intensive Care
Breda, Netherlands
Sponsor: Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.