Severe Acute Pain: ESKAPE Study on Low-Dose Ketamine

We are comparing two low-dose ketamine treatments for severe pain in the emergency department. The study looks at pain relief and any psychological effects patients may experience.

>2 years Monitoring phase (IV)No Placebo Standard Medicines InjectionInternal MedicineOtolaryngologyPsychiatry

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Esketamine Idd

Esketamine Idd is a medicine used to treat adults with hard-to-treat depression when other antidepressants haven't helped.

Ketamine Renaudin

Ketamine Renaudin is a medicine used to induce anesthesia and relieve severe pain.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Esketamine Hydrochloride

Esketamine hydrochloride is a fast-acting substance used to treat severe depression when other treatments haven’t worked.

Ketamine Hydrochloride

Ketamine hydrochloride is a substance that produces short-term anesthesia and pain relief for surgeries and severe pain.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Calypsol

Cetamina G.L. Pharma

Cetamina Hikma

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Centre Hospitalier Universitaire De Nice

Emergency unit

Nice, France

Sponsor: Centre Hospitalier Universitaire De Nice

Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.