Siponimod for Progressive Multiple Sclerosis

We are studying how siponimod affects brain lesions and nerve damage in patients with secondary progressive MS. The trial also looks at its impact on cognitive health and long-term safety.

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Mayzent
Mayzent is a medicine used to slow disability progression and reduce relapses in adults with relapsing multiple sclerosis.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Siponimod
Siponimod is a substance that alters immune cells to reduce relapses and slow disability in certain forms of multiple sclerosis.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Baf312

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Careggi University Hospital
Neurologia II
Florence, Italy
Azienda Ospedaliera Universitaria Integrata Verona
UOC Neurologia B
Verona, Italy
Sponsor: Azienda Ospedaliera Universitaria Integrata Verona
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.