Staphylococcal Joint Infection: Rifampicin vs. Clindamycin

We are studying whether a targeted antibiotic can effectively treat staphylococcal infections in joint prostheses compared to a traditional combination therapy. This trial also examines quality of life and any side effects experienced by participants.

1-2 yearsMonitoring phase (IV)No PlaceboInvestigational MedicinesOralInfectious DiseasesOrthopedics and Traumatology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Ciprofloxacin Ratiopharm
Ciprofloxacin Ratiopharm is an antibiotic medicine used to treat various bacterial infections, including urinary and respiratory tract infections.
Clindamycin 300 1 A Pharma
Clindamycin 300 1 A Pharma is an antibiotic medicine used to treat various bacterial infections such as skin, bone, and respiratory infections.
Doxycycline Disper Aurobindo
Doxycycline Disper Aurobindo is an antibiotic medicine used to treat various bacterial infections such as respiratory, skin, and urinary tract infections.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Ciprofloxacin Hydrochloride Monohydrate
Ciprofloxacin hydrochloride monohydrate is an antibiotic used to treat various bacterial infections, particularly urinary, respiratory, and skin infections.
Clindamycin
Clindamycin is an antibiotic substance used to treat various bacterial infections, including skin and respiratory infections.
Doxycycline
Doxycycline is an antibiotic substance used to treat a wide range of bacterial infections, including respiratory, skin, and tick-borne illnesses.

What experimental substances are being tested?

Experimental substances that are being investigated in this clinical trial. These are not yet approved for general use.

Minocycline
Cotrimoxazole

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abimox
Abiox
Acnatac

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

Loading map...
Amsterdam UMC
infectious diseases
Amstelveen, Netherlands
Stichting OLVG
orthopedics
Amsterdam, Netherlands
Gelre Hospitals
orthopedics
Apeldoorn, Netherlands
Sponsor: Leiden University Medical Center
Last updated: Nov 26, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.