Vertebral Osteomyelitis: Early Oral Antibiotics Study

We are investigating if switching to oral antibiotics after one week is as effective as continuing intravenous treatment for pyogenic vertebral osteomyelitis. This study will also assess safety, hospital stays, and quality of life for patients.

3-6 monthsMonitoring phase (IV)No PlaceboStandard MedicinesOralInjectionInfectious DiseasesOrthopedics and TraumatologyRheumatology

What diseases are being studied?

Health conditions and diseases that the clinical trial is designed to study and treat.

Who can participate in the clinical trial?

These questions help us understand your situation so we can let the trial team know whether you might be a potential match. This is not a medical evaluation and is not part of the official screening, the study doctor will make the final decision..

What medicines are being studied?

Medicines that are officially approved for use in the European Union and considered safe by EMA. These medicines are already on the market and may be tested for new conditions or populations.

Bactrim
Bactrim is an antibiotic used to treat a variety of bacterial infections, including urinary tract, ear, and respiratory infections.
Ceftriaxone
Ceftriaxone is an antibiotic used to treat serious bacterial infections such as pneumonia, meningitis, and severe bloodstream infections.
Cefuroxime
Cefuroxime is an antibiotic medicine used to treat common bacterial infections of the lungs, sinuses, skin, and urinary tract.

What active substances are being studied?

Active substances that are officially approved for use in the European Union and considered safe by EMA. These substances are already on the market and may be tested for new conditions or populations.

Amoxicillin
Amoxicillin is an antibiotic substance used to treat a range of common bacterial infections such as ear, throat, and urinary tract infections.
Ampicillin
Ampicillin is an antibiotic substance used to treat various bacterial infections.
Benzylpenicillin
Benzylpenicillin is an antibiotic substance used to treat various serious bacterial infections.

What similar medicines might you know?

Don't worry if you don't know the medicines tested in the trial. There is a chance you have heard about the similar medicines. Check the list below to see if you are familiar with any of them.

Abimox
Abiox
Actacillin

Where is the clinical trial being conducted?

Locations and medical facilities where this clinical trial is currently recruiting or conducting research. Select the locations where you would like to participate.

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Aalborg University Hospital
Infectious Diseases
Aalborg, Denmark
Aarhus Universitetshospital
Infectious Diseases
Århus, Denmark
Rigshospitalet
Infectious Diseases
Copenhagen, Denmark

Sponsor: Rigshospitalet
Last updated: Nov 27, 2025

Disclaimer: Parts of this content have been automatically extracted from the EU Clinical Trials registry. While we strive for accuracy, please always contact the trial site or sponsor directly for correct and official information before making any decisions about participation. View on EU Clinical Trials.