Search Clinical Trials in the European Union

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1321-1340 of 2,120 trials

Neurodegenerative Disorders: Tau PET Imaging Study

We are exploring a new imaging method to identify early signs of neurodegenerative diseases in at-risk individuals. The study aims to understand how tau protein relates to cognitive changes and different types of dementia.

Neurodegenerative Diseases>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesNeurology

Advanced Sarcoma: NKG2D CAR-T Cell Therapy

We are testing a new type of immune cell therapy for children and young adults with advanced sarcoma. The study aims to see if this treatment is safe and effective in reducing tumor size.

Sarcoma>2 yearsSafety phase (I)No PlaceboInvestigational MedicinesOncology

Peritonitis Treatment: Pentaglobin® Study

We are investigating whether Pentaglobin® can improve organ function and reduce the risk of death in patients recovering from peritonitis. This study looks at changes in health over time after infection control.

SepsisSeptic ShockSeptic Peritonitis3-6 monthsEfficacy phase (II)No PlaceboStandard MedicinesInfectious DiseasesInternal Medicine

Crohn’s Disease and Ulcerative Colitis: Tulisokibart Study

We are studying the long-term safety and effectiveness of tulisokibart in people with Crohn’s disease or ulcerative colitis. This research aims to see how well the treatment helps manage symptoms and achieve remission.

Crohn's DiseaseUlcerative Colitis>2 yearsConfirmation phase (III)>20 visitsPost-Trial Drug AccessInvestigational MedicinesGastroenterologyInternal Medicine

Polymyalgia Rheumatica: Rituximab Study

We are investigating whether rituximab can help reduce the need for corticosteroids in people with relapsing polymyalgia rheumatica. This study compares rituximab to a placebo to assess its effectiveness.

Polymyalgia Rheumatica1-2 yearsMonitoring phase (IV)6-10 visitsStandard MedicinesCost ReimbursementPartially RemoteGastroenterologyRheumatology

Glioblastoma Treatment: Optune with Pembrolizumab

We are testing whether adding pembrolizumab to Optune and temozolomide improves survival for newly diagnosed glioblastoma patients compared to a placebo. This study aims to understand the effectiveness and safety of this treatment combination.

Newly Diagnosed Glioblastoma>2 yearsConfirmation phase (III)Standard MedicinesOncology

Gastric Bypass Surgery: Tranexamic Acid Study

We are investigating whether giving Tranexamic acid during gastric bypass surgery helps reduce bleeding in patients with morbid obesity. This could lead to safer surgical procedures.

Morbid Obesity1-2 yearsConfirmation phase (III)No PlaceboStandard MedicinesInternal MedicineOrthopedics and Traumatology

Hernia Repair: Comparing Pain Relief Techniques

We are studying whether giving a specific pain relief injection before or after hernia surgery helps reduce chronic pain and the need for pain medications. This trial is for patients undergoing open inguinal hernia mesh repair.

Chronic Pain After Hernia Surgery1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOrthopedics and Traumatology

YTB323 for Treatment-Resistant Generalized Myasthenia Gravis

We are studying the safety and effects of YTB323 in patients with treatment-resistant generalized myasthenia gravis. This research aims to understand how the drug works in the body and its potential to improve symptoms.

Myasthenia Gravis1-2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementInternal MedicineNeurology

Cytoreductive Surgery: HiPRESS Study

We are testing if low-dose argipressin can reduce fluid use and improve recovery during surgery for cancer treatment. This study compares it to standard treatment to see which is better for patients.

Disseminated Cancer≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyInternal MedicineOrthopedics and Traumatology

Frozen Embryo Transfer: The Role of Corpus Luteum

We are studying how the presence of the corpus luteum affects pregnancies from frozen embryo transfers. This research may help us understand its impact on maternal and fetal health.

Infertility6-12 monthsMonitoring phase (IV)11-15 visitsNo PlaceboStandard MedicinesGynecology and Obstetrics

Ataxia Telangiectasia: EryDex Safety Study

We are assessing the safety and tolerability of EryDex in individuals with Ataxia Telangiectasia. Additionally, we’re exploring its potential effects on neurological symptoms.

Ataxia Telangiectasia (A-T)1-2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteInternal MedicineNeurology

Advanced Lung Cancer: Eftilagimod Alfa with Pembrolizumab

We are studying a new drug, eftilagimod alfa, combined with pembrolizumab and chemotherapy for patients with advanced non-small cell lung cancer. The goal is to see if this combination works better than standard treatments.

Advanced Non-Small Cell Lung Cancer>2 yearsConfirmation phase (III)Investigational MedicinesCost ReimbursementPartially RemoteOncology

Advanced Solid Tumors: MCLA-158 (Petosemtamab) Study

We are testing a new treatment called MCLA-158 for people with advanced solid tumors to see how well it works and how safe it is. This study looks at its effects alone and in combination with other therapies.

Metastatic Colorectal CancerMalignant Solid TumorSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesOncology

Skin Cancer Treatment: Nivolumab and Relatlimab Study

We are studying the effects of Nivolumab alone and in combination with Relatlimab for patients with advanced squamous cell carcinoma of the skin. This trial aims to find out which treatment may help control the disease better.

Locally Advanced/Metastatic Squamous Cell Carcinoma of the Skin>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesDermatologyOncology

Palmo-Plantars Warts: HPV Vaccine Study

We are testing a nonavalent HPV vaccine to see if it helps people with difficult-to-treat warts on their hands and feet. The study aims to improve wart clearance, pain, and overall quality of life.

HPV Vaccine>2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesPartially RemoteDermatologyInfectious Diseases

Obesity: PF-07976016 Medication Study

We are testing a new medication called PF-07976016 to see if it helps adults with obesity lose weight more effectively than a placebo. The study also looks at the safety of this medication for those already taking liraglutide.

ObesityOverweight6-12 monthsEfficacy phase (II)6-10 visitsInvestigational MedicinesPartially RemoteDiabetologyEndocrinology

Lung Cancer Treatment: Nivolumab + Relatlimab with Chemotherapy

We are studying if a new combination treatment helps people with advanced non-small cell lung cancer live longer compared to standard treatment. This trial is for those whose cancer has spread or returned after previous treatment.

Advanced Non-Small Cell Lung Cancer>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementOncology

Immunotherapy for Advanced Cancer: Standard vs. Reduced Dose

We are comparing standard immunotherapy treatment with a less frequent dosing schedule for patients with advanced cancer. The goal is to see if the reduced dose is just as effective and to evaluate its impact on quality of life and safety.

Advanced or Metastatic Cancer>2 yearsConfirmation phase (III)11-15 visitsNo PlaceboStandard MedicinesOncology

Triple-Negative Breast Cancer: Ceralasertib with Durvalumab and Nab-Paclitaxel

We are studying a new treatment approach for patients with advanced triple-negative breast cancer who have relapsed after prior therapies. This trial aims to see if combining ceralasertib with other medications can improve their response to treatment.

Advanced Triple Negative Breast Cancer>2 yearsEfficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesOncology