Search Clinical Trials in the European Union

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1361-1380 of 1,694 trials

Type 2 Diabetes: Personalized Treatment Study

We are exploring how different diabetes medications work for patients based on their insulin response. The goal is to find biomarkers that help tailor treatments for better management of type 2 diabetes.

Type 2 Diabetes1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesEndocrinologyInternal Medicine

Rectal Cancer: REGorafenib and Nivolumab Treatment

We are studying a new treatment combining REGorafenib and Nivolumab with short-course radiotherapy for patients with intermediate-risk rectal cancer. The aim is to see if this approach improves treatment response and safety before surgery.

Locally-advanced Rectal Cancer>2 yearsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesOncology

Clenbuterol for Spinal and Bulbar Muscular Atrophy (SBMA)

We are studying whether clenbuterol can help patients with SBMA manage their symptoms. We will also look at how well patients tolerate the treatment over time.

Spinal and Bulbar Muscular Atrophy6-12 monthsEfficacy phase (II)6-10 visitsInvestigational MedicinesInternal MedicineNeurology

Clebopride for the Treatment of Rumination Syndrome

We are studying whether clebopride can improve symptoms in people suspected of having rumination syndrome. The trial compares its effects to a placebo to see how well it works.

Rumination Syndrome≤3 monthsMonitoring phase (IV)≤5 visitsInvestigational MedicinesCost ReimbursementPartially RemoteGastroenterology

Bipolar Disorder: Low-Dose Aspirin Study

We are investigating whether adding low-dose aspirin to standard treatment helps improve symptoms in patients with bipolar disorder. This study aims to assess both the effectiveness and safety of this approach.

Bipolar Disorder1-2 yearsEfficacy phase (II)Standard MedicinesPartially RemotePsychiatry

Melanoma with Brain Metastases: Immunotherapy Study

We are studying the effects of immunotherapy in melanoma patients with brain metastases who are also receiving steroid treatment. Our goal is to see if this combination improves outcomes compared to standard care.

Malignant Melanoma of Skin1-2 yearsEfficacy phase (II)11-15 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesNeurologyOncology

Chronic Kidney Disease: Optimizing Tacrolimus Dosage with Genetic Testing

We are studying whether a genetic testing strategy can help tailor tacrolimus dosing for patients with chronic kidney disease before kidney transplantation. This may improve treatment outcomes and reduce side effects.

Kidney Transplant1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboInvestigational MedicinesInternal MedicineNephrology

Diabetic Cardiovascular Autonomic Neuropathy: The FibroCAN Study

We are investigating whether finerenone can help improve heart function and reduce nerve damage in people with type 2 diabetes and early-stage cardiovascular autonomic neuropathy. This study compares the treatment to a placebo to assess its effects.

Diabetic Cardiovascular Autonomic Neuropathy1-2 yearsEfficacy phase (II)6-10 visitsInvestigational MedicinesCost ReimbursementCardiologyEndocrinologyNeurology

Advanced Solid Tumors: BMS-986482 Study

We are investigating the safety and dosage of BMS-986482 alone or with other therapies for patients with advanced solid tumors. This study aims to understand how well it works in combination with existing treatments.

Advanced Solid Tumors>2 yearsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteOncology

Nodal T Cell Lymphoma: Duvelisib vs. Gemcitabine or Bendamustine

We are studying whether duvelisib can improve outcomes for patients with relapsed or refractory nodal T cell lymphoma. This trial compares its effects to standard treatments like gemcitabine or bendamustine.

Refractory Adult T-cell LymphomaRelapsed/Refractory Nodal T Cell Lymphoma with TFH Phenotype>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesHematologyOncology

Crizotinib for Children with Severe Type 2 Neurofibromatosis

We are studying whether crizotinib can help reduce tumor size in children with severe type 2 neurofibromatosis who are not eligible for surgery or radiotherapy. We will also evaluate the safety of this treatment.

Neurofibromatosis Type 21-2 yearsEfficacy phase (II)16-20 visitsNo PlaceboStandard MedicinesNeurologyOncology

Kidney Transplant in Children: Prolonged-Release Tacrolimus Study

We are studying a new form of tacrolimus for children who have undergone kidney transplantation. The goal is to see if it works as well and is as safe as the current version used.

Caucasian Pediatric Kidney Transplant Recipients1-2 yearsEfficacy phase (II)Confirmation phase (III)No PlaceboStandard MedicinesNephrologyPediatrics

Gastroenteropancreatic and Thoracic Neuroendocrine Tumors: Cabozantinib and Lanreotide Study

We are studying the safety and effectiveness of a new combination treatment for patients with gastroenteropancreatic and thoracic neuroendocrine tumors. This trial aims to find out if this combination can improve treatment outcomes compared to current options.

Gastroenteropancreatic and Thoracic Neuroendocrine TumorEfficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesEndocrinologyOncology

Acromegaly: Debio 4126 Treatment Study

We are testing a new formulation of Debio 4126 in patients with acromegaly who have been treated with other medications. The study aims to see if it helps maintain normal hormone levels and evaluates its safety compared to a placebo.

Acromegaly1-2 yearsConfirmation phase (III)>20 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementEndocrinology

Cardiovascular Health in Type 2 Diabetes: COLCOT-T2D Study

We are studying whether colchicine and non-enteric coated aspirin can improve heart health in high-risk adults with type 2 diabetes. The goal is to see if these treatments can reduce serious heart-related events.

Unspecified Cardiovascular DiseaseConfirmation phase (III)6-10 visitsInvestigational MedicinesPartially RemoteCardiologyEndocrinology

Pain Medication Tapering for Persistent Spinal Pain

We are studying how different methods of reducing pain medication affect disability in patients with Persistent Spinal Pain Syndrome Type II after spinal cord stimulation. This research may help improve pain management strategies.

Persistent Spinal Pain Syndrome Type II1-2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesPartially RemoteInternal MedicineNeurologyOrthopedics and Traumatology

Ovarian Cancer: NIraparib and Dostarlimab Study

We are testing a new treatment combination for patients with recurrent ovarian cancer who cannot have platinum therapy. The study aims to see if this combination helps patients live longer compared to standard chemotherapy.

Recurrent Ovarian CancerConfirmation phase (III)No PlaceboStandard MedicinesGynecology and ObstetricsOncology

Melanoma Treatment: Vemurafenib, Cobimetinib, and Atezolizumab

We are studying a combination of three medications for patients with high-risk melanoma to see if it helps achieve a complete response. We also want to understand its effects on survival and safety.

High-Risk MelanomaEfficacy phase (II)No PlaceboStandard MedicinesDermatologyOncology

Buspirone for Weak Esophageal Motility

We are studying whether buspirone can improve swallowing and esophageal function in patients with poor motility. This trial compares the effects of buspirone to a placebo on symptoms and esophageal pressure measurements.

Ineffective Motility or Absent Peristalsis≤3 monthsMonitoring phase (IV)6-10 visitsStandard MedicinesPartially RemoteGastroenterology

ALS Treatment: Masitinib with Riluzole

We are studying whether adding masitinib to Riluzole helps improve outcomes for people with Amyotrophic Lateral Sclerosis. This trial will assess its safety and effectiveness compared to a placebo.

Amyotrophic Lateral Sclerosis6-12 monthsConfirmation phase (III)16-20 visitsPost-Trial Drug AccessInvestigational MedicinesInternal MedicineNeurology