Search Clinical Trials in the European Union

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1321-1340 of 1,782 trials

Carotid Artery Disease: [18F]AlF-NOTA-octreotide PET/MRI Study

We are exploring a new imaging method to better understand carotid artery disease in patients who have had a recent stroke or TIA. This study aims to see if it can help identify those at risk for future strokes.

Carotid Artery Atherosclerosis>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteCardiologyNeurology

Polypoidal Choroidal Vasculopathy: Faricimab Injections

We are studying the effects of faricimab injections on vision improvement in Caucasian patients with polypoidal choroidal vasculopathy. The trial will also assess the treatment's safety and durability.

Polypoidal Choroidal Vasculopathy>2 yearsMonitoring phase (IV)16-20 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesOphthalmology

Heart Failure: Sacubitril/Valsartan Treatment

We are studying whether the medication Sacubitril/Valsartan can improve heart function in patients with transthyretin cardiac amyloidosis and heart failure. This trial will help us understand its effects on heart pumping ability.

Transthyretin Cardiac Amyloidosis>2 yearsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesCardiologyInternal Medicine

Metastatic Tumors: Atezolizumab with SABR

We are studying the effects of a new combination treatment of atezolizumab and radiotherapy for patients with metastatic tumors. This trial aims to see if this approach can help improve survival rates and understand its safety.

Metastatic Tumors3-6 monthsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Colorectal Cancer: Temozolomide and Irinotecan Treatment

We are studying a combination of temozolomide and irinotecan for patients with specific colorectal cancer characteristics after standard chemotherapy. The goal is to see if this treatment helps eliminate remaining cancer cells and improves survival.

Stage II/III Colorectal Cancer>2 yearsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesOncology

Chronic Migraine: Xeomin Injections

We are studying Xeomin injections to see if they can help reduce the number of migraine days for people with chronic migraines. This trial compares Xeomin to a placebo to evaluate its effectiveness and safety.

Chronic Migraine6-12 monthsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessStandard MedicinesPartially RemoteNeurology

BRCA-related Metastatic Breast Cancer: Pembrolizumab and Carboplatin Study

We are testing a combination of Pembrolizumab and Carboplatin for patients with BRCA-related metastatic breast cancer. The goal is to see if this treatment improves response rates and safety compared to existing options.

Stage IV Breast Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Lung Cancer Treatment: Adagrasib with Pembrolizumab

We are studying whether adding Adagrasib to standard chemotherapy and Pembrolizumab helps patients with advanced non-small cell lung cancer with a KRAS G12C mutation. The trial will also evaluate safety and quality of life.

Metastatic Non-small Cell Lung CancerConfirmation phase (III)16-20 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementOncology

Episodic Migraine: Xeomin Injections

We are studying Xeomin injections to see if they can help reduce the number of migraine days for people with episodic migraines. This trial compares Xeomin to a placebo to evaluate its effectiveness and safety.

Episodic Migraine6-12 monthsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessStandard MedicinesPartially RemoteNeurology

Pain Management in Hernia Surgery: TAP Block vs. Local Infiltration

We are studying whether a TAP block offers better pain relief than local infiltration for patients after laparoscopic inguinal hernia repair. We also want to see if it leads to less need for pain medication.

Inguinal Hernia1-2 yearsMonitoring phase (IV)Standard MedicinesInternal MedicineOrthopedics and Traumatology

Pulmonary Hypertension: Sotatercept Study

We are investigating the safety and effects of sotatercept in individuals with pulmonary hypertension due to heart failure. This study aims to understand how well the treatment works over time.

Pulmonary Hypertension>2 yearsEfficacy phase (II)>20 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementCardiologyInternal Medicine

Triple-Negative Breast Cancer: Optimizing Pembrolizumab Use

We are studying whether observing patients after surgery is as effective as continuing pembrolizumab treatment for those who responded well to initial therapy. This trial also looks at safety, quality of life, and fertility impacts.

Early Triple-Negative Breast Cancer (TNBC)6-12 monthsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesHematologyOncology

Antibiotics in Cerebrospinal Fluid: A Study in Children

We are examining how well antibiotics work in the cerebrospinal fluid of children with an external ventricular drain. This research aims to improve treatment for infections in these patients.

Patients with External Ventricular Drain>2 yearsSafety phase (I)No PlaceboStandard MedicinesInfectious DiseasesPediatrics

HIV Treatment: Comparing DOR/3TC and DTG/3TC

We are studying whether a new two-drug regimen can maintain viral suppression in people living with HIV who are currently stable on a three-drug treatment. This trial will also assess various health outcomes and side effects over time.

HIV Disease>2 yearsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesInfectious Diseases

Alcohol-Associated Hepatitis: Alpha-1 Antitrypsin Treatment

We are studying whether intravenous Alpha-1 Antitrypsin can reduce inflammation in patients with severe alcohol-associated hepatitis. The trial also looks at its safety and effects on liver health.

Alcohol-Associated Hepatitis3-6 monthsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesHepatologyInternal Medicine

Vemurafenib for BRAF Positive Juvenile Histiocytosis

We are studying the safety and effectiveness of vemurafenib in children with BRAF mutation-resistant histiocytosis. This trial aims to find the best dosage and treatment duration for these young patients.

Histiocytic Cell Proliferation>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncologyPediatrics

Chronic Low Back Pain: Antibiotic Treatment Study

We are studying whether a three-month course of amoxicillin can help people with chronic low back pain and specific MRI changes. This trial compares the antibiotic treatment to a placebo to see if it offers any benefits.

Non-Specific Low Back Pain1-2 yearsMonitoring phase (IV)≤5 visitsPost-Trial Drug AccessStandard MedicinesInfectious DiseasesOrthopedics and Traumatology

Oxybutynin for Boys with Posterior Urethral Valves

We are studying whether early treatment with oxybutynin improves bladder function in boys after surgery for posterior urethral valves. The trial also looks at the safety of the medication and its effects on urinary tract infections.

Urethral Posterior Valve>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesPediatricsUrology

Acute Kidney Injury: Angiotensin Receptor Blocker Study

We are studying whether an angiotensin receptor blocker can improve heart and kidney health in patients recovering from acute kidney injury after ICU discharge. This trial will help us understand its effects on overall health and safety.

Acute Kidney Injury>2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesCardiologyInternal MedicineNephrology

Chickenpox Vaccine Safety Study for Young Children

We are evaluating the safety of a new chickenpox vaccine for healthy children aged 12 to 15 months. This study compares it with an existing vaccine when given with other routine immunizations.

Chickenpox6-12 monthsConfirmation phase (III)No PlaceboStandard MedicinesCost ReimbursementPartially RemoteInfectious DiseasesPediatrics