Search Clinical Trials in the European Union

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121-140 of 1,782 trials

Zilucoplan for Children with Generalized Myasthenia Gravis

We are studying the long-term safety of zilucoplan in children with generalized myasthenia gravis who participated in an earlier trial. This research aims to understand how well the treatment works and its effects over time.

Myasthenia GravisConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteNeurologyPediatrics

Myasthenia Gravis: Rozanolixizumab for Kids

We are studying if rozanolixizumab is safe and effective for children with moderate to severe myasthenia gravis. This trial will help us understand how the medication works in young patients.

Myasthenia Gravis3-6 monthsEfficacy phase (II)Confirmation phase (III)No PlaceboStandard MedicinesNeurologyPediatrics

Osteoporosis: Dasatinib and Quercetin Study

We are investigating whether a combination of dasatinib and quercetin can help improve bone health in patients with low bone mass. This study aims to see if it reduces bone loss more effectively than current treatments.

OsteoporosisOsteopenia3-6 monthsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesCost ReimbursementEndocrinologyOrthopedics and Traumatology

Semaglutide for Glucose Intolerance in Women with Prior Gestational Diabetes

We are studying whether semaglutide can help women with a history of gestational diabetes manage glucose intolerance and reduce the risk of developing type 2 diabetes.

Prediabetes>2 yearsConfirmation phase (III)Monitoring phase (IV)6-10 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementPartially RemoteEndocrinologyGynecology and Obstetrics

Small Cell Lung Cancer: Niraparib with Immunotherapy

We are studying the effects of adding niraparib to immunotherapy for patients with SLFN11-positive small cell lung cancer. This research aims to see if it improves treatment after initial therapy.

Extensive Stage Small Cell Lung Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesPartially RemoteOncologyPulmonology

Semaglutide for Reducing GI Issues in Chemotherapy Patients

We are studying whether semaglutide can help lessen gastrointestinal problems in patients undergoing high-dose chemotherapy and stem cell transplantation. The trial also looks at its safety and effects on gut health.

Mucositis and Systemic Inflammation3-6 monthsEfficacy phase (II)Standard MedicinesCost ReimbursementGastroenterologyOncology

Atrial Fibrillation: WOEST-3 Study

We are exploring a new antithrombotic strategy for patients with atrial fibrillation undergoing heart procedures. The goal is to see if this approach reduces bleeding and heart-related risks compared to standard treatment.

Atrial FibrillationAcute Coronary SyndromeChronic Coronary Syndrome1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCost ReimbursementCardiologyInternal Medicine

Hydroxychloroquine for Extra-pulmonary Sarcoidosis

We are studying whether hydroxychloroquine can reduce the need for steroids in patients with extra-pulmonary sarcoidosis. This trial will also look at its effects on quality of life and potential side effects.

Sarcoidosis>2 yearsConfirmation phase (III)Standard MedicinesInternal MedicineRheumatology

Kidney Disease: Iptacopan (LNP023) Study

We are testing a new medication for people with idiopathic immune complex mediated membranoproliferative glomerulonephritis to see if it reduces protein in urine and improves kidney function. The study also evaluates how well patients feel while using this treatment.

Idiopathic Immune Complex Mediated Membranoproliferative GlomerulonephritisConfirmation phase (III)6-10 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementPartially RemoteInternal MedicineNephrology

Semaglutide for Weight Loss in Low Responders After Bariatric Surgery

We are studying whether Semaglutide 2.4 mg can help individuals who haven't lost enough weight after bariatric surgery. This trial compares its effects with a placebo to see how it impacts weight loss and overall health.

Obesity1-2 yearsMonitoring phase (IV)>20 visitsStandard MedicinesDiabetologyEndocrinologyInternal Medicine

Atorvastatin for Preventing Episodic Migraines

We are studying whether atorvastatin can help reduce the frequency of episodic migraines in participants. This trial will also look at how well different doses work and any side effects that may occur.

Migraine3-6 monthsEfficacy phase (II)≤5 visitsStandard MedicinesNeurology

Chronic Migraine: Atorvastatin Study

We are investigating whether atorvastatin can help prevent chronic migraines in adults. The study will also assess how many people respond to the treatment and any potential side effects.

Chronic MigraineEfficacy phase (II)Standard MedicinesInternal MedicineNeurology

Bladder Cancer Treatment: Chemoablation vs. Standard Care

We are studying whether a new chemoablation method is more effective than standard bladder surgery and chemotherapy for patients with recurrent non-muscle invasive bladder cancer. This may help reduce recurrence rates and improve long-term outcomes.

Recurrent Non-Muscle Invasive Bladder Cancer>2 yearsMonitoring phase (IV)11-15 visitsNo PlaceboStandard MedicinesCost ReimbursementOncologyUrology

HPV Vaccine Effectiveness Study for Young Men

We are studying how well the bivalent HPV vaccine protects men aged 19-26 who have sex with men from anal HPV-16/18 infections. This research aims to understand vaccination impact and related factors.

HPV InfectionHealthy Participants6-12 monthsMonitoring phase (IV)No PlaceboStandard MedicinesInfectious Diseases

Hodgkin Lymphoma: Tislelizumab with Gemcitabine and Cisplatin

We are studying a combination of tislelizumab, gemcitabine, and cisplatin for patients with relapsed or refractory Hodgkin lymphoma. The goal is to see if this treatment improves survival and response rates.

Hodgkin Lymphoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesHematologyOncology

Ventilator-Acquired Pneumonia: Interferon Gamma Treatment

We are studying whether recombinant human interferon gamma can help ICU patients with ventilator-acquired pneumonia breathe easier and recover faster. This trial looks at its effects alongside standard antibiotic treatment.

Ventilator-Associated PneumoniaConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesInternal MedicinePulmonology

Guselkumab for Children with Ulcerative Colitis

We are studying whether guselkumab can effectively treat moderately to severely active ulcerative colitis in children. This trial will help us understand its safety and how well it works over time.

Ulcerative Colitis1-2 yearsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementPartially RemoteGastroenterologyPediatrics

Heart Failure: Comparing Spironolactone and Eplerenone

We are studying whether spironolactone or eplerenone is more effective in reducing the risk of death for patients with heart failure. This trial is for those receiving treatment in a heart failure clinic.

Heart Failure>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyInternal Medicine

Prostate Cancer: Metastasis-Directed Therapy Study

We are investigating if a new treatment can improve survival for men with castration-refractory prostate cancer and a few progressive lesions. This study compares the new approach to standard care to see which is more effective.

Oligoprogressive Metastatic Castration-Refractory Prostate Cancer>2 yearsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesOncologyUrology

Infliximab for Non-Crohn Anal Fistulas

We are studying whether Infliximab can improve healing in patients with complex anal fistulas after surgery. This trial aims to find out if this treatment helps reduce complications and improve recovery.

Anal Fistula>2 yearsEfficacy phase (II)Standard MedicinesGastroenterologyInternal Medicine