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1761-1780 of 1,782 trials

Multiple Sclerosis: Subcutaneous vs. Intravenous Ublituximab

We are studying how a new subcutaneous injection of ublituximab compares to the intravenous version for people with relapsing multiple sclerosis. The goal is to evaluate its safety and effectiveness in managing the condition.

Relapsing Multiple SclerosisConfirmation phase (III)No PlaceboStandard MedicinesCost ReimbursementNeurology

Mantle Cell Lymphoma: Acalabrutinib with R-CHOP

We are studying the combination of acalabrutinib and R-CHOP for patients with previously untreated mantle cell lymphoma. The goal is to see if this combination improves treatment response and is safe.

Mantle Cell Lymphoma>2 yearsEfficacy phase (II)16-20 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesHematologyOncology

Chronic Subdural Hematoma: Timing of Anticoagulation

We are studying whether starting blood-thinning medication early or later helps patients with atrial fibrillation recover better after surgery for chronic subdural hematoma. This research looks at potential risks and overall health outcomes.

Chronic Subdural HematomaAtrial Fibrillation3-6 monthsEfficacy phase (II)Confirmation phase (III)No PlaceboStandard MedicinesPartially RemoteCardiologyInternal MedicineNeurology

Immunotherapy for Metastatic Colorectal and Prostate Cancer

We are studying a new treatment using patients' own immune cells to see if it is safe and tolerable for those with advanced colorectal or prostate cancer. The trial will help us understand how well this therapy works in these patients.

Locally Advanced or Metastatic Prostate CancerMetastatic Colorectal Cancer>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesPartially RemoteGastroenterologyOncologyUrology

IVF/ICSI: Low Dose hCG Priming for Women with Diminished Ovarian Reserve

We are investigating whether low dose hCG priming can help women with diminished ovarian reserve retrieve more eggs during IVF/ICSI. This study aims to confirm earlier findings that suggest a significant increase in egg retrieval.

Infertility Due to Diminished Ovarian Reserve>2 yearsConfirmation phase (III)Standard MedicinesGynecology and Obstetrics

Birth Control Study: Levonorgestrel Tablet

We are investigating whether the Levonorgestrel tablet can still prevent ovulation despite planned delays in taking the pill. This study is for individuals interested in understanding the reliability of this contraceptive method.

Ovulation Inhibition6-12 monthsEfficacy phase (II)No PlaceboStandard MedicinesGynecology and Obstetrics

Atrial Fibrillation: Early Rhythm-Control Therapy for Stroke Prevention

We are studying if starting rhythm-control therapy early helps patients with atrial fibrillation after a stroke avoid further heart problems. This trial also examines the impact on quality of life and treatment costs.

Acute Ischemic Stroke and Atrial Fibrillation>2 yearsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesPartially RemoteCardiologyInternal Medicine

Chikungunya Vaccine: Effectiveness and Safety Study

We are evaluating how well the chikungunya vaccine works in preventing severe disease and hospitalizations in at-risk populations. This study aims to understand the vaccine's real-life impact on health outcomes.

Chikungunya1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInfectious Diseases

Durvalumab for Limited Stage Small Cell Lung Cancer

We are studying the safety and effectiveness of durvalumab for patients with limited stage small cell lung cancer who have not progressed after chemoradiation therapy. This trial also looks at how the treatment affects quality of life and disease symptoms.

Small Cell Lung Cancer>2 yearsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesOncology

Cerebrolysin for Recovery After Ischemic Stroke

We are studying whether Cerebrolysin can improve upper limb function and overall recovery in patients after an ischemic stroke. Participants will be compared to those receiving a placebo to assess various health outcomes.

Ischaemic Stroke3-6 monthsConfirmation phase (III)≤5 visitsStandard MedicinesNeurology

Colonoscopy Prep: Mannitol vs. Plenvu®

We are studying whether mannitol is as effective and acceptable as Plenvu® for bowel preparation before a colonoscopy. This trial aims to ensure patient comfort and safety during the procedure.

Colonoscopy3-6 monthsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteGastroenterology

Covert Brain Infarction: Antiplatelet and Lipid-Lowering Treatments

We are studying whether adding antiplatelet and cholesterol-lowering medications can help patients with covert brain infarctions reduce serious health risks. This trial will also assess the impact on cognitive health and overall mortality.

Covert Brain Infarct>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesPartially RemoteCardiologyNeurology

Gastric Cancer: Intraperitoneal Irinotecan Study

We are exploring a new treatment combining intraperitoneal irinotecan with standard therapy for patients with gastric cancer that has spread to the abdomen. This study aims to evaluate its safety, effectiveness, and impact on quality of life.

Gastric Peritoneal Metastases>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesCost ReimbursementOncology

Migraine Study: Effects of Cilostazol

We are investigating how cilostazol affects migraine headaches in men and women without aura. The study looks at potential differences in response based on sex.

Migraine6-12 monthsSafety phase (I)Efficacy phase (II)≤5 visitsStandard MedicinesCost ReimbursementPartially RemoteNeurology

Cangrelor for Acute Ischemic Stroke Treatment

We are studying the safety and effectiveness of an intravenous medication called Cangrelor for patients with acute ischemic stroke and significant carotid artery blockage. This trial aims to see if it helps improve blood flow during emergency stenting procedures.

Ischemic Stroke with Large Artery Occlusion>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteCardiologyNeurology

Type 2 Diabetes: SGLT-2 Inhibitors and Heart Health

We are studying how SGLT-2 inhibitors may improve heart function and nerve health in people with type 2 diabetes. This research aims to understand the connection between these medications and heart regulation.

Type 2 DiabetesMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesCardiologyEndocrinologyNeurology

RSV Immunization Study: Nirsevimab for Infants

We are studying how the nirsevimab immunization affects infants' immune responses to RSV infections. This research aims to understand the role of age, weight, and maternal antibodies in developing immunity.

Healthy Infants1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesInfectious DiseasesPulmonology

Bile Acid Diarrhea: Atorvastatin Treatment Study

We are investigating whether atorvastatin can help reduce bile acid production and improve symptoms in patients with moderate to severe bile acid diarrhea. The study will also look at various health markers and safety.

Bile Acid Diarrhoea3-6 monthsConfirmation phase (III)Monitoring phase (IV)6-10 visitsStandard MedicinesCost ReimbursementGastroenterology

Open-Heart Surgery: Parasternal Block for Pain Relief

We are studying whether a special nerve block helps reduce pain and opioid use in patients recovering from open-heart surgery. This trial aims to improve recovery experiences for these patients.

Postoperative Pain Management>2 yearsConfirmation phase (III)Monitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesPartially RemoteCardiologyInternal MedicineOtolaryngology

Cabergoline for Episodic Migraine Relief

We are studying whether cabergoline can help reduce the frequency and severity of migraines in people with episodic migraine. Participants will receive either cabergoline or a placebo to compare effects.

Episodic Migraine6-12 monthsConfirmation phase (III)≤5 visitsPost-Trial Drug AccessStandard MedicinesPartially RemoteNeurology