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481-500 of 525 trials

Non-Small Cell Lung Cancer: Cemiplimab and TEDOPI® Study

We are testing a new combination therapy for patients with non-small cell lung cancer who have not progressed after initial treatment. The goal is to see if this therapy helps clear cancer markers and improves survival compared to standard treatment.

Non-Small Cell Lung Cancer>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesPartially RemoteOncology

Meningococcal Vaccine Study for Ages 10-20

We are testing a booster dose of the rMenB+OMV NZ vaccine in healthy participants aged 10 to 20 who were vaccinated in early childhood. The study aims to see how well it enhances their immune response and evaluates its safety.

Invasive Meningococcal DiseaseConfirmation phase (III)≤5 visitsNo PlaceboInvestigational MedicinesInfectious DiseasesPediatrics

Melanoma Treatment: Comparing Immune Therapies

We are studying two different immune therapy treatments for patients with resectable stage III melanoma. Our goal is to see which treatment may help improve survival without disease progression.

Stage III Malignant MelanomaConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesDermatologyOncology

Chronic Rhinosinusitis: Stopping Treatment Study

We are investigating if patients with severe nasal polyps can safely stop treatment after a year without symptoms. We also want to see if one medication works better than the other for achieving this.

Chronic Rhinosinusitis with Nasal Polyps1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesAllergologyOtolaryngology

Oxytocin Infusion: Effects on Sensory Nerves

We are studying how intravenous oxytocin affects sensory nerve responses and cognitive performance in healthy volunteers. This research may help us understand its role in pain perception and inflammation.

Healthy Participants>2 yearsSafety phase (I)≤5 visitsStandard MedicinesNeurologyPsychiatry

High-Dose Influenza Vaccine for Adults 60 and Older

We are studying a new high-dose flu vaccine to see if it provides better immune protection than a standard vaccine for adults aged 60 and above. The trial will also assess the safety of this new vaccine.

Influenza Immunization1-2 yearsConfirmation phase (III)≤5 visitsNo PlaceboInvestigational MedicinesCost ReimbursementGastroenterologyInfectious Diseases

Chronic Rhinosinusitis with Nasal Polyps: Tapering Biologics

We are studying whether patients with stable chronic rhinosinusitis can safely reduce their biologic medication dosage after a year. This trial compares the effects of Mepolizumab and Dupilumab on disease control.

Chronic Rhinosinusitis with Nasal Polyps1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesAllergologyOtolaryngology

Anal High-Grade Lesions: Sinecatechins Ointment

We are studying whether adding a topical ointment to standard treatment helps patients with high-grade anal lesions achieve better results. The goal is to see if it reduces lesions and prevents recurrence.

Anal High-Grade Squamous Intraepithelial Lesions (HSIL)1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboInvestigational MedicinesPartially RemoteGastroenterologyOncology

Chronic Heart Failure: Vitamin D and Oral Iron Study

We are studying whether vitamin D combined with oral iron can improve symptoms in patients with chronic heart failure and iron deficiency. This trial compares it to standard intravenous iron treatment to see which is more effective.

Chronic Heart FailureIron Deficiency3-6 monthsMonitoring phase (IV)≤5 visitsNo PlaceboInvestigational MedicinesCardiologyInternal Medicine

Type 1 Diabetes: Once-Weekly Insulin Icodec vs. Daily Insulin Glargine

We are studying whether a new once-weekly insulin can help adults with type 1 diabetes manage their blood sugar levels as well as the standard daily insulin. This trial will also look at safety and patient experiences.

Type 1 Diabetes6-12 monthsConfirmation phase (III)≤5 visitsNo PlaceboInvestigational MedicinesDiabetologyEndocrinology

Botox for Hidradenitis Suppurativa Treatment

We are studying whether Botox can help reduce symptoms in patients with Hidradenitis Suppurativa. This trial will assess changes in skin condition and patient satisfaction over several months.

Hidradenitis SuppurativaMonitoring phase (IV)≤5 visitsPost-Trial Drug AccessStandard MedicinesAllergologyDermatology

Breast Cancer Prevention: Exemestane vs. Tamoxifen

We are comparing two low-dose medications for post-menopausal women at high risk for breast cancer to see which one may improve quality of life and hormonal balance. This study aims to understand their effects over 12 months.

Breast Cancer>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesGynecology and ObstetricsOncology

Breast Cancer Treatment: Elacestrant Study

We are studying whether Elacestrant alone is as effective as Elacestrant with ovarian function suppression in premenopausal women with early-stage ER+/HER2- breast cancer. The trial also looks at the safety of these treatment options.

Breast Cancer1-2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesGynecology and ObstetricsOncology

Lung Cancer: Nivolumab with Ipilimumab and Chemotherapy

We are studying a new way to administer nivolumab alongside ipilimumab and chemotherapy for patients with untreated metastatic or recurrent lung cancer. The trial aims to understand how the body reacts to this combination and its safety.

Non-small cell lung cancer6-12 monthsEfficacy phase (II)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesOncology

Irritable Bowel Syndrome: Saccharomyces boulardii CNCM I-745

We are studying whether a probiotic can help adults with non-constipated IBS feel better and improve their quality of life compared to a placebo.

Non-constipated Irritable Bowel Syndrome3-6 monthsConfirmation phase (III)≤5 visitsStandard MedicinesCost ReimbursementPartially RemoteGastroenterology

Breast Cancer: Typology-based Coaching with Ribociclib

We are studying whether personalized coaching and education can help patients with HR+ HER2- early breast cancer stay on their ribociclib treatment. This may improve their treatment experience and overall health outcomes.

Hormone Receptor Positive Breast CancerBreast Cancer>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteInternal MedicineOncology

Scabies Treatment Comparison: Permethrin vs. Ivermectin

We are comparing the effectiveness of topical permethrin, oral ivermectin, and their combination for treating scabies. The goal is to find out which treatment works best and is safest for patients.

Scabies≤3 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesDermatologyInfectious Diseases

Influenza Vaccine Study: OVX836

We are testing the OVX836 influenza vaccine in healthy adults to see if it can prevent influenza compared to a placebo. This study will also look at the vaccine's safety and how well it triggers an immune response.

Influenza6-12 monthsEfficacy phase (II)≤5 visitsInvestigational MedicinesPartially RemoteInfectious Diseases

Onychomycosis: DexULac® Treatment Study

We are studying how well DexULac® works for treating nail fungal infections and its impact on patients' quality of life. This trial will help us understand the effectiveness and safety of this treatment over time.

Nail Fungus (Onychomycosis)1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesDermatologyInfectious Diseases

Spinocerebellar Ataxia SCA27B: Fampridine Study

We are investigating whether fampridine can help improve movement and daily activities in patients with spinocerebellar ataxia SCA27B. This study will also assess its effects on quality of life and overall health.

Spinocerebellar Ataxia1-2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesInternal MedicineNeurology