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1-20 of 525 trials

Urothelial Cancer: Disitamab Vedotin with Pembrolizumab

We are studying the effects of disitamab vedotin alone or with pembrolizumab in patients with HER2-positive urothelial cancer. This trial aims to see if these treatments can improve outcomes for those with advanced disease.

Bladder CancerEfficacy phase (II)≤5 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementOncology

Nalmefene for Reducing Cravings in Behavioral Addictions

We are studying whether nalmefene can help reduce craving intensity in people with behavioral addictions, such as gambling and food addiction, when added to their usual treatment.

Behavioural AddictionConfirmation phase (III)≤5 visitsStandard MedicinesCost Reimbursement

Cholangiocarcinoma: Comparing RFA and PDT Treatments

We are studying whether radiofrequency ablation or photodynamic therapy helps patients with cholangiocarcinoma live longer. We’ll also look at how these treatments affect quality of life and any potential side effects.

Hilar Cholangiocarcinoma>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteGastroenterologyOncology

Hydrochlorothiazide for Polycystic Kidney Disease Patients

We are studying whether adding hydrochlorothiazide to tolvaptan can help slow kidney function decline in people with polycystic kidney disease. This trial also looks at how this combination affects quality of life and treatment tolerability.

Autosomal Dominant Polycystic Kidney Disease>2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesPartially RemoteInternal MedicineNephrology

Rheumatoid Arthritis: Abatacept vs. TNF Inhibitors

We are comparing a new treatment strategy using abatacept to the standard TNF inhibitors for patients with rheumatoid arthritis. The goal is to see which approach helps more patients achieve remission.

Rheumatoid Arthritis6-12 monthsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesInternal MedicineRheumatology

Postoperative Pain Management: Genetic Testing for Tramadol

We are studying whether genetic testing can help tailor tramadol treatment for better pain relief and fewer side effects after surgery. This trial also compares tramadol with another pain medication to find the most effective option.

PharmacogeneticsTherapeutic Techniques for Acute Postoperative PainMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesInternal MedicineNeurologyPsychiatry

Febrile Neutropenia: SAFE Study on Short Antibiotic Treatment

We are studying whether stopping antibiotics after 3 days is as safe as continuing them longer for patients with febrile neutropenia. This research aims to find a potentially safer treatment approach for hematology patients.

Febrile Neutropenia>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesHematologyInfectious Diseases

Preventing Dementia: Metformin and Lifestyle Changes

We are studying whether a combination of metformin and a structured lifestyle program can help older adults at risk for dementia improve their cognitive abilities and overall health compared to a self-guided approach.

Cognitive Impairment Prevention>2 yearsEfficacy phase (II)≤5 visitsStandard MedicinesPartially RemoteGastroenterologyNeurology

HER2 Status in Solid Tumors: [68Ga]Ga-ABY-025 PET Study

We are investigating a new PET imaging method to measure HER2 status in patients with low HER2 breast cancer. This study aims to see if it can help better identify tumor characteristics and improve treatment planning.

Breast CancerGastro-esophageal Cancer>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesGastroenterologyOncology

Ikervis for Atopic Keratoconjunctivitis

We are studying whether Ikervis, applied four times a day, can effectively treat atopic keratoconjunctivitis. This trial aims to see how well it works compared to a placebo.

Atopic Keratoconjunctivitis3-6 monthsEfficacy phase (II)≤5 visitsInvestigational MedicinesCost ReimbursementOphthalmology

Atrial Fibrillation: Colchicine Study

We are investigating whether colchicine can help prevent the return of atrial fibrillation in patients scheduled for heart rhythm treatment. We will also look at its effects on heart health and quality of life.

Atrial Fibrillation and Atrial Flutter>2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesCardiology

Aspirin for Preventing Preeclampsia in First-Time Pregnant Women

We are studying whether daily aspirin can help prevent preeclampsia and improve pregnancy outcomes in women who are pregnant for the first time after assisted reproductive technology. This trial compares aspirin to a placebo to see which is more effective.

Preeclampsia>2 yearsConfirmation phase (III)Monitoring phase (IV)≤5 visitsStandard MedicinesPartially RemoteGynecology and Obstetrics

Preventing Second Cancers: Dostarlimab Study

We are studying whether dostarlimab can help prevent second primary cancers in patients who have been cured of their first cancer. This trial will also look at the safety of the treatment.

Cancer Survivor at Risk for Second Cancer≤3 monthsEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesOncology

Rituximab for Progressive Interstitial Lung Disease

We are studying whether rituximab can improve lung function in patients with progressive interstitial lung disease. This trial compares its effects to a placebo to assess safety and quality of life.

Interstitial Lung Disease>2 yearsEfficacy phase (II)Confirmation phase (III)≤5 visitsStandard MedicinesInternal MedicinePulmonology

Severe Pneumonia: Testing Trimodulin

We are studying whether trimodulin can improve survival in hospitalized adults with severe pneumonia compared to a placebo. The trial also looks at the safety and effects of the treatment.

Community Acquired PneumoniaConfirmation phase (III)≤5 visitsInvestigational MedicinesCost ReimbursementPartially RemoteInternal MedicinePulmonology

Atrial Fibrillation: Semaglutide for Weight Control

We are studying whether a weekly injection of semaglutide helps people with obesity and atrial fibrillation achieve a normal heart rhythm. The trial also looks at how weight loss affects symptoms and quality of life.

ObesityAtrial Fibrillation1-2 yearsMonitoring phase (IV)≤5 visitsInvestigational MedicinesCardiologyEndocrinologyInternal Medicine

COVID-19 Treatment: Antiviral Therapy for Immunocompromised Patients

We are studying a combination of antiviral medications to see if it helps immunocompromised patients recover from COVID-19 more effectively. The goal is to improve viral clearance and reduce symptoms compared to standard treatments.

Covid-193-6 monthsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteInfectious DiseasesInternal Medicine

Cognitive Deficits in Multiple Sclerosis: MODAFIMS Study

We are studying the effects of modafinil on cognitive deficits in people with Multiple Sclerosis. The trial aims to identify brain features that may predict treatment response and assess changes in cognitive function and quality of life.

Multiple Sclerosis6-12 monthsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesNeurology

Skin Candidiasis: Mecloderm® Ointment Study

We are comparing a new ointment with clotrimazole and betamethasone to an existing treatment and a placebo for patients with moderate to severe skin infections caused by yeast. The study aims to assess how well these treatments work and their safety.

Skin and Nail Candidiasis≤3 monthsConfirmation phase (III)≤5 visitsStandard MedicinesDermatologyInfectious Diseases

Dexamethasone for Moderate to Severe Depression

We are studying whether adding dexamethasone to standard depression treatment can improve symptoms for those with moderate to severe depression. This trial aims to assess its safety and effectiveness.

Depression6-12 monthsConfirmation phase (III)≤5 visitsInvestigational MedicinesCost ReimbursementPartially RemotePsychiatry