Search Clinical Trials in the European Union

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201-220 of 1,738 trials

Knee Cartilage Defects: Stem Cell Treatment Study

We are testing whether a combination of stem cells and a 3D scaffold improves healing in knee cartilage defects compared to standard treatment. This study also looks at the safety of using these stem cells.

Knee Cartilage Defect>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementOrthopedics and TraumatologyRheumatology

Fish Oil for Recovery in High-Risk Heart Surgery Patients

We are studying whether an intravenous fish oil treatment can prevent atrial fibrillation and improve recovery in patients undergoing high-risk cardiac surgery. This trial compares the fish oil treatment to a placebo.

Critical Illness3-6 monthsEfficacy phase (II)Investigational MedicinesCardiologyInternal Medicine

Pembrolizumab for Progressive Multifocal Leukoencephalopathy in Immunocompromised Patients

We are studying whether Pembrolizumab can help reduce the JCV viral load in the cerebrospinal fluid of immunocompromised patients with PML. This trial aims to understand its effects on neurological health and overall survival.

Progressive Multifocal Leukoencephalopathy (PML)6-12 monthsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesInfectious DiseasesNeurology

Lung Cancer: Adagrasib Dosing Study

We are comparing two dosing schedules of adagrasib for patients with non-small cell lung cancer and a KRAS G12C mutation who have had previous treatments. The goal is to find out which regimen works better and is safer.

Non-small cell lung cancerEfficacy phase (II)No PlaceboStandard MedicinesCost ReimbursementOncology

Rare Ovarian Cancer: Abemaciclib and Letrozole Study

We are investigating the effects of a new treatment combining abemaciclib and letrozole for women with estrogen receptor positive rare ovarian cancer. The study aims to understand how well this treatment works and its impact on quality of life.

Adult-type Granulosa Cell TumorLow-Grade Serous Ovarian Cancer>2 yearsEfficacy phase (II)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteOncology

Triple-Negative Breast Cancer: New Treatment Strategies

We are exploring new therapies for patients with early relapsed metastatic triple-negative breast cancer. The study aims to understand their safety and effectiveness compared to existing options.

Hormone-Receptor Negative and HER2-Negative Breast CancerSafety phase (I)Efficacy phase (II)Oncology

Liver Surgery: Octreotide Study

We are investigating whether octreotide can reduce blood loss and improve stability during laparoscopic liver surgery. This study will help us understand its effects compared to a placebo.

Laparoscopic Hepatectomy Surgery>2 yearsEfficacy phase (II)Standard MedicinesHepatologyInternal MedicineOtolaryngology

Metastatic Breast Cancer: Treatment Combinations Study

We are evaluating the effectiveness and safety of various treatment combinations for patients with metastatic breast cancer. This study aims to find better options for managing the disease.

Metastatic Breast Cancer>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesOncology

Atopic Dermatitis in Children: Tralokinumab Treatment

We are studying whether a new treatment with tralokinumab and topical steroids helps children aged 2 to under 12 and infants aged 6 months to under 2 manage moderate-to-severe atopic dermatitis better than a placebo. The trial also looks at how this treatment affects daily life and skin health.

Atopic Dermatitis1-2 yearsEfficacy phase (II)Confirmation phase (III)Post-Trial Drug AccessStandard MedicinesCost ReimbursementPartially RemoteAllergologyDermatology

Gastroesophageal and Pancreatic Cancer: New Imaging Technique

We are testing a new PET/CT imaging method to see if it improves cancer diagnosis and staging for patients with gastroesophageal and pancreatic cancer. This study aims to enhance comfort and effectiveness compared to standard imaging.

Pancreatic and Gastroesophageal CancerEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesOncologyOtolaryngology

Advanced Solid Tumors: BMS-986340 Treatment Study

We are testing a new treatment called BMS-986340, both alone and with other medications, for people with advanced solid tumors. The goal is to assess its safety and how well it may work against cancer.

Advanced Cancer>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesOncology

Advanced Cholangiocarcinoma: Futibatinib Study

We are studying the effects of futibatinib in patients with advanced cholangiocarcinoma with FGFR2 fusions or rearrangements. The goal is to see if it helps improve their condition and to understand its safety.

Cholangiocarcinoma6-12 monthsEfficacy phase (II)No PlaceboStandard MedicinesCost ReimbursementPartially RemoteOncology

Progressive Pulmonary Fibrosis: FAPI-PET Imaging Study

We are exploring if a special imaging method can help identify the type of lung condition in patients with progressive pulmonary fibrosis. This may improve how we understand and treat their disease.

Progressive Pulmonary Fibrosis3-6 monthsSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesPulmonology

Preventing Hearing Loss: ACOU085 for Testicular Cancer Patients

We are studying whether ACOU085 can help prevent hearing loss in testicular cancer patients undergoing treatment with cisplatin. The trial will assess the safety and effectiveness of this treatment through ear injections.

Sensorineural Hearing Loss3-6 monthsEfficacy phase (II)≤5 visitsInvestigational MedicinesOncologyOtolaryngology

Severe Epilepsy: Cannabidiol Oral Solution

We are studying whether Cannabidiol can help reduce seizures in children and young adults with rare disease-related severe epilepsy. The trial also looks at safety and how it interacts with current medications.

Epilepsy3-6 monthsEfficacy phase (II)No PlaceboStandard MedicinesNeurologyPediatrics

Relatlimab and Nivolumab for Young Lymphoma Patients

We are studying a combination of two medications for children and young adults with recurrent or hard-to-treat Hodgkin and Non-Hodgkin lymphoma. The goal is to understand their safety and how well they may work.

Classical Hodgkin Lymphoma and Non-Hodgkin Lymphoma3-6 monthsSafety phase (I)Efficacy phase (II)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteOncologyPediatrics

Heart Failure and Obesity: Weight Loss with Semaglutide

We are investigating whether weight loss using semaglutide is more effective than a calorie-restricted diet in improving physical performance for patients with heart failure and obesity. The study also looks at quality of life and heart health impacts from both weight loss methods.

Heart Failure with Reduced Ejection FractionObesity1-2 yearsEfficacy phase (II)11-15 visitsNo PlaceboInvestigational MedicinesPartially RemoteCardiologyDiabetologyEndocrinology

Advanced Non-Small Cell Lung Cancer: BAY2927088 Study

We are testing a new treatment for patients with advanced NSCLC who have mutations in the EGFR and/or HER2 genes. This study aims to explore its effects on cancer progression.

Advanced Non-Small Cell Lung Cancer>2 yearsSafety phase (I)Efficacy phase (II)OncologyPulmonology

Esophageal Cancer Detection: Fluorescent Tracers Study

We are testing a new method using oral fluorescent tracers to help detect early esophageal adenocarcinomas in patients with Barrett's esophagus. This study aims to see if this approach improves detection compared to standard endoscopy.

Barrett's EsophagusEfficacy phase (II)No PlaceboStandard MedicinesGastroenterologyOncology

Mild Male Factor Infertility: PKB171 Gel Study

We are testing a new intravaginal gel to see if it helps couples with mild male factor infertility achieve pregnancy. The study compares the gel's effects to a placebo over three treatment cycles.

Male Infertility6-12 monthsEfficacy phase (II)Confirmation phase (III)6-10 visitsInvestigational MedicinesPartially RemoteGynecology and ObstetricsUrology