Search Clinical Trials in the European Union

>2 years
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241-260 of 1,743 trials

Polycystic Ovary Syndrome: Letrozole vs. Gonadotropins for Insemination

We are studying whether letrozole can be a better option than gonadotropins for achieving pregnancy in women with polycystic ovary syndrome. The trial will also examine miscarriage rates and treatment responses.

Insemination in Patients with Polycystic Ovary Syndrome>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesEndocrinologyGynecology and Obstetrics

Non-Squamous Lung Cancer: Pembrolizumab Dosing Study

We are comparing the usual dose of Pembrolizumab with a lower dose for patients with non-squamous lung cancer. The goal is to see if the lower dose is as effective in maintaining treatment benefits.

Metastatic Non-Squamous Lung Cancer>2 yearsConfirmation phase (III)OncologyPulmonology

Knee Cartilage Defects: Stem Cell Treatment Study

We are testing whether a combination of stem cells and a 3D scaffold improves healing in knee cartilage defects compared to standard treatment. This study also looks at the safety of using these stem cells.

Knee Cartilage Defect>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementOrthopedics and TraumatologyRheumatology

Prostate Cancer: VIR-5500 Treatment

We are studying the safety and early effects of VIR-5500 in men with prostate cancer. This trial aims to understand how well the treatment works and how it is processed in the body.

Hormone-Refractory Prostate Cancer>2 yearsSafety phase (I)Oncology

Preventing Postoperative Pain in Children: Locoregional Analgesia Study

We are studying whether locoregional analgesia can help reduce long-term pain after orthopedic surgery in children. The trial compares pain levels and recovery outcomes between different pain management methods.

Postoperative Pain>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesOrthopedics and TraumatologyOtolaryngology

Metastatic Non-Small Cell Lung Cancer: Pembrolizumab with Sacituzumab Govitecan

We are studying whether combining pembrolizumab with sacituzumab govitecan improves survival and quality of life for patients with metastatic non-small cell lung cancer. This trial compares the combination treatment to pembrolizumab alone.

Metastatic Non-small Cell Lung Cancer>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesCost ReimbursementOncology

Rare Ovarian Cancer: Abemaciclib and Letrozole Study

We are investigating the effects of a new treatment combining abemaciclib and letrozole for women with estrogen receptor positive rare ovarian cancer. The study aims to understand how well this treatment works and its impact on quality of life.

Adult-type Granulosa Cell TumorLow-Grade Serous Ovarian Cancer>2 yearsEfficacy phase (II)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteOncology

MK-2870 vs Chemotherapy for Advanced Lung Cancer

We are studying a new treatment, MK-2870, for patients with advanced nonsquamous non-small cell lung cancer who have specific genetic mutations. The goal is to see if it works better than standard chemotherapy options.

Non-small Cell Lung Cancer>2 yearsConfirmation phase (III)Investigational MedicinesOncology

B-Cell Malignancies: Oral ABBV-101 Study

We are evaluating a new oral medication for adults with B-cell malignancies to see how it affects disease activity and its safety. This study will help us understand how the medication works in the body.

Non-Hodgkin's B-Cell Lymphoma>2 yearsSafety phase (I)HematologyOncology

Liver Surgery: Octreotide Study

We are investigating whether octreotide can reduce blood loss and improve stability during laparoscopic liver surgery. This study will help us understand its effects compared to a placebo.

Laparoscopic Hepatectomy Surgery>2 yearsEfficacy phase (II)Standard MedicinesHepatologyInternal MedicineOtolaryngology

Metastatic Breast Cancer: Treatment Combinations Study

We are evaluating the effectiveness and safety of various treatment combinations for patients with metastatic breast cancer. This study aims to find better options for managing the disease.

Metastatic Breast Cancer>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesOncology

Community-Acquired Pneumonia: Amoxicillin vs. Amoxicillin/Clavulanate

We are studying whether amoxicillin alone is as effective as amoxicillin/clavulanate for treating pneumonia in hospitalized patients aged 65 and older. This research may help determine the best antibiotic treatment for older adults.

Community-Acquired Pneumonia in Elderly Patients>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesInfectious DiseasesPulmonology

Advanced Solid Tumors: BMS-986340 Treatment Study

We are testing a new treatment called BMS-986340, both alone and with other medications, for people with advanced solid tumors. The goal is to assess its safety and how well it may work against cancer.

Advanced Cancer>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesOncology

Hidradenitis Suppurativa: Upadacitinib Study

We are testing Upadacitinib in adults and adolescents with moderate to severe Hidradenitis Suppurativa who haven't responded to other treatments. The goal is to see if it is more effective and safe than a placebo.

Hidradenitis Suppurativa>2 yearsConfirmation phase (III)16-20 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteDermatology

Dementia Care: Benefits of Amyloid PET Imaging

We are exploring how amyloid PET imaging may improve care for people with dementia compared to standard diagnostic methods. This study aims to show its impact on important health outcomes.

Dementia>2 yearsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesPartially RemoteNeurologyPsychiatry

Elderly Surgery: Comparing Anesthesia Methods

We are studying how desflurane, sevoflurane, and propofol affect the risk of delirium and cognitive function in elderly patients after major abdominal surgery. This research aims to improve recovery outcomes for older adults undergoing surgery.

Postoperative Delirium>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesPartially Remote

Fludarabine in Stem Cell Transplantation

We are studying how Fludarabine exposure varies among patients receiving reduced intensity stem cell transplants. The goal is to understand its effects on long-term health and potential side effects.

Patients Undergoing Stem Cell Transplant for Blood Cancer>2 yearsMonitoring phase (IV)No PlaceboInvestigational MedicinesHematologyOncology

Splenic Marginal Zone Lymphoma: Rituximab with Zanubrutinib

We are comparing the effects of adding zanubrutinib to rituximab versus using rituximab alone in patients with untreated splenic marginal zone lymphoma. The goal is to see if the combination improves survival and response rates.

Splenic Marginal Zone Lymphoma>2 yearsConfirmation phase (III)11-15 visitsNo PlaceboStandard MedicinesOncology

Solid Tumors: Investigational Drug THE-0504

We are assessing the safety and tolerability of THE-0504 for patients with solid tumors. This trial aims to understand how well the drug is tolerated by participants.

Solid Tumors>2 yearsSafety phase (I)Oncology

Advanced Non-Small Cell Lung Cancer: BAY2927088 Study

We are testing a new treatment for patients with advanced NSCLC who have mutations in the EGFR and/or HER2 genes. This study aims to explore its effects on cancer progression.

Advanced Non-Small Cell Lung Cancer>2 yearsSafety phase (I)Efficacy phase (II)OncologyPulmonology