Search Clinical Trials in the European Union

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401-420 of 552 trials

Chronic Low Back Pain: Antibiotic Treatment Study

We are studying whether a three-month course of amoxicillin can help people with chronic low back pain and specific MRI changes. This trial compares the antibiotic treatment to a placebo to see if it offers any benefits.

Non-Specific Low Back Pain1-2 yearsMonitoring phase (IV)≤5 visitsPost-Trial Drug AccessStandard MedicinesInfectious DiseasesOrthopedics and Traumatology

Clindamycin for Infections: Impact of Rifampicin and Obesity

We are studying how body weight and the antibiotic rifampicin affect the effectiveness of clindamycin in treating infections. This research may help improve treatment strategies for patients with varying body types.

Hidradenitis SuppurativaProsthetic Joint InfectionsFracture Related Infections≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesCost ReimbursementInfectious DiseasesInternal Medicine

Histiocytosis: Fludeoxyglucose (18F-FDG) Imaging Study

We are examining how fludeoxyglucose (18F-FDG) in PET/CT scans can help monitor juvenile patients with histiocytosis. The study will assess its safety and potential benefits for those with specific mutations.

Erdheim-Chester DiseaseLangerhans Cell SarcomaRosai-Dorfman Syndrome>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesHematologyOtolaryngology

Atrial Fibrillation After CABG: Anticoagulant Study

We are studying whether adding anticoagulant medications helps prevent blood clots in patients with new-onset atrial fibrillation after heart surgery. This trial aims to ensure safety and effectiveness in managing this condition.

Atrial FibrillationNew-Onset Post-Operative Atrial Fibrillation after CABG6-12 monthsMonitoring phase (IV)No PlaceboInvestigational MedicinesPartially RemoteCardiologyInternal Medicine

Mitral Valve Surgery: Landiolol Study

We are investigating whether Landiolol can help improve heart function and reduce complications after mitral valve surgery. This study looks at its effects on heart health and recovery in patients undergoing this procedure.

Low Cardiac Output Syndrome>2 yearsMonitoring phase (IV)Investigational MedicinesCardiologyInternal Medicine

Dystonia: Botulinum Toxin for Arm Tremors

We are exploring how different tests and imaging techniques can help determine the effectiveness of botulinum toxin for treating arm tremors in people with dystonia. This study aims to improve treatment options for those affected.

Dystonic Tremor Syndrome6-12 monthsMonitoring phase (IV)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementNeurology

Cardiac Arrest: Ketamine vs. Propofol Sedation

We are studying whether ketamine sedation can better protect the brain and improve survival compared to propofol in patients resuscitated from cardiac arrest. This trial looks at outcomes at discharge and 180 days later.

Out-of-Hospital Cardiac Arrest1-2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesPartially RemoteCardiologyNeurology

Post-Surgical Hypoparathyroidism: Indapamide Treatment

We are studying whether daily Indapamide can help manage calcium levels in patients with post-surgical hypoparathyroidism. This trial will also look at the safety of the treatment and its effects on urinary calcium excretion.

Hypoparathyroidism≤3 monthsMonitoring phase (IV)6-10 visitsStandard MedicinesCost ReimbursementEndocrinologyInternal Medicine

Crohn's Disease: Adalimumab Treatment Study

We are comparing a new approach using adalimumab for newly diagnosed Crohn's disease patients against standard treatments. The goal is to see which method is safer and more effective in the long run.

Crohn's Disease3-6 monthsMonitoring phase (IV)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteGastroenterologyInternal Medicine

Efgartigimod for Early Treatment of Generalized Myasthenia Gravis

We are studying whether efgartigimod can improve daily activities and quality of life for patients with generalized myasthenia gravis and specific antibodies. This trial will help us understand its effectiveness and tolerability as an early treatment option.

Generalized Myasthenia Gravis6-12 monthsMonitoring phase (IV)11-15 visitsNo PlaceboStandard MedicinesPartially RemoteNeurology

Serotonin and Decision-Making: A Behavioral Study

We are investigating how serotonin influences learning and decision-making in individuals. The study also looks at how personal traits like perfectionism and impulsivity relate to these behaviors.

Healthy Participants≤3 monthsMonitoring phase (IV)≤5 visitsStandard MedicinesPsychiatry

Anesthesia in Newborns: Propofol vs. Thiopental

We are studying the right doses of propofol and thiopental for safely inducing anesthesia in newborns. The trial also examines how these drugs affect breathing and heart function.

Neonates Undergoing General Anesthesia>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOtolaryngologyPediatrics

ANCA-Vasculitis: Corticosteroid Dosing Study

We are investigating if taking corticosteroids twice daily helps patients with ANCA-vasculitis maintain better blood sugar levels. This study will measure glucose control using continuous monitoring.

ANCA-associated VasculitisRapid-Progressive Glomerulonephritis≤3 monthsConfirmation phase (III)Monitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesEndocrinologyRheumatology

Stroke Prevention: ASPIRING Study

We are investigating if an oral antiplatelet drug can help prevent serious heart and brain events in stroke survivors. This study compares the effects of this medication to standard care without antiplatelet drugs.

Intracerebral Hemorrhage>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCost ReimbursementPartially RemoteCardiologyInternal MedicineNeurology

Intensive Care: INCEPT Trial

We are studying different treatments for adults admitted to the intensive care unit to see how they affect recovery. This trial aims to improve care by understanding the best practices among clinicians.

Intensive Care>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyInfectious DiseasesInternal MedicineNeurologyPulmonology

Prucalopride for Refractory Gastro-Esophageal Reflux Disease

We are testing a new medication for patients with GERD who still have symptoms despite taking standard treatments. The goal is to see if this drug can improve their reflux symptoms.

Gastro-esophageal Reflux Disease (GERD)≤3 monthsMonitoring phase (IV)≤5 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementPartially RemoteGastroenterologyInternal Medicine

Pediatric Hip Surgery: Tranexamic Acid Study

We are testing whether tranexamic acid can reduce blood loss during hip surgeries in children. This study aims to see if it helps improve recovery and reduces the need for blood transfusions.

Slipped Capital Femoral Epiphysis (SCFE)Legg-Calvé-Perthes Disease (LCPD)Neuromuscular ConditionsMonitoring phase (IV)Standard MedicinesOrthopedics and TraumatologyPediatrics

Heart Health: Treatment for Frequent PVCs

We are studying whether treating asymptomatic patients with frequent PVCs can prevent future heart function problems. This trial compares treatment options to simple monitoring to see which is more effective.

Premature Ventricular Contractions (PVCs)>2 yearsConfirmation phase (III)Monitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesCardiologyInternal Medicine

Sedation Study: Remimazolam vs. Midazolam for GI Endoscopy

We are comparing two sedation medications to see which one helps patients recover faster after upper GI endoscopy. We’ll also look at patient satisfaction and any side effects.

Healthy ParticipantsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyInternal MedicineOtolaryngology

Beta-Lactam Antibiotics: Precision Dosing in Critically Ill Children

We are studying a new dosing method for beta-lactam antibiotics in critically ill children to see if it helps them reach treatment goals faster than standard dosing. This may also help reduce their time in the hospital.

Systemic Infections>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInfectious DiseasesPediatrics