Search Clinical Trials in the European Union

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581-600 of 653 trials

Bladder Cancer: New Treatment Combination Study

We are investigating a new treatment combining chemotherapy and immunotherapy with radiotherapy for patients with non-metastatic muscle invasive bladder cancer. The goal is to see if this approach improves survival and quality of life after surgery.

Non-Metastatic Muscle Invasive Bladder Cancer1-2 yearsEfficacy phase (II)16-20 visitsNo PlaceboStandard MedicinesOncologyUrology

Riluzole for Spinocerebellar Ataxia Type 7

We are studying whether Riluzole can help patients with Spinocerebellar Ataxia type 7 maintain their stability in symptoms and visual function. This trial will also assess the safety and tolerability of the medication.

Spinocerebellar Ataxia Type 7 (SCA7)1-2 yearsEfficacy phase (II)6-10 visitsInvestigational MedicinesInternal MedicineNeurology

Autoimmune Diseases: VIS171 Treatment

We are testing a new treatment called VIS171 for individuals with autoimmune diseases. The study aims to evaluate its safety and how the body reacts to it.

Alopecia AreataSystemic Lupus ErythematosusImmune-Mediated Focal Segmental Glomerulosclerosis1-2 yearsSafety phase (I)Infectious DiseasesInternal Medicine

Ulcerative Colitis: Comparing Risankizumab and Vedolizumab

We are studying whether risankizumab is more effective and safe than vedolizumab for adults with moderate to severe ulcerative colitis who have not yet received targeted treatments.

Ulcerative Colitis1-2 yearsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementGastroenterologyInternal Medicine

Hypertension and Obesity: Orforglipron Study

We are investigating a new medication, Orforglipron, for people with hypertension who are also overweight or obese. The goal is to see if it can safely help manage their blood pressure.

High Blood Pressure1-2 yearsConfirmation phase (III)Investigational MedicinesPartially RemoteEndocrinologyInternal Medicine

Chronic Heart Failure: Ferric Derisomaltose Treatment

We are studying whether ferric derisomaltose can improve heart health and reduce hospitalizations in people with iron deficiency and chronic heart failure. This trial compares it to no intravenous iron treatment.

Chronic Heart Failure1-2 yearsConfirmation phase (III)11-15 visitsInvestigational MedicinesCost ReimbursementPartially RemoteCardiologyInternal Medicine

Felzartamab for Kidney Transplant Recipients with Late Antibody-Mediated Rejection

We are studying whether felzartamab can improve outcomes for kidney transplant recipients facing late antibody-mediated rejection. This trial compares the new treatment to a placebo to assess its effectiveness and safety.

Kidney Transplant Rejection1-2 yearsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessInvestigational MedicinesNephrology

Tozorakimab for Uncontrolled Asthma

We are studying whether different doses of tozorakimab can help adults with uncontrolled asthma reduce severe attacks. This trial compares the medication to a placebo to evaluate its effectiveness and safety.

Asthma1-2 yearsEfficacy phase (II)Investigational MedicinesPartially RemoteAllergologyPulmonology

HER2 Cancers: IAM1363 Treatment Study

We are testing IAM1363 in patients with HER2-positive cancers to see how safe it is and to find the right dosage. This study aims to gather important information for future treatments.

HER2 Gene Amplification1-2 yearsSafety phase (I)Oncology

Ravulizumab Dosing for PNH Patients

We are studying whether personalized dosing of ravulizumab is more effective than standard dosing for adults with PNH. This trial also looks at patient preferences and treatment costs.

Paroxysmal Nocturnal Hemoglobinuria1-2 yearsMonitoring phase (IV)Post-Trial Drug AccessNo PlaceboStandard MedicinesHematologyInternal Medicine

PF-07985631: Tolerance Study in Healthy Adults

We are investigating how different amounts of the study medicine PF-07985631 are tolerated by healthy adults. This study will help us understand its effects on the body.

IgA Nephropathy1-2 yearsSafety phase (I)Nephrology

UTI Vaccine Study for Adults Aged 18-64

We are testing a new vaccine to see if it can safely prevent urinary tract infections caused by E. coli in adults, especially women. The study will compare its effectiveness to a placebo.

Urinary Tract Infections1-2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsStandard MedicinesCost ReimbursementPartially RemoteInfectious DiseasesUrology

Low-Grade Upper Tract Urothelial Cancer: UGN-104 Treatment Study

We are studying a new treatment called UGN-104 for patients with low-grade upper tract urothelial cancer. The trial aims to see how well it reduces tumors and its safety compared to existing options.

Low-grade Upper Tract Urothelial Cancer1-2 yearsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementOncologyUrology

PCOS Fertility: Letrozole vs. Gonadotropins

We are studying whether continuing ovulation induction with letrozole is more effective than switching to gonadotropins for women with polycystic ovary syndrome. The trial also looks at safety, quality of life, and costs related to fertility treatment.

Polycystic Ovary Syndrome (PCOS)1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesPartially RemoteEndocrinologyGynecology and ObstetricsInternal Medicine

Severe Asthma: Verekitug (UPB-101) Study

We are studying the long-term safety and effects of verekitug in adults with severe asthma. This research aims to see how it helps manage asthma attacks and improve breathing.

Severe Asthma1-2 yearsEfficacy phase (II)11-15 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteAllergologyPulmonology

Choline Chloride for Injection in Intestinal Failure

We are studying the safety and effectiveness of Choline Chloride for Injection in adolescents and adults with intestinal failure. This trial compares the treatment to a placebo to see how well it supports patients receiving long-term parenteral nutrition.

Intestinal Failure1-2 yearsEfficacy phase (II)Confirmation phase (III)16-20 visitsPost-Trial Drug AccessStandard MedicinesGastroenterologyNephrology

Alzheimer's Disease: NPI-001 Study

We are testing a new oral medication, NPI-001, for people aged 50 to 85 with Mild Cognitive Impairment or mild dementia due to Alzheimer's. The study aims to assess its safety and effects on brain health and cognitive function.

Alzheimer's Disease1-2 yearsEfficacy phase (II)11-15 visitsStandard MedicinesPartially RemoteInternal MedicineNeurology

Lung Transplantation: Heparin-Free Heart-Lung Support

We are studying a new method of heart-lung support without blood thinners during lung transplantation. This trial aims to see if it is safe and effective for improving patient outcomes.

Lung Transplantation1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicinePulmonology

LSD Levels in the Brain: Neuroimaging Study

We are investigating how LSD is processed in the human brain using advanced imaging techniques. This research may help us understand its effects on mental health.

Healthy Participants1-2 yearsSafety phase (I)NeurologyPsychiatry

Chronic Rhinosinusitis: Stopping Treatment Study

We are investigating if patients with severe nasal polyps can safely stop treatment after a year without symptoms. We also want to see if one medication works better than the other for achieving this.

Chronic Rhinosinusitis with Nasal Polyps1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesAllergologyOtolaryngology