Search Clinical Trials in the European Union

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901-920 of 1,307 trials

Venous Thromboembolism in Cancer: Abelacimab vs. Dalteparin

We are studying whether a new medication, abelacimab, can effectively prevent blood clots in patients with gastrointestinal or genitourinary cancer. This trial compares it to the standard treatment, dalteparin.

Venous Thromboembolism (VTE)6-12 monthsEfficacy phase (II)Confirmation phase (III)6-10 visitsNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteHematologyOncology

Vibegron for Children with Neurogenic Detrusor Overactivity

We are studying the safety and effectiveness of vibegron in children aged 2 to under 18 with neurogenic detrusor overactivity who use clean intermittent catheterization. This trial aims to understand how well the medication works and how it is processed in young patients.

Neurogenic Bladder1-2 yearsEfficacy phase (II)Confirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesCost ReimbursementPediatricsUrology

Sepsis Treatment: Aminoglycoside Antibiotics and Isolation

We are studying the effects of combining aminoglycoside antibiotics with standard care and the role of protective isolation in critically ill neutropenic patients with sepsis. Our goal is to see how these strategies impact survival and other health outcomes.

Healthy Participants>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesInfectious DiseasesInternal Medicine

Lung Cancer Treatment: CT-P51 vs. Keytruda

We are comparing the effects and safety of CT-P51 and Keytruda in patients with untreated metastatic lung cancer. This study aims to find out if CT-P51 works as well as Keytruda when combined with chemotherapy.

Previously Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer1-2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementOncology

Asthma Treatment in Children: Salbutamol vs. Combination Therapy

We are studying whether using salbutamol alone is as effective as combining it with ipratropium bromide for treating moderate asthma attacks in children. This trial aims to find out which treatment helps reduce hospital admissions and improves recovery.

Acute Asthma Attack>2 yearsConfirmation phase (III)Investigational MedicinesPediatricsPulmonology

Chronic Lymphocytic Leukemia: Lisaftoclax and Acalabrutinib Study

We are testing a new drug combination for patients newly diagnosed with Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma. The study aims to see if this combination improves survival without disease progression compared to standard treatments.

Chronic Lymphocytic Leukemia (CLL) / Small Cell Lymphocytic Lymphoma (SLL)1-2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesCost ReimbursementHematologyOncology

Intracerebral Hemorrhage: Anticoagulation Strategies

We are studying whether avoiding anticoagulation or using a specific procedure helps improve health outcomes for patients after an intracerebral hemorrhage. We also aim to identify brain markers that may indicate future bleeding risks.

Cerebral Hemorrhage1-2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesInternal MedicineNeurology

Caffeine Treatment for Early Alzheimer's Disease

We are studying whether a 30-week caffeine treatment can help improve thinking and memory in people with early to moderate Alzheimer's disease. This trial compares the effects of caffeine to a placebo to see if it makes a difference.

Alzheimer's Disease6-12 monthsConfirmation phase (III)Investigational MedicinesPartially RemoteNeurology

Hemorrhoidal Disease: RAFAELO® Procedure with Pain Management

We are studying whether adding perianal infiltration during the RAFAELO® procedure helps reduce pain after treatment for hemorrhoids. This trial aims to improve comfort for patients undergoing this procedure.

Hemorrhoids>2 yearsConfirmation phase (III)Monitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesGastroenterologyInternal Medicine

Immunoglobulin A Nephropathy: Povetacicept Study

We are evaluating a new treatment for adults with Immunoglobulin A Nephropathy to see if it helps reduce protein in urine and preserve kidney function. The study also looks at its effects on slowing kidney failure and improving fatigue.

Immunoglobulin A Nephropathy>2 yearsConfirmation phase (III)>20 visitsInvestigational MedicinesCost ReimbursementNephrology

Multiple Myeloma: Elranatamab Combination Therapy

We are studying a new treatment combination for patients with newly diagnosed multiple myeloma who cannot have a transplant. The goal is to see if it works better than a standard treatment option.

Multiple Myeloma>2 yearsConfirmation phase (III)≤5 visitsNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteHematologyOncology

Yellow Fever Vaccination: Comparing Injection Methods

We are studying how different ways of giving the yellow fever vaccine affect the immune response in participants. This trial aims to find out which method may provide better protection and safety.

Yellow Fever3-6 monthsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementInfectious Diseases

ANCA-Associated Vasculitis: Prednisone Treatment Study

We are investigating whether continuing low-dose prednisone helps maintain remission in patients with ANCA-associated vasculitis compared to stopping it after one month. This study will also look at potential side effects and relapse rates over time.

Anti-neutrophil Cytoplasmic Antibody Positive Vasculitis>2 yearsConfirmation phase (III)11-15 visitsInvestigational MedicinesRheumatology

HER2+ Metastatic Colorectal Cancer: Tucatinib Combination Study

We are investigating whether a new treatment combining tucatinib, trastuzumab, and mFOLFOX6 can improve outcomes for patients with HER2+ metastatic colorectal cancer compared to standard care.

Metastatic Colorectal Cancer>2 yearsConfirmation phase (III)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementOncology

Clear Cell Renal Cell Carcinoma: PET Scan Comparison

We are comparing two different PET scans to see which one detects tumors better in patients with clear cell renal cell carcinoma. This study may help improve diagnosis for those suspected of having this type of cancer.

Metastatic Renal Cell Carcinoma≤3 monthsConfirmation phase (III)≤5 visitsNo PlaceboInvestigational MedicinesInternal MedicineOncology

Actinic Keratosis: 5% Potassium Hydroxide Solution

We are studying whether a 5% potassium hydroxide solution is more effective than a placebo for treating mild to moderate actinic keratosis. The trial also looks at the safety of this treatment.

Actinic Keratosis3-6 monthsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessInvestigational MedicinesDermatology

Oxygen Supply After Non-Cardiac Surgery: AIOLOS Trial

We are studying whether providing extra oxygen helps patients maintain better oxygen levels and improves recovery after non-cardiac surgery. This trial compares supplemental oxygen to standard care in the first days post-surgery.

Postoperative Complications Risk after General SurgeryPostoperative Complications Risk after Urology Surgery1-2 yearsConfirmation phase (III)No PlaceboStandard MedicinesInternal MedicinePulmonology

Mixed Dyslipidaemia: Rosuvastatin and Fenofibrate Study

We are comparing two medication combinations to see which one better lowers bad cholesterol in patients with mixed dyslipidaemia at high risk for heart disease. This study will help us understand their effectiveness and safety.

Dyslipidemia3-6 monthsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesCardiologyEndocrinology

Primary Sclerosing Cholangitis: Norucholic Acid Tablets

We are studying the safety and tolerability of norucholic acid tablets for people with primary sclerosing cholangitis. We also want to see if it effectively helps manage their condition.

Primary Sclerosing Cholangitis1-2 yearsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementGastroenterologyHepatology

Ulcerative Pyoderma Gangrenosum: Spesolimab Study

We are testing whether spesolimab can help adults with ulcerative pyoderma gangrenosum heal their skin ulcers better than a placebo. This study aims to evaluate its safety and effectiveness.

Pyoderma GangrenosumConfirmation phase (III)16-20 visitsStandard MedicinesCost ReimbursementDermatology