Search Clinical Trials in the European Union

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Confirmation phase (III)
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1261-1280 of 1,307 trials

Ovarian Cancer: Sentinel Lymph Node Technique Study

We are evaluating a new technique to detect lymph node spread in early-stage ovarian cancer patients. This study aims to see how well it works compared to traditional methods.

Ovarian Cancer>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesGynecology and ObstetricsOncology

Breast Cancer Treatment: Sac-TMT vs. Standard Chemotherapy

We are studying a new treatment for high-risk early-stage breast cancer to see if it works better than standard chemotherapy combined with pembrolizumab. This trial is for individuals with triple-negative or hormone receptor-low positive breast cancer.

Triple Negative Breast Cancer1-2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesCost ReimbursementOncology

Bipolar-I Disorder: KarXT Treatment Study

We are testing a new treatment called KarXT for people experiencing manic episodes in Bipolar-I Disorder. The study aims to see if it helps reduce mania symptoms better than a placebo.

Bipolar Disorder with Mania≤3 monthsConfirmation phase (III)Post-Trial Drug AccessInvestigational MedicinesPsychiatry

Ulcerative Colitis: Mirikizumab with Tirzepatide

We are studying whether combining mirikizumab with tirzepatide helps adults with moderately to severely active ulcerative colitis and obesity achieve better remission and weight loss than mirikizumab alone.

Obesity or OverweightUlcerative Colitis1-2 yearsConfirmation phase (III)16-20 visitsStandard MedicinesPartially RemoteEndocrinologyGastroenterology

Crohn’s Disease: Mirikizumab with Tirzepatide

We are studying whether a combination of mirikizumab and tirzepatide helps adults with moderately to severely active Crohn’s disease achieve better remission and weight loss than mirikizumab alone.

Crohn’s DiseaseObesity or Overweight1-2 yearsConfirmation phase (III)16-20 visitsStandard MedicinesCost ReimbursementPartially RemoteEndocrinologyGastroenterology

Cholangiocarcinoma: Ivosidenib Maintenance Therapy

We are studying whether the drug ivosidenib can help patients with mIDH1 cholangiocarcinoma after standard chemotherapy. The trial will also look at its safety and effects on quality of life.

Cholangiocarcinoma Treatment>2 yearsEfficacy phase (II)Confirmation phase (III)16-20 visitsNo PlaceboStandard MedicinesGastroenterologyOncology

Improving Sleep and Mood in Postmenopausal Women: DHEA and Melatonin Study

We are studying whether a combination of DHEA and melatonin can enhance sleep quality and mood in postmenopausal women. This research may help address sleep issues and mood changes related to menopause.

Menopause and Sleep Disorders≤3 monthsConfirmation phase (III)Standard MedicinesGynecology and ObstetricsInternal MedicinePsychiatry

TAILORED-PROM: Personalized Treatment for Preterm Premature Rupture of Membranes

We are studying if a customized antibiotic and steroid therapy can help prolong pregnancy and improve outcomes for mothers and newborns. This approach may reduce unnecessary antibiotic use compared to standard treatments.

Preterm Premature Rupture of Membranes>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesPartially RemoteGynecology and ObstetricsInfectious Diseases

Bipolar-I Disorder: Long-term Safety of KarXT

We are studying the long-term safety and tolerability of KarXT for people experiencing manic episodes in Bipolar-I Disorder. This trial aims to ensure that the treatment is safe for those affected.

Mania and Bipolar DisorderConfirmation phase (III)16-20 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementPsychiatry

Head and Neck Cancer: New Treatment Approach with Pembrolizumab

We are studying a new sequence of treatments for patients with recurrent head and neck cancer to see if it improves survival compared to standard therapies. We will also evaluate how well patients tolerate the treatments and their quality of life.

Recurrent Head and Neck Squamous Cell Carcinoma>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesOncology

Irritable Bowel Syndrome: Saccharomyces boulardii CNCM I-745

We are studying whether a probiotic can help adults with non-constipated IBS feel better and improve their quality of life compared to a placebo.

Non-constipated Irritable Bowel Syndrome3-6 monthsConfirmation phase (III)≤5 visitsStandard MedicinesCost ReimbursementPartially RemoteGastroenterology

Milsaperidone for Major Depressive Disorder

We are studying whether adding milsaperidone to current antidepressant therapy can improve symptoms in patients with Major Depressive Disorder. The trial also looks at the safety of this new treatment compared to a placebo.

Major Depressive Disorder≤3 monthsConfirmation phase (III)Post-Trial Drug AccessInvestigational MedicinesPsychiatry

Generalized Myasthenia Gravis: Descartes-08 Treatment

We are studying a new treatment called Descartes-08 for people with generalized myasthenia gravis. The trial aims to see if it helps improve daily activities and muscle strength compared to a placebo.

Generalized Myasthenia Gravis3-6 monthsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessInvestigational MedicinesNeurology

Head and Neck Cancer: NBTXR3 Treatment Study

We are studying a new treatment involving NBTXR3 with or without cetuximab for elderly patients with locally advanced head and neck cancer. The goal is to see if this approach improves survival compared to standard radiotherapy.

Head and Neck Cancer>2 yearsConfirmation phase (III)16-20 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteOncology

Spinocerebellar Ataxia SCA27B: Fampridine Study

We are investigating whether fampridine can help improve movement and daily activities in patients with spinocerebellar ataxia SCA27B. This study will also assess its effects on quality of life and overall health.

Spinocerebellar Ataxia1-2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesInternal MedicineNeurology

Platysma Prominence: NT 201 Treatment Study

We are investigating whether NT 201 can safely reduce moderate to severe platysma prominence in adults compared to a placebo. This study aims to find out if this treatment can improve appearance and confidence.

Moderate to Severe Platysma Prominence3-6 monthsConfirmation phase (III)Post-Trial Drug AccessStandard MedicinesDermatology

Heart Disease: AZD0780 Medication Study

We are testing whether AZD0780 can help reduce serious heart and vascular problems in patients with existing heart disease or those at high risk. This study compares AZD0780 to a placebo to see which is more effective.

Atherosclerotic Cardiovascular DiseaseConfirmation phase (III)6-10 visitsInvestigational MedicinesCardiologyInternal Medicine

High 'Bad' Cholesterol: AZD0780 Study

We are investigating how well AZD0780 works for adults with high LDL cholesterol and heart disease or at risk for it. The goal is to see if it can lower cholesterol levels more effectively than a placebo.

High CholesterolAtherosclerotic Cardiovascular Disease1-2 yearsConfirmation phase (III)6-10 visitsInvestigational MedicinesCardiologyInternal Medicine

Major Depressive Disorder: NBI-1065845 Treatment Study

We are evaluating a new medication to see if it helps maintain improvement in people with Major Depressive Disorder. This study looks at its effects on depressive symptoms and overall functioning.

Major Depressive DisorderConfirmation phase (III)Post-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemotePsychiatry

Hidradenitis Suppurativa: Sonelokimab Study

We are studying the long-term safety and effectiveness of sonelokimab for people with moderate to severe hidradenitis suppurativa. This research aims to improve symptoms and quality of life for participants.

Hidradenitis Suppurativa>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementDermatology