Search Clinical Trials in the European Union

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1441-1460 of 2,251 trials

Chronic Kidney Disease: Sevuparin Treatment Study

We are investigating how sevuparin may improve kidney function and anemia in people with chronic kidney disease. The study will assess safety and how the drug works in the body.

Chronic Kidney Disease≤3 monthsEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesPartially RemoteHematologyNephrology

Preventing Constipation After Hip Surgery: Laxative Study

We are exploring which laxatives work best to prevent constipation in patients recovering from hip fracture surgery. This research aims to improve comfort and recovery after surgery.

Hip Fracture>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyOrthopedics and Traumatology

Cluster Headache Study: Understanding Brain Activity

We are exploring how brain activity and receptor availability differ in people with cluster headaches during active and inactive periods. This research may help us learn more about the condition and its effects on the brain.

Nervous System Diseases>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementNeurology

Glucose Distribution in Severely Burned Adults

We are studying how glucose is distributed in the bodies of severely burned adults during their first few days of treatment. This research may help us understand its relationship with other health factors and improve patient care.

Severe Burns>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesEndocrinologyInternal MedicineOrthopedics and Traumatology

Pancreatic Cancer: TCR-Modified T-Cell Therapy

We are studying a new therapy using modified T-cells for adults with advanced pancreatic cancer that has specific genetic mutations. The trial aims to assess safety and how well this treatment may work.

Pancreatic Cancer>2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesCost ReimbursementOncology

Sickle Cell Disease: Gene Therapy with Lovocel

We are studying the long-term safety and effectiveness of a new gene therapy for people with sickle cell disease. This treatment uses modified stem cells to potentially improve health outcomes.

Sickle Cell DiseaseConfirmation phase (III)No PlaceboInvestigational MedicinesHematology

Rectal Cancer: Valproic Acid with Radiotherapy and Capecitabine

We are studying whether adding valproic acid to standard radiotherapy and capecitabine improves tumor response in patients with low to moderate risk rectal cancer before surgery. This trial also examines the impact on survival and quality of life.

Rectal CancerSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesOncology

Opioid Dependency Treatment: Suboxone vs. Methadone

We are comparing the effectiveness of Suboxone and methadone in reducing opioid misuse for patients with chronic pain. The study also looks at how these treatments affect pain relief, well-being, and cognitive function.

Opioid Use Disorder>2 yearsMonitoring phase (IV)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementInternal MedicinePsychiatry

Locally Advanced Rectal Cancer: CApecitabine and Temozolomide Study

We are studying a new treatment combining capecitabine and temozolomide for patients with specific types of locally advanced rectal cancer. The goal is to see if this combination improves tumor response and surgical outcomes.

Locally Advanced Rectal Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Flu Vaccine Study: LAIV in Young Children

We are studying how the LAIV flu vaccine affects the immune response in young children. This research aims to see how well it protects against flu and influences overall health.

Influenza≤3 monthsMonitoring phase (IV)≤5 visitsNo PlaceboInvestigational MedicinesCost ReimbursementPediatricsPulmonology

Metastatic Breast Cancer: Next Generation Sequencing Oncochip

We are studying a new sequencing tool to help decide the best treatment for metastatic breast cancer patients. The goal is to see if it improves survival and response compared to standard chemotherapy.

Breast Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

HIV Treatment: IMC-M113V Study

We are evaluating a new treatment, IMC-M113V, for people with chronic HIV infection who are already on medication. The study will help us understand its safety and how it affects the immune system.

Chronic HIV Infection3-6 monthsSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementInfectious DiseasesInternal Medicine

Hepatocellular Carcinoma: Durvalumab and Tremelimumab with Y-90 SIRT

We are studying a combination of immunotherapy and radiation therapy for patients with intermediate stage liver cancer who cannot have surgery. The goal is to see if this treatment can help shrink tumors and improve survival.

Non-resectable Hepatocellular Carcinoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesPartially RemoteHepatologyOncology

Advanced Breast Cancer: Capivasertib and Fulvestrant Study

We are researching the combination of capivasertib and fulvestrant for patients with HR+/HER2- advanced breast cancer who have not responded to standard treatments. The study aims to evaluate treatment effectiveness and safety in real-world clinical practice.

Advanced Breast Cancer>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteOncology

TBR1-Related Neurocognitive Disorder: Lithium Carbonate Study

We are studying whether lithium carbonate can improve behavior and communication in patients with TBR1-related neurocognitive disorder. This trial will also assess the treatment's safety and overall impact on quality of life.

TBR1 Variant>2 yearsSafety phase (I)Efficacy phase (II)11-15 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteNeurologyPsychiatry

Heart Failure and Kidney Disease: SENEKA Study

We are exploring a new treatment strategy for elderly patients with heart failure and chronic kidney disease to see if it helps manage potassium levels better. This study compares a potassium binder with standard medications to improve patient outcomes.

Chronic Heart Failure and Non-Dialysis Chronic Kidney Disease3-6 monthsConfirmation phase (III)6-10 visitsNo PlaceboInvestigational MedicinesPartially RemoteCardiologyInternal MedicineNephrology

Sickle Cell Disease: CTX001 Treatment for Kids

We are studying a new gene-editing treatment for children with severe sickle cell disease. The trial aims to evaluate its safety and effectiveness in improving their health.

Sickle Cell Anaemia>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementHematologyPediatrics

Influenza Vaccination: Antibody Responses Study

We are investigating how intranasal and intramuscular flu vaccines affect antibody levels in the nose. This research may help improve future vaccination methods.

Healthy Participants≤3 monthsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteInfectious DiseasesPulmonology

RAR-Immune: Nivolumab + Ipilimumab vs. Pazopanib for Advanced Sarcoma

We are studying whether a combination of nivolumab and ipilimumab works better than pazopanib alone for patients with advanced rare sarcomas. This trial will help us understand treatment effectiveness and patient quality of life.

Advanced Rare Sarcomas>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesOncology

Diabetic Macular Edema: Fluocinolone vs. Dexamethasone Implants

We are comparing two eye implants to see which one better improves vision and is more cost-effective for patients with resistant diabetic macular edema. This study also looks at how these treatments affect quality of life.

Diabetic Macular Oedema>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCost ReimbursementOphthalmology