Search Clinical Trials in the European Union

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1981-2000 of 2,120 trials

AL Amyloidosis: Teclistamab Treatment Study

We are investigating whether teclistamab can improve blood health in patients with previously treated AL amyloidosis. This study will also look at the treatment's safety and its effects on quality of life.

Amyloid Light-Chain Amyloidosis>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesHematologyOncology

Blood Cancers: IDP-121 Treatment Study

We are testing a new medication, IDP-121, for patients with relapsed or refractory blood cancers like multiple myeloma and B-cell lymphoma. The goal is to find the best dose and see how well it helps improve patient outcomes.

Chronic Lymphocytic Leukemia (CLL)B-cell LymphomasMultiple Myeloma (MM)6-12 monthsSafety phase (I)Efficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesHematologyOncology

Neoadjuvant Chemo-Immunotherapy for Stage III PD-L1 Positive NSCLC

We are studying a combination of tislelizumab and chemotherapy for patients with stage III PD-L1 positive lung cancer. The aim is to see if this treatment improves surgery success and survival rates.

Stage III Non-Small Cell Lung CancerEfficacy phase (II)No PlaceboStandard MedicinesPartially RemoteOncologyPulmonology

Ravulizumab Dosing for PNH Patients

We are studying whether personalized dosing of ravulizumab is more effective than standard dosing for adults with PNH. This trial also looks at patient preferences and treatment costs.

Paroxysmal Nocturnal Hemoglobinuria1-2 yearsMonitoring phase (IV)Post-Trial Drug AccessNo PlaceboStandard MedicinesHematologyInternal Medicine

Emergency Pain Relief: Sublingual Sufentanil Study

We are investigating whether sublingual sufentanil can effectively manage moderate to severe pain in emergency patients after a single trauma. The study will also assess safety and compare it to standard pain management methods.

Pain in Limb6-12 monthsMonitoring phase (IV)No PlaceboInvestigational MedicinesInternal MedicineOrthopedics and TraumatologyOtolaryngologyPsychiatry

Atrial Fibrillation: Flecainide vs. Amiodarone

We are studying whether flecainide is more effective and safe than amiodarone for treating paroxysmal atrial fibrillation in patients with coronary disease. This trial aims to see if it can restore normal heart rhythm faster and reduce hospital visits.

Coronary Artery DiseaseParoxysmal Atrial Fibrillation>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesCardiologyInternal Medicine

Ketamine for Depression: Brain Imaging Study

We are investigating how different forms of ketamine affect brain function in individuals with depression. This study aims to improve our understanding of how ketamine may help in treating this condition.

Healthy Participants>2 yearsSafety phase (I)Standard MedicinesPsychiatry

Cervical Dystonia: IPN10200 Treatment Study

We are studying the effects of IPN10200 on reducing symptoms of cervical dystonia in adults. This trial will help us understand if it can improve pain and disability compared to a placebo.

Cervical Dystonia6-12 monthsEfficacy phase (II)6-10 visitsInvestigational MedicinesPartially RemoteNeurologyOrthopedics and Traumatology

Non-Small Cell Lung Cancer: Cemiplimab and TEDOPI® Study

We are testing a new combination therapy for patients with non-small cell lung cancer who have not progressed after initial treatment. The goal is to see if this therapy helps clear cancer markers and improves survival compared to standard treatment.

Non-Small Cell Lung Cancer>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesPartially RemoteOncology

Remdesivir for COVID-19 in Kidney Transplant Patients

We are studying whether a 10-day treatment with remdesivir can help kidney transplant recipients with mild or no COVID-19 symptoms avoid severe illness. The trial will also look at the safety and health outcomes of these patients.

COVID-196-12 monthsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesInfectious DiseasesNephrology

Systemic Lupus Erythematosus: CC-97540 CAR T Cell Therapy

We are studying a new CAR T cell therapy for people with active lupus who haven't responded to standard treatments. The goal is to see if it can improve symptoms and overall health.

Systemic Lupus ErythematosusLupus Nephritis>2 yearsEfficacy phase (II)11-15 visitsNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteHematologyRheumatology

Chronic HDV Infection: Tobevibart and Elebsiran Study

We are studying a new combination therapy for people with chronic HDV infection who haven't responded to prior treatment. The goal is to see if this therapy can effectively reduce the virus and improve liver health.

Chronic Hepatitis D Virus Infection>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementHepatologyInfectious Diseases

Psoriatic Arthritis: Lutikizumab and Risankizumab Study

We are testing the effectiveness and safety of a combination of two medications for adults with active psoriatic arthritis. This study aims to see if the combination works better than each medication alone.

Psoriatic Arthritis3-6 monthsEfficacy phase (II)No PlaceboInvestigational MedicinesInternal MedicineRheumatology

UTI Vaccine Study for Adults Aged 18-64

We are testing a new vaccine to see if it can safely prevent urinary tract infections caused by E. coli in adults, especially women. The study will compare its effectiveness to a placebo.

Urinary Tract Infections1-2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsStandard MedicinesCost ReimbursementPartially RemoteInfectious DiseasesUrology

Metastatic Colorectal Cancer: Cetuximab vs. Bevacizumab

We are studying whether continuing cetuximab treatment helps patients with specific types of metastatic colorectal cancer after their first treatment stops working. This trial compares it to another treatment option to see which is more effective.

Metastatic Colorectal CancerConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesOncology

Endometrial Cancer: Sacituzumab Tirumotecan and Pembrolizumab Study

We are studying a combination of sacituzumab tirumotecan and pembrolizumab for people with advanced or recurrent endometrial cancer. The goal is to see if this combination works better than pembrolizumab alone.

Endometrial CarcinomaConfirmation phase (III)Investigational MedicinesCost ReimbursementPartially RemoteInternal MedicineOncology

IgA Nephropathy: Felzartamab Infusions

We are studying the effects of felzartamab infusions on adults with IgA nephropathy to see if it helps reduce protein in urine and improve kidney function compared to a placebo.

IgA Nephropathy>2 yearsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementInternal MedicineNephrology

Oligometastatic Prostate Cancer: Lu-PSMA and Radiotherapy Study

We are investigating whether combining Lu-PSMA with stereotactic radiotherapy improves survival and quality of life for patients with oligometastatic prostate cancer compared to radiotherapy alone.

Metastatic Prostate Cancer3-6 monthsEfficacy phase (II)No PlaceboStandard MedicinesOncologyUrology

Sentinel Node Biopsy: ICG-99mTc-Nanoscan Tracer

We are studying a new hybrid tracer to improve the detection of sentinel nodes in cancer patients. This trial aims to see how well it works compared to traditional methods during preoperative imaging.

Melanoma and Other Head/Neck CancersEfficacy phase (II)No PlaceboStandard MedicinesOncologyOtolaryngology

PCOS Fertility: Letrozole vs. Gonadotropins

We are studying whether continuing ovulation induction with letrozole is more effective than switching to gonadotropins for women with polycystic ovary syndrome. The trial also looks at safety, quality of life, and costs related to fertility treatment.

Polycystic Ovary Syndrome (PCOS)1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesPartially RemoteEndocrinologyGynecology and ObstetricsInternal Medicine