Search Clinical Trials in the European Union

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2001-2020 of 2,120 trials

Personalized Treatment for High-Risk Breast Cancer: PETREMAC Trial

We are studying how personalized therapies can improve outcomes for patients with high-risk breast cancer. The trial looks at treatment responses and aims to enhance surgical options while ensuring safety.

Breast Cancer>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

Glioblastoma: Adding Zoledronic Acid to Treatment

We are studying whether adding zoledronic acid to standard chemotherapy can help improve survival and treatment response in patients with glioblastoma. We also want to assess its safety and tolerability.

Glioblastoma3-6 monthsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesPartially RemoteNeurologyOncology

Severe Asthma: Verekitug (UPB-101) Study

We are studying the long-term safety and effects of verekitug in adults with severe asthma. This research aims to see how it helps manage asthma attacks and improve breathing.

Severe Asthma1-2 yearsEfficacy phase (II)11-15 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteAllergologyPulmonology

Microscopic Colitis: SAR444336 Treatment Study

We are investigating a new treatment, SAR444336, for adults with microscopic colitis in remission. The study aims to see if it can effectively manage symptoms without steroids and evaluate its safety.

Microscopic Colitis6-12 monthsEfficacy phase (II)11-15 visitsInvestigational MedicinesPartially RemoteGastroenterologyInternal Medicine

Choline Chloride for Injection in Intestinal Failure

We are studying the safety and effectiveness of Choline Chloride for Injection in adolescents and adults with intestinal failure. This trial compares the treatment to a placebo to see how well it supports patients receiving long-term parenteral nutrition.

Intestinal Failure1-2 yearsEfficacy phase (II)Confirmation phase (III)16-20 visitsPost-Trial Drug AccessStandard MedicinesGastroenterologyNephrology

Lung Transplantation: Heparin-Free Heart-Lung Support

We are studying a new method of heart-lung support without blood thinners during lung transplantation. This trial aims to see if it is safe and effective for improving patient outcomes.

Lung Transplantation1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicinePulmonology

Prostate Cancer: Androgen Deprivation Therapy and PSMA

We are studying how androgen deprivation therapy affects the expression of a specific protein in metastatic prostate cancer. This research may help us understand treatment responses and disease progression better.

Metastatic Prostate Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncologyUrology

Autoimmune Disease: CAR-Expressing NK Cell Therapy

We are testing a new therapy using engineered immune cells for people with active B-cell driven autoimmune diseases. The study aims to assess safety and effectiveness in conditions like lupus and scleroderma.

Systemic Lupus ErythematosusSystemic SclerosisIdiopathic Inflammatory MyopathySafety phase (I)Efficacy phase (II)16-20 visitsNo PlaceboInvestigational MedicinesInfectious DiseasesRheumatology

Meningococcal Vaccine Study for Ages 10-20

We are testing a booster dose of the rMenB+OMV NZ vaccine in healthy participants aged 10 to 20 who were vaccinated in early childhood. The study aims to see how well it enhances their immune response and evaluates its safety.

Invasive Meningococcal DiseaseConfirmation phase (III)≤5 visitsNo PlaceboInvestigational MedicinesInfectious DiseasesPediatrics

Type 1 Diabetes: Deferoxamine for Hypoxia Response

We are studying whether deferoxamine can improve how people with type 1 diabetes react to low oxygen levels. This trial will help us understand its potential benefits in managing diabetes.

Type 1 Diabetes>2 yearsEfficacy phase (II)6-10 visitsStandard MedicinesEndocrinologyInternal Medicine

Solid Tumors: MK-5684 Study

We are testing a new treatment, MK-5684, for people with certain solid tumors to see if it helps them live longer without disease progression. The study also evaluates its safety and effectiveness compared to standard care.

Breast CancerOvarian CancerEndometrial Cancer6-12 monthsEfficacy phase (II)Confirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesOncology

Rezafungin for Chronic Pulmonary Aspergillosis Treatment

We are studying whether rezafungin can effectively treat chronic pulmonary aspergillosis in adults with few treatment options. The trial will assess both the effectiveness and safety of this medication.

Chronic Pulmonary Aspergillosis6-12 monthsEfficacy phase (II)>20 visitsNo PlaceboStandard MedicinesCost ReimbursementInfectious DiseasesPulmonology

Melanoma Treatment: Comparing Immune Therapies

We are studying two different immune therapy treatments for patients with resectable stage III melanoma. Our goal is to see which treatment may help improve survival without disease progression.

Stage III Malignant MelanomaConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesDermatologyOncology

Metastatic Colorectal Cancer: New Diagnostic Test for Treatment Guidance

We are studying a new test to help doctors determine the best third-line therapy for patients with metastatic colorectal cancer. The goal is to see if this test provides accurate and reliable information for treatment decisions.

Metastatic Colorectal Cancer>2 yearsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesInternal MedicineOncology

Metastatic Melanoma: V940 and Pembrolizumab Study

We are studying a new treatment combining V940 with pembrolizumab for people with metastatic melanoma. The aim is to see if this combination helps improve survival compared to a placebo.

Melanoma>2 yearsEfficacy phase (II)Investigational MedicinesCost ReimbursementOncology

Postoperative Pain Management: Fentanyl Nasal Spray

We are studying a fentanyl nasal spray for pain relief after orthopedic surgery, comparing it to a placebo and standard morphine treatment. The goal is to assess its effectiveness and side effects in managing pain.

Postoperative Pain Relief≤3 monthsConfirmation phase (III)Investigational MedicinesInternal MedicineOrthopedics and TraumatologyPsychiatry

Chronic Rhinosinusitis: Stopping Treatment Study

We are investigating if patients with severe nasal polyps can safely stop treatment after a year without symptoms. We also want to see if one medication works better than the other for achieving this.

Chronic Rhinosinusitis with Nasal Polyps1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesAllergologyOtolaryngology

Head and Neck Cancer: Ficerafusp Alfa with Pembrolizumab

We are studying whether ficerafusp alfa combined with pembrolizumab can effectively treat patients with recurrent or metastatic head and neck cancer. This trial aims to find the best dose and compare its effects to a placebo.

Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma1-2 yearsEfficacy phase (II)Confirmation phase (III)Investigational MedicinesCost ReimbursementOncology

Reducing Complications After Pancreatoduodenectomy: HOP Bundle Study

We are investigating whether a combination of hydrocortisone, octreotide, and a teres ligament patch can help prevent major complications in patients undergoing high-risk pancreatoduodenectomy. This study also looks at its effect on specific complications like pancreatic fistulas.

Resectable Pancreatic Cancer3-6 monthsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOncologyOrthopedics and Traumatology

Oxytocin Infusion: Effects on Sensory Nerves

We are studying how intravenous oxytocin affects sensory nerve responses and cognitive performance in healthy volunteers. This research may help us understand its role in pain perception and inflammation.

Healthy Participants>2 yearsSafety phase (I)≤5 visitsStandard MedicinesNeurologyPsychiatry