Search Clinical Trials in the European Union

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301-320 of 2,120 trials

Community-Acquired Pneumonia: Amoxicillin vs. Amoxicillin/Clavulanate

We are studying whether amoxicillin alone is as effective as amoxicillin/clavulanate for treating pneumonia in hospitalized patients aged 65 and older. This research may help determine the best antibiotic treatment for older adults.

Community-Acquired Pneumonia in Elderly Patients>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesInfectious DiseasesPulmonology

Advanced Solid Tumors: BMS-986340 Treatment Study

We are testing a new treatment called BMS-986340, both alone and with other medications, for people with advanced solid tumors. The goal is to assess its safety and how well it may work against cancer.

Advanced Cancer>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesOncology

Progressive Pulmonary Fibrosis: FAPI-PET Imaging Study

We are exploring if a special imaging method can help identify the type of lung condition in patients with progressive pulmonary fibrosis. This may improve how we understand and treat their disease.

Progressive Pulmonary Fibrosis3-6 monthsSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesPulmonology

Chronic Cutaneous Lupus Erythematosus: Anifrolumab Study

We are investigating whether anifrolumab can improve skin symptoms in adults with chronic cutaneous lupus erythematosus who haven't responded to other treatments. The study will compare its effects to a placebo over 24 weeks.

Cutaneous Lupus Erythematosus1-2 yearsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementPartially RemoteDermatologyRheumatology

Preventing Hearing Loss: ACOU085 for Testicular Cancer Patients

We are studying whether ACOU085 can help prevent hearing loss in testicular cancer patients undergoing treatment with cisplatin. The trial will assess the safety and effectiveness of this treatment through ear injections.

Sensorineural Hearing Loss3-6 monthsEfficacy phase (II)≤5 visitsInvestigational MedicinesOncologyOtolaryngology

Dementia Care: Benefits of Amyloid PET Imaging

We are exploring how amyloid PET imaging may improve care for people with dementia compared to standard diagnostic methods. This study aims to show its impact on important health outcomes.

Dementia>2 yearsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesPartially RemoteNeurologyPsychiatry

Advanced Breast Cancer: Lasofoxifene and Abemaciclib vs. Fulvestrant and Abemaciclib

We are studying two treatment combinations for men and women with advanced breast cancer and an ESR1 mutation. The goal is to see which combination helps patients live longer without disease progression.

Metastatic Breast Cancer1-2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementOncology

Relatlimab and Nivolumab for Young Lymphoma Patients

We are studying a combination of two medications for children and young adults with recurrent or hard-to-treat Hodgkin and Non-Hodgkin lymphoma. The goal is to understand their safety and how well they may work.

Classical Hodgkin Lymphoma and Non-Hodgkin Lymphoma3-6 monthsSafety phase (I)Efficacy phase (II)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteOncologyPediatrics

Elderly Surgery: Comparing Anesthesia Methods

We are studying how desflurane, sevoflurane, and propofol affect the risk of delirium and cognitive function in elderly patients after major abdominal surgery. This research aims to improve recovery outcomes for older adults undergoing surgery.

Postoperative Delirium>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesPartially Remote

Fludarabine in Stem Cell Transplantation

We are studying how Fludarabine exposure varies among patients receiving reduced intensity stem cell transplants. The goal is to understand its effects on long-term health and potential side effects.

Patients Undergoing Stem Cell Transplant for Blood Cancer>2 yearsMonitoring phase (IV)No PlaceboInvestigational MedicinesHematologyOncology

Heart Failure and Obesity: Weight Loss with Semaglutide

We are investigating whether weight loss using semaglutide is more effective than a calorie-restricted diet in improving physical performance for patients with heart failure and obesity. The study also looks at quality of life and heart health impacts from both weight loss methods.

Heart Failure with Reduced Ejection FractionObesity1-2 yearsEfficacy phase (II)11-15 visitsNo PlaceboInvestigational MedicinesPartially RemoteCardiologyDiabetologyEndocrinology

Splenic Marginal Zone Lymphoma: Rituximab with Zanubrutinib

We are comparing the effects of adding zanubrutinib to rituximab versus using rituximab alone in patients with untreated splenic marginal zone lymphoma. The goal is to see if the combination improves survival and response rates.

Splenic Marginal Zone Lymphoma>2 yearsConfirmation phase (III)11-15 visitsNo PlaceboStandard MedicinesOncology

Post-Menopausal Osteoporosis: BP16 vs. EU-Prolia

We are comparing a new treatment, BP16, to EU-Prolia for women with post-menopausal osteoporosis. The study looks at how well each treatment improves bone health and their safety.

Post-Menopausal Osteoporosis1-2 yearsConfirmation phase (III)11-15 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteEndocrinologyRheumatology

Esophageal Cancer Detection: Fluorescent Tracers Study

We are testing a new method using oral fluorescent tracers to help detect early esophageal adenocarcinomas in patients with Barrett's esophagus. This study aims to see if this approach improves detection compared to standard endoscopy.

Barrett's EsophagusEfficacy phase (II)No PlaceboStandard MedicinesGastroenterologyOncology

Mucopolysaccharidosis Type II: DNL310 Treatment Study

We are investigating the long-term safety and effects of DNL310 in patients with MPS II. This study looks at how well the treatment works for cognitive and physical development.

Hunter's Syndrome>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteHematologyNeurology

Bimekizumab for Children with Moderate to Severe Plaque Psoriasis

We are studying how well bimekizumab works compared to ustekinumab in children and teens aged 6 to under 18 with moderate to severe plaque psoriasis. The trial will also look at safety and quality of life improvements.

Plaque PsoriasisConfirmation phase (III)Post-Trial Drug AccessStandard MedicinesAllergologyDermatology

Cardiovascular Collapse: Vasopressor Use During Intubation

We are studying whether giving vasopressors before intubation helps prevent cardiovascular collapse in critically ill adults. This research aims to improve safety during a critical medical procedure.

Critical Illness>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesCardiologyInternal Medicine

Locally Advanced NSCLC: Alectinib vs. Durvalumab

We are studying whether alectinib or entrectinib is more effective than durvalumab for patients with advanced non-small cell lung cancer who have not progressed after initial treatment. The trial also looks at quality of life and safety for participants.

Non-Small Cell Lung Cancer>2 yearsConfirmation phase (III)>20 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteOncology

Ectopic Pregnancy: Mifepristone and Letrozole vs. Methotrexate

We are studying whether a new combination treatment is as effective as the standard medication for ectopic pregnancy. This trial will also look at side effects and the need for further medical interventions.

Ectopic Pregnancy>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesGynecology and Obstetrics

Pneumonia: TAD® Treatment Study

We are testing whether TAD®, an intravenous treatment, can help prevent heart injury in hospitalized patients with pneumonia. This study aims to evaluate its safety and effectiveness as an additional therapy.

Heart Injury from Pneumonia1-2 yearsConfirmation phase (III)≤5 visitsNo PlaceboInvestigational MedicinesPartially RemoteCardiologyInternal MedicinePulmonology