Search Clinical Trials in the European Union

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261-280 of 1,782 trials

Severe Epilepsy: Cannabidiol Oral Solution

We are studying whether Cannabidiol can help reduce seizures in children and young adults with rare disease-related severe epilepsy. The trial also looks at safety and how it interacts with current medications.

Epilepsy3-6 monthsEfficacy phase (II)No PlaceboStandard MedicinesNeurologyPediatrics

Parkinson's Disease: Safinamide vs. Rasagiline for Fatigue

We are studying whether Safinamide or Rasagiline can help reduce fatigue in people with Parkinson's Disease already on stable treatment. The trial will also monitor safety and side effects over six months.

Fatigue in Parkinson's Disease3-6 monthsMonitoring phase (IV)No PlaceboStandard MedicinesPartially RemoteNeurology

Relatlimab and Nivolumab for Young Lymphoma Patients

We are studying a combination of two medications for children and young adults with recurrent or hard-to-treat Hodgkin and Non-Hodgkin lymphoma. The goal is to understand their safety and how well they may work.

Classical Hodgkin Lymphoma and Non-Hodgkin Lymphoma3-6 monthsSafety phase (I)Efficacy phase (II)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteOncologyPediatrics

Elderly Surgery: Comparing Anesthesia Methods

We are studying how desflurane, sevoflurane, and propofol affect the risk of delirium and cognitive function in elderly patients after major abdominal surgery. This research aims to improve recovery outcomes for older adults undergoing surgery.

Postoperative Delirium>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesPartially Remote

Splenic Marginal Zone Lymphoma: Rituximab with Zanubrutinib

We are comparing the effects of adding zanubrutinib to rituximab versus using rituximab alone in patients with untreated splenic marginal zone lymphoma. The goal is to see if the combination improves survival and response rates.

Splenic Marginal Zone Lymphoma>2 yearsConfirmation phase (III)11-15 visitsNo PlaceboStandard MedicinesOncology

Post-Menopausal Osteoporosis: BP16 vs. EU-Prolia

We are comparing a new treatment, BP16, to EU-Prolia for women with post-menopausal osteoporosis. The study looks at how well each treatment improves bone health and their safety.

Post-Menopausal Osteoporosis1-2 yearsConfirmation phase (III)11-15 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteEndocrinologyRheumatology

Esophageal Cancer Detection: Fluorescent Tracers Study

We are testing a new method using oral fluorescent tracers to help detect early esophageal adenocarcinomas in patients with Barrett's esophagus. This study aims to see if this approach improves detection compared to standard endoscopy.

Barrett's EsophagusEfficacy phase (II)No PlaceboStandard MedicinesGastroenterologyOncology

Mucopolysaccharidosis Type II: DNL310 Treatment Study

We are investigating the long-term safety and effects of DNL310 in patients with MPS II. This study looks at how well the treatment works for cognitive and physical development.

Hunter's Syndrome>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteHematologyNeurology

Bimekizumab for Children with Moderate to Severe Plaque Psoriasis

We are studying how well bimekizumab works compared to ustekinumab in children and teens aged 6 to under 18 with moderate to severe plaque psoriasis. The trial will also look at safety and quality of life improvements.

Plaque PsoriasisConfirmation phase (III)Post-Trial Drug AccessStandard MedicinesAllergologyDermatology

Endometrial Cancer: Olaparib Maintenance Therapy

We are studying whether olaparib can help prevent cancer recurrence in patients with p53abn endometrial cancer after they receive chemoradiation. This trial compares olaparib treatment to observation alone.

p53abn HREC Patients Post-Surgery>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesPartially RemoteGynecology and ObstetricsOncology

Cardiovascular Collapse: Vasopressor Use During Intubation

We are studying whether giving vasopressors before intubation helps prevent cardiovascular collapse in critically ill adults. This research aims to improve safety during a critical medical procedure.

Critical Illness>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesCardiologyInternal Medicine

Sildenafil for Adults with Univentricular Heart Post-Fontan

We are studying whether adding sildenafil to existing treatments can improve physical performance and quality of life in adults with a univentricular heart after Fontan surgery.

Fontan Procedure and Univentricular Heart3-6 monthsConfirmation phase (III)Standard MedicinesCardiologyHematologyInternal MedicinePediatrics

Locally Advanced NSCLC: Alectinib vs. Durvalumab

We are studying whether alectinib or entrectinib is more effective than durvalumab for patients with advanced non-small cell lung cancer who have not progressed after initial treatment. The trial also looks at quality of life and safety for participants.

Non-Small Cell Lung Cancer>2 yearsConfirmation phase (III)>20 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteOncology

Ectopic Pregnancy: Mifepristone and Letrozole vs. Methotrexate

We are studying whether a new combination treatment is as effective as the standard medication for ectopic pregnancy. This trial will also look at side effects and the need for further medical interventions.

Ectopic Pregnancy>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesGynecology and Obstetrics

Progressive Glioblastoma: Perampanel Treatment Study

We are studying whether the medication Perampanel can help reduce tumor growth in patients with progressive glioblastoma before surgery. This trial also looks at quality of life and cognitive function to see how the treatment affects patients.

Progressive Glioblastoma>2 yearsEfficacy phase (II)Standard MedicinesPartially RemoteNeurologyOncology

Nitroglycerin for Esophageal Food Impaction

We are studying whether nitroglycerin can help relieve food impaction in the esophagus. This trial aims to see if it is an effective treatment for those who have trouble swallowing.

Esophageal Food Impaction>2 yearsEfficacy phase (II)Standard MedicinesGastroenterologyOtolaryngology

Breast Cancer Surgery: ICG Imaging Study

We are exploring how a special imaging technique using ICG dye can help surgeons evaluate cancer margins during breast-conserving surgery. This study aims to find the best timing and dose for the dye to improve surgical outcomes.

Early Invasive Breast Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesGynecology and ObstetricsOncology

Botulinumtoxin A for Myofascial Pain in Temporomandibular Disorders

We are studying whether BTX injections in jaw muscles can effectively reduce pain in patients with temporomandibular disorders. This research may help improve treatment options for those suffering from this condition.

Temporomandibular DisorderConfirmation phase (III)No PlaceboStandard MedicinesOrthopedics and TraumatologyOtolaryngology

Guselkumab for Crohn's Disease Healing

We are studying whether guselkumab can help heal the intestinal wall in patients with Crohn's disease. This research aims to find out how effective it is over 48 weeks.

Crohn's Disease>2 yearsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteGastroenterologyInternal Medicine

Dapagliflozin for Heart Health in Amyloid Transthyretin Cardiac Amyloidosis

We are studying how dapagliflozin may improve exercise capacity and quality of life for patients with ATTR-CA. This trial will also look at its safety and other health markers.

Cardiac Amyloidosis1-2 yearsEfficacy phase (II)No PlaceboStandard MedicinesCardiologyInternal Medicine