Search Clinical Trials in the European Union

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781-800 of 1,782 trials

Cardiac Arrest: Amiodarone Treatment Study

We are investigating whether giving amiodarone to critically ill patients after a cardiac arrest can lower the risk of death and serious heart rhythm problems. This study focuses on patients with a shockable rhythm and aims to improve their outcomes.

Out-of-Hospital Cardiac Arrest>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesCardiologyInternal Medicine

Sufentanil for Pain Management in Abdominal Surgery

We are studying how the use of sufentanil during non-major abdominal surgery affects long-term pain and recovery. This trial looks at both immediate and chronic pain experiences in patients.

Chronic Postsurgical Pain>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyInternal MedicineOtolaryngology

Chronic Lymphocytic Leukemia: Acalabrutinib Treatment Study

We are investigating whether acalabrutinib is safe and effective for adults with chronic lymphocytic leukemia and heart problems. This study compares it to other treatment options available for these patients.

Chronic Lymphocytic Leukaemia with Cardiac Impairment>2 yearsMonitoring phase (IV)16-20 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteCardiologyHematology

Thyroid Eye Disease: Sirolimus vs. Corticosteroids

We are comparing a new treatment called Sirolimus with corticosteroids for people with active thyroid eye disease. The goal is to see if Sirolimus is more effective and has fewer side effects.

Thyroid Eye Disease≤3 monthsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteEndocrinologyOphthalmology

High-Grade Soft Tissue Sarcoma: Ifosfamide and Doxorubicin Study

We are studying a combination of chemotherapy drugs for patients with localized high-grade soft tissue sarcoma. The goal is to see how well this treatment works and to understand its safety and impact on quality of life.

Soft Tissue SarcomaEfficacy phase (II)No PlaceboStandard MedicinesOncology

Overactive Bladder in Children: BeDry Study

We are testing solifenacin, mirabegron, and their combination for treating daytime urinary incontinence in children aged 5 to 14. The study aims to see how well these treatments work and their effects on safety and quality of life.

Daytime Urinary Incontinence3-6 monthsConfirmation phase (III)No PlaceboStandard MedicinesPediatricsUrology

Recurrent Glioblastoma: Personalized Drug Strategy

We are testing a personalized treatment approach for patients with recurrent glioblastoma to see if tailored drug combinations improve tumor response and overall survival. The study also looks at any side effects from the treatments.

Recurrent Glioblastoma1-2 yearsSafety phase (I)No PlaceboStandard MedicinesNeurologyOncology

Bronchiectasis: Inhaled Antibiotics Study

We are studying whether inhaled antibiotics can help reduce bacterial infections in patients with bronchiectasis after initial treatment. This trial compares the effects of inhaled antibiotics to a placebo.

Adult Bronchiectasis1-2 yearsStandard MedicinesInternal MedicinePulmonology

BCR/ABL1-Like Acute Lymphoblastic Leukemia: Ponatinib and Chemotherapy

We are studying a new treatment combining ponatinib and chemotherapy for adults with BCR/ABL1-like acute lymphoblastic leukemia. The aim is to improve remission rates and monitor disease response over time.

Acute Lymphoblastic LeukemiaEfficacy phase (II)No PlaceboStandard MedicinesHematologyOncology

Rheumatoid Arthritis: FBL-MTX Injection Study

We are investigating a new injectable treatment for moderate-to-severe rheumatoid arthritis in patients who haven't used DMARDs or have had issues with oral methotrexate. The study will evaluate how well it works and its safety.

Rheumatoid Arthritis3-6 monthsEfficacy phase (II)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesInternal MedicineRheumatology

Behçet's Syndrome: Steroids Plus Anticoagulants Study

We are investigating whether adding anticoagulants to steroid therapy helps reduce the risk of deep venous thrombosis relapse in people with Behçet's syndrome. This study will also look at safety and quality of life.

Behcet's Syndrome>2 yearsEfficacy phase (II)≤5 visitsStandard MedicinesHematologyInternal MedicineRheumatology

Oral Midazolam for Patients Refusing Care

We are studying whether oral midazolam can help older patients with moderate to severe cognitive disorders accept necessary care. The trial also looks at its safety and the satisfaction of healthcare providers.

Cognitive Issues and Agitation in the Elderly>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesGastroenterologyPsychiatry

Urinary Incontinence in Children: StayDry Study

We are exploring how stopping medication for urinary incontinence affects recurrence and overall well-being in children. The study compares abrupt versus gradual withdrawal of treatments like solifenacin and mirabegron.

Daytime Urinary Incontinence>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesUrology

Chronic Lymphocytic Leukemia: Venetoclax and Pirtobrutinib Study

We are comparing different treatment plans for newly diagnosed chronic lymphocytic leukemia patients to see if a personalized approach improves outcomes. This includes assessing how long patients can stay in remission and the overall effectiveness of the treatments.

Chronic Lymphocytic Leukaemia (CLL)Small Lymphocytic Lymphoma (SLL)>2 yearsConfirmation phase (III)11-15 visitsNo PlaceboStandard MedicinesPartially RemoteHematologyOncology

Chronic Inflammatory Diseases: Low-Dose Interleukin-2 Therapy

We are studying the safety and effectiveness of low-dose interleukin-2 therapy for patients with conditions like Pemphigus vulgaris and Mucous Membrane Pemphigoid. This trial aims to see how well this treatment works compared to a placebo.

Primary Sclerosing Cholangitis (PSC)Mucous Membrane PemphigoidPolymyositis/Dermatomyositis3-6 monthsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementDermatologyInfectious DiseasesRheumatology

Pamidronate for Pain in Sternocostoclavicular Hyperostosis

We are studying whether pamidronate can help reduce pain in patients with sternocostoclavicular hyperostosis. This trial will also look at improvements in daily activities and overall health.

Inflammation of the Sternal RegionSternocostoclavicular Hyperostosis1-2 yearsConfirmation phase (III)≤5 visitsPost-Trial Drug AccessStandard MedicinesOrthopedics and TraumatologyRheumatology

Head and Neck Cancer: Petosemtamab with Pembrolizumab

We are studying a new treatment combination for patients with recurrent or metastatic head and neck cancer to see if it works better than standard treatment. This trial is for those with tumors that express PD-L1.

Metastatic Squamous Cell Carcinoma of the Head and Neck>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesPartially RemoteOncology

Uveal Melanoma: Tebentafusp Treatment Study

We are studying whether the drug tebentafusp can help prevent cancer recurrence in patients with high-risk uveal melanoma after surgery or radiation. This trial also looks at the safety of the treatment compared to observation.

Uveal Melanoma6-12 monthsConfirmation phase (III)No PlaceboStandard MedicinesOncologyOphthalmology

Recurrent Herpes Labialis: Lipovir® Gel vs. Zovirax® Cream

We are studying whether Lipovir® Gel is as effective and tolerable as Zovirax® Cream for treating recurrent herpes labialis. Participants will also receive a placebo to help us understand the treatments better.

Cold Sores≤3 monthsConfirmation phase (III)Standard MedicinesDermatologyInfectious Diseases

Pneumococcal Vaccine Response: Age and HIV Impact

We are studying how age and HIV infection affect the immune response to pneumococcal vaccination. This research aims to improve vaccine effectiveness for different populations.

HIV Infection6-12 monthsConfirmation phase (III)Monitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesCost ReimbursementInfectious DiseasesInternal Medicine