Search Clinical Trials in the European Union

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941-960 of 1,782 trials

Heart Procedure: Protamine Use in Aortic Valve Replacement

We are studying whether protamine can help reduce major bleeding and ischemic events in patients after transcatheter aortic valve replacement. This trial also examines other safety factors and complications related to the procedure.

Transcatheter Aortic Valve Replacement (TAVR)>2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesPartially RemoteCardiologyInternal Medicine

Dornase Alfa for Severe Trauma Patients in ICU

We are studying whether inhaled dornase alfa can help reduce serious lung complications in ventilated patients with severe trauma. This trial aims to see if it lowers the risk of ARDS and improves recovery outcomes.

Severe TraumaConfirmation phase (III)Standard MedicinesInternal MedicinePulmonology

Gentamicin Injection for Cat Scratch Disease Lymphadenitis

We are studying whether an injection of gentamicin can improve symptoms in patients with cat scratch disease lymphadenitis compared to a placebo. This trial also looks at pain relief and lymph node changes over time.

Bartonellosis≤3 monthsConfirmation phase (III)≤5 visitsStandard MedicinesInfectious DiseasesInternal Medicine

Inhaled Molgramostim for Pediatric Autoimmune Pulmonary Alveolar Proteinosis (aPAP)

We are studying the effects of inhaled molgramostim in children and teens with aPAP. The goal is to see if it is safe and effective for improving their condition.

Pulmonary Alveolar Proteinosis1-2 yearsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPediatricsPulmonology

Progressive Vitiligo: Anifrolumab and Phototherapy Study

We are investigating whether combining anifrolumab with phototherapy helps adults with progressive vitiligo regain skin color better than phototherapy alone. The study will also assess the safety and tolerability of this new treatment approach.

Vitiligo6-12 monthsEfficacy phase (II)Standard MedicinesAllergologyDermatology

Prostate Cancer: Re-treatment with [177Lu]Lu-PSMA

We are studying the effects of re-treating men with metastatic castration-resistant prostate cancer using [177Lu]Lu-PSMA. This trial aims to see if this treatment can help improve survival and quality of life.

Metastatic Prostate Cancer>2 yearsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesOncologyUrology

Head and Neck Cancer: Cetuximab with Chemotherapy

We are studying a combination of cetuximab and chemotherapy followed by immunotherapy for patients with recurrent or metastatic head and neck cancer. The goal is to see if this treatment improves survival and response rates for those with a specific PD-L1 score.

Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesCost ReimbursementPartially RemoteOncology

Apixaban in Short Bowel Syndrome Patients

We are studying how the blood levels of apixaban differ in patients with short bowel syndrome who require long-term IV nutrition. This research may help improve treatment strategies for these patients.

Short Bowel Syndrome>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyInternal Medicine

Haemophilia A: Efanesoctocog Alfa Treatment Study

We are investigating how efanesoctocog alfa affects joint health in patients with haemophilia A. The study aims to understand improvements in joint swelling and overall health during treatment.

Haemophilia A1-2 yearsMonitoring phase (IV)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteHematologyOrthopedics and Traumatology

Sleeping through Menopause: Hormone Therapy and Online Sleep Support

We are studying whether hormone therapy and a guided online sleep program can help improve sleep and mood in perimenopausal women. This trial aims to enhance mental health and overall well-being during this transition.

InsomniaClimacteric Symptoms3-6 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteGynecology and ObstetricsPsychiatry

Neurocritical Patients: Inhalation vs. Intravenous Sedation

We are studying whether inhalation sedation with isoflurane is more effective and safer than conventional intravenous sedation for patients in critical neurological care. This trial will help us understand the best sedation methods for these patients.

Pain ReliefMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineNeurologyOtolaryngology

Glucothera Plus for Children on Peritoneal Dialysis

We are studying the safety of Glucothera Plus in children receiving peritoneal dialysis. We also want to see if it helps restore L-carnitine levels in these patients.

End-stage Kidney Disease6-12 monthsConfirmation phase (III)No PlaceboStandard MedicinesNephrologyPediatrics

Irritable Bowel Syndrome: Symbioflor®2 Treatment

We are studying an oral treatment with living bacteria for people with diarrhea-predominant irritable bowel syndrome (IBS-D). The goal is to see if it helps reduce symptoms compared to a placebo.

Irritable Bowel Syndrome6-12 monthsMonitoring phase (IV)6-10 visitsStandard MedicinesCost ReimbursementGastroenterology

Pain Management After Colorectal Surgery: Continuous Wound Infusion Study

We are investigating whether continuous infusion of local pain relief helps patients recover better after minimally invasive colorectal surgery. The study compares this method to a placebo to see its effects on pain and recovery time.

Recovery After Colorectal Surgery1-2 yearsConfirmation phase (III)Standard MedicinesGastroenterologyInternal MedicineOtolaryngology

Brain Surgery Pain Management: Nerve Block Comparison

We are comparing two types of nerve blocks to see which one helps reduce pain and improve recovery for patients undergoing brain surgery. This study aims to find the best option for managing discomfort during the procedure.

Patients Undergoing Craniotomy for Supratentorial Mass>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineNeurologyOtolaryngology

Severe Asthma: Tezepelumab Medication Study

We are studying if tezepelumab can help patients aged 12 to 80 with severe asthma reduce their daily medication while keeping their symptoms under control.

Severe Asthma1-2 yearsConfirmation phase (III)16-20 visitsNo PlaceboStandard MedicinesCost ReimbursementInternal MedicinePulmonology

Colorectal Cancer: Encorafenib and Cetuximab with Pembrolizumab

We are studying a combination of medications for patients with BRAF V600E-mutant metastatic colorectal cancer. The goal is to see if this combination works better than pembrolizumab alone.

Metastatic Colorectal Cancer>2 yearsEfficacy phase (II)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteOncology

Pancreatic Cancer: Digitoxin and Chemotherapy Study

We are exploring whether adding digitoxin to chemotherapy can help improve survival for patients with inoperable pancreatic cancer. The trial also looks at treatment safety and quality of life.

Pancreatic Cancer6-12 monthsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesOncology

Cognitive and Motor Function Study: Donepezil in Older Adults

We are investigating whether a medication can improve thinking and movement tasks in elderly volunteers. This study compares the effects of donepezil to a placebo on brain activity and performance.

Neurological Disorders≤3 monthsEfficacy phase (II)≤5 visitsStandard MedicinesCost ReimbursementNeurology

Advanced Non-Small Cell Lung Cancer: PD-1 Inhibitor with Chemotherapy and Radiation

We are studying whether adding radiation to a PD-1 inhibitor and chemotherapy improves survival and tumor response in patients with advanced non-small cell lung cancer. This trial also looks at side effects and quality of life.

Advanced Non-Small Cell Lung Cancer (NSCLC)3-6 monthsConfirmation phase (III)No PlaceboStandard MedicinesOncology