Search Clinical Trials in the European Union

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1581-1600 of 1,782 trials

Immunotherapy for MSI/dMMR Tumors: Pembrolizumab Study

We are studying the effects of pembrolizumab in patients with untreated localized MSI/dMMR tumors or EBV+ gastric cancer. The goal is to see if this treatment improves outcomes before and after surgery.

MSI/dMMR Tumors and EBV+ Gastric Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Moderate Atopic Dermatitis: Ruxolitinib Cream for Kids

We are studying a new cream for children and adolescents aged 6 to under 18 with moderate atopic dermatitis who haven't had success with other treatments. The trial will assess how well it works and its safety.

Atopic Dermatitis1-2 yearsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementPartially RemoteAllergologyDermatology

EGFR-Mutated Lung Cancer: ERIS Study

We are exploring the best sequence of EGFR-inhibitors for patients with EGFR-mutated lung cancer. The study also examines treatment effects, side effects, and quality of life.

EGFR-Mutated Non-Small Cell Lung Cancer>2 yearsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesOncology

Heart Attack Treatment: Evolocumab vs. Standard Care

We are studying whether the medication evolocumab can better prevent heart-related problems compared to standard treatments for patients who have recently had a heart attack. This trial focuses on improving cholesterol control and reducing hospitalizations.

Heart Attack>2 yearsMonitoring phase (IV)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteCardiologyInternal Medicine

Ketamine Therapy for Obsessive-Compulsive Disorder

We are studying whether ketamine can effectively reduce symptoms of obsessive-compulsive disorder. This trial will help us understand its impact on mental function during stressful situations.

Obsessive Compulsive Disorder (OCD)≤3 monthsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemotePsychiatry

Growth Hormone and Liver Fat Metabolism Study

We are investigating how growth hormone influences fat processing in the liver of healthy adults. Additionally, we will explore its effects in patients with acromegaly to understand fat secretion better.

AcromegalyHealthy Participants≤3 monthsEfficacy phase (II)No PlaceboStandard MedicinesEndocrinologyHepatology

Non-Small Cell Lung Cancer: Drug Sequencing Study

We are investigating the best order to use two medications for patients with advanced non-small cell lung cancer that has specific mutations. This study aims to see which treatment sequence may improve outcomes for these patients.

Non-small Cell Lung Cancer (NSCLC)>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Metastatic Non-Small-Cell Lung Cancer: Tedopi Combinations

We are studying the effects of Tedopi combined with either docetaxel or nivolumab in patients with advanced lung cancer who have not responded to previous treatments. This trial aims to see if these combinations can improve survival rates and overall health.

Metastatic Non-Small-Cell Lung Cancer1-2 yearsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesOncology

Dopamine Changes in Depression: Escitalopram vs. Bupropion

We are studying how rewards affect dopamine levels in the brain of people with major depressive disorder compared to healthy volunteers. This trial also looks at how two different antidepressants may influence these changes.

Major Depression>2 yearsMonitoring phase (IV)11-15 visitsNo PlaceboStandard MedicinesPsychiatry

Heart Failure Treatment: Sacubitril/Valsartan vs. Ramipril

We are studying how two heart medications affect heart function in patients with ischemic heart failure. Our goal is to see which treatment better helps improve heart structure and performance.

Congestive Heart Failure1-2 yearsConfirmation phase (III)Standard MedicinesCardiologyInternal Medicine

Zinc Acexamate for Advanced Chronic Liver Disease

We are studying whether Zinc Acexamate can improve health outcomes for patients with advanced chronic liver disease. This trial compares its effects to a placebo to see if it reduces complications and improves survival.

Advanced Chronic Liver Disease>2 yearsConfirmation phase (III)Standard MedicinesHepatologyInternal Medicine

Acute Myeloid Leukemia: NOPHO-DBH AML 2012 Study

We are researching new treatment options for children and adolescents with acute myeloid leukemia. The goal is to find more effective therapies while reducing side effects and improving overall outcomes.

Acute Myeloid Leukemia>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesOncologyPediatrics

Psychiatric Disorders: Immunotherapy Study

We are testing whether immunotherapy can help patients with psychotic symptoms and autoimmune conditions when added to their ongoing psychiatric care. This study aims to improve understanding of treatment options for these patients.

Mental Disorder1-2 yearsConfirmation phase (III)No PlaceboStandard MedicinesPsychiatry

Primary Plasma Cell Leukemia: New Treatment with Bortezomib and Daratumumab

We are studying a combination of medications for people with primary plasma cell leukemia to see if it improves treatment outcomes and safety. This trial will help us understand how well this new approach works compared to current treatments.

Plasma Cell Leukemia>2 yearsEfficacy phase (II)>20 visitsNo PlaceboStandard MedicinesHematologyOncology

Polymyalgia Rheumatica: Hydrocortisone Supplement Study

We are investigating whether supplemental hydrocortisone helps improve quality of life for patients with polymyalgia rheumatica or giant cell arteritis experiencing adrenal insufficiency. The focus is on how it affects fatigue during stress.

Glucocorticoid Induced Adrenal Insufficiency6-12 monthsMonitoring phase (IV)6-10 visitsStandard MedicinesCost ReimbursementPartially RemoteEndocrinologyRheumatology

Multiple Sclerosis: CBD for Sleep Quality

We are investigating whether cannabidiol (CBD) can improve sleep quality in patients with multiple sclerosis. This study aims to help those struggling with sleep issues related to their condition.

Insomnia3-6 monthsEfficacy phase (II)6-10 visitsStandard MedicinesPartially RemoteInternal MedicineNeurology

Lung Health: Avalyn Inhaled Antifibrotic Study

We are studying the long-term safety and effects of Avalyn's inhaled antifibrotic medications on lung function in patients who have previously participated in related trials.

Pulmonary FibrosisEfficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemotePulmonology

Cirrhosis: Carvedilol for Preventing Digestive Bleeding

We are studying whether Carvedilol can help prevent digestive bleeding in patients with cirrhosis. The trial measures its effects on liver pressure and overall tolerance over three months.

Cirrhotic Portal Hypertension3-6 monthsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesGastroenterologyInternal Medicine

Fertility Study: Metformin for Women Post-Thyroid Cancer

We are evaluating whether metformin can improve fertility in women treated with radioactive iodine for thyroid cancer. The study will look at hormone levels and ovarian health to see how effective the treatment is.

Papillary Thyroid Carcinoma1-2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesGynecology and ObstetricsOncology

Esophageal Cancer: Tislelizumab for Elderly Patients

We are studying Tislelizumab to see if it helps elderly patients with advanced esophageal cancer who cannot receive chemotherapy. The trial aims to assess survival rates and quality of life improvements.

Esophageal Squamous Cell Carcinoma3-6 monthsEfficacy phase (II)No PlaceboStandard MedicinesOncology