Search Clinical Trials in the European Union

Duration
Visits
Phase
Intake methods
Standard Medicines
Drugs
Locations
Clinical Specialty
1721-1740 of 1,782 trials

Breast Cancer Treatment: Elacestrant Study

We are studying whether Elacestrant alone is as effective as Elacestrant with ovarian function suppression in premenopausal women with early-stage ER+/HER2- breast cancer. The trial also looks at the safety of these treatment options.

Breast Cancer1-2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesGynecology and ObstetricsOncology

CEB-01 for Pediatric Abdominal Tumors

We are testing a new treatment for children with certain types of abdominal tumors to see if it is safe and effective alongside standard care. This study focuses on children from birth to under 18 years old.

Desmoplastic Small Round Cell TumorFibrolamellar Hepatocellular CarcinomaExtracranial Malignant Rhabdoid Tumor6-12 monthsEfficacy phase (II)16-20 visitsNo PlaceboStandard MedicinesOncologyPediatrics

Bisphosphonate Treatment for Primary Hyperparathyroidism

We are studying whether bisphosphonate treatment before parathyroid surgery can improve bone, kidney, and heart health one year after the procedure. This trial compares the treatment to a placebo to see if there are any benefits.

Primary Hyperparathyroidism1-2 yearsConfirmation phase (III)Monitoring phase (IV)6-10 visitsStandard MedicinesCost ReimbursementEndocrinologyOrthopedics and Traumatology

Clonidine for Preventing Agitation in Young Children After Anesthesia

We are studying whether clonidine can help reduce agitation and pain in children under one year after surgery. The trial also examines its safety and effects on nausea and opioid use.

Postoperative Agitation≤3 monthsEfficacy phase (II)No PlaceboStandard MedicinesOtolaryngologyPediatrics

Lung Cancer: Nivolumab with Ipilimumab and Chemotherapy

We are studying a new way to administer nivolumab alongside ipilimumab and chemotherapy for patients with untreated metastatic or recurrent lung cancer. The trial aims to understand how the body reacts to this combination and its safety.

Non-small cell lung cancer6-12 monthsEfficacy phase (II)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesOncology

Hodgkin Lymphoma: Ruxolitinib with Brentuximab or Pembrolizumab

We are studying the combination of ruxolitinib with either brentuximab or pembrolizumab for patients with relapsed or refractory classical Hodgkin lymphoma. The goal is to see if this combination improves treatment response and safety.

Recurrent or Refractory Classical Hodgkin Lymphoma3-6 monthsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesOncology

Ravulizumab for Pediatric IgA Nephropathy

We are studying how Ravulizumab works in children with Primary Immunoglobulin A Nephropathy. This research may help us understand its effects and safety in younger patients.

Immunoglobulin A Nephropathy6-12 monthsConfirmation phase (III)>20 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesNephrologyPediatrics

Ovarian Cancer: Sentinel Lymph Node Technique Study

We are evaluating a new technique to detect lymph node spread in early-stage ovarian cancer patients. This study aims to see how well it works compared to traditional methods.

Ovarian Cancer>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesGynecology and ObstetricsOncology

Knee Replacement Surgery: Local Anesthetic Comparison

We are studying whether using 20 mL of local anesthetic instead of 10 mL during a nerve block can reduce opioid use and improve pain management after knee surgery.

Postoperative Pain After Knee Surgery≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOrthopedics and TraumatologyOtolaryngology

Ulcerative Colitis: Mirikizumab with Tirzepatide

We are studying whether combining mirikizumab with tirzepatide helps adults with moderately to severely active ulcerative colitis and obesity achieve better remission and weight loss than mirikizumab alone.

Obesity or OverweightUlcerative Colitis1-2 yearsConfirmation phase (III)16-20 visitsStandard MedicinesPartially RemoteEndocrinologyGastroenterology

Crohn’s Disease: Mirikizumab with Tirzepatide

We are studying whether a combination of mirikizumab and tirzepatide helps adults with moderately to severely active Crohn’s disease achieve better remission and weight loss than mirikizumab alone.

Crohn’s DiseaseObesity or Overweight1-2 yearsConfirmation phase (III)16-20 visitsStandard MedicinesCost ReimbursementPartially RemoteEndocrinologyGastroenterology

Cholangiocarcinoma: Ivosidenib Maintenance Therapy

We are studying whether the drug ivosidenib can help patients with mIDH1 cholangiocarcinoma after standard chemotherapy. The trial will also look at its safety and effects on quality of life.

Cholangiocarcinoma Treatment>2 yearsEfficacy phase (II)Confirmation phase (III)16-20 visitsNo PlaceboStandard MedicinesGastroenterologyOncology

Improving Sleep and Mood in Postmenopausal Women: DHEA and Melatonin Study

We are studying whether a combination of DHEA and melatonin can enhance sleep quality and mood in postmenopausal women. This research may help address sleep issues and mood changes related to menopause.

Menopause and Sleep Disorders≤3 monthsConfirmation phase (III)Standard MedicinesGynecology and ObstetricsInternal MedicinePsychiatry

TAILORED-PROM: Personalized Treatment for Preterm Premature Rupture of Membranes

We are studying if a customized antibiotic and steroid therapy can help prolong pregnancy and improve outcomes for mothers and newborns. This approach may reduce unnecessary antibiotic use compared to standard treatments.

Preterm Premature Rupture of Membranes>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesPartially RemoteGynecology and ObstetricsInfectious Diseases

Head and Neck Cancer: New Treatment Approach with Pembrolizumab

We are studying a new sequence of treatments for patients with recurrent head and neck cancer to see if it improves survival compared to standard therapies. We will also evaluate how well patients tolerate the treatments and their quality of life.

Recurrent Head and Neck Squamous Cell Carcinoma>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesOncology

Irritable Bowel Syndrome: Saccharomyces boulardii CNCM I-745

We are studying whether a probiotic can help adults with non-constipated IBS feel better and improve their quality of life compared to a placebo.

Non-constipated Irritable Bowel Syndrome3-6 monthsConfirmation phase (III)≤5 visitsStandard MedicinesCost ReimbursementPartially RemoteGastroenterology

Recovery After Gallbladder Surgery: Esmolol vs. Sufentanil

We are comparing two medications to see which one helps patients recover more comfortably after laparoscopic gallbladder surgery. This study aims to improve patient comfort during the recovery process.

Laparoscopic Gallbladder Removal1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyInternal MedicineOrthopedics and TraumatologyOtolaryngology

Metastatic Colorectal Cancer: RAXO Trial

We are studying how metastatic colorectal cancer behaves and the effectiveness of different treatments in patients. This research aims to improve surgical options and overall patient outcomes.

Advanced Colorectal Cancer>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesOncology

Breast Cancer: Typology-based Coaching with Ribociclib

We are studying whether personalized coaching and education can help patients with HR+ HER2- early breast cancer stay on their ribociclib treatment. This may improve their treatment experience and overall health outcomes.

Hormone Receptor Positive Breast CancerBreast Cancer>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteInternal MedicineOncology

Scabies Treatment Comparison: Permethrin vs. Ivermectin

We are comparing the effectiveness of topical permethrin, oral ivermectin, and their combination for treating scabies. The goal is to find out which treatment works best and is safest for patients.

Scabies≤3 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesDermatologyInfectious Diseases