Search Clinical Trials in the European Union

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Confirmation phase (III)
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201-220 of 1,307 trials

Polycystic Ovary Syndrome: Letrozole vs. Gonadotropins for Insemination

We are studying whether letrozole can be a better option than gonadotropins for achieving pregnancy in women with polycystic ovary syndrome. The trial will also examine miscarriage rates and treatment responses.

Insemination in Patients with Polycystic Ovary Syndrome>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesEndocrinologyGynecology and Obstetrics

Non-Squamous Lung Cancer: Pembrolizumab Dosing Study

We are comparing the usual dose of Pembrolizumab with a lower dose for patients with non-squamous lung cancer. The goal is to see if the lower dose is as effective in maintaining treatment benefits.

Metastatic Non-Squamous Lung Cancer>2 yearsConfirmation phase (III)OncologyPulmonology

Alpha-1 Antitrypsin Deficiency: Fazirsiran Treatment Study

We are investigating the long-term safety of fazirsiran for people with liver disease related to Alpha-1 Antitrypsin Deficiency. The study will also look at how this treatment affects liver health over time.

Alpha-1 Antitrypsin Deficiency3-6 monthsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesHepatologyPulmonology

Metastatic Non-Small Cell Lung Cancer: Pembrolizumab with Sacituzumab Govitecan

We are studying whether combining pembrolizumab with sacituzumab govitecan improves survival and quality of life for patients with metastatic non-small cell lung cancer. This trial compares the combination treatment to pembrolizumab alone.

Metastatic Non-small Cell Lung Cancer>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesCost ReimbursementOncology

Hereditary Angioedema: OCTA-C1-INH Treatment Study

We are studying a new intravenous treatment for people with hereditary angioedema to see if it effectively relieves symptoms during acute attacks. The trial includes adolescents and adults, and also looks at safety and quality of life.

Hereditary Angioedema1-2 yearsConfirmation phase (III)≤5 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementPartially RemoteAllergologyHematology

Melatonin for Chronic Back Pain

We are studying whether melatonin can help reduce pain and improve sleep in people with chronic back pain. This trial compares melatonin to a placebo to see which is more effective.

Chronic Back Pain≤3 monthsConfirmation phase (III)≤5 visitsStandard MedicinesCost ReimbursementInternal MedicineOrthopedics and Traumatology

MK-2870 vs Chemotherapy for Advanced Lung Cancer

We are studying a new treatment, MK-2870, for patients with advanced nonsquamous non-small cell lung cancer who have specific genetic mutations. The goal is to see if it works better than standard chemotherapy options.

Non-small Cell Lung Cancer>2 yearsConfirmation phase (III)Investigational MedicinesOncology

Advanced Non-Small Cell Lung Cancer: Zipalertinib with Chemotherapy

We are studying whether adding zipalertinib to standard chemotherapy helps patients with advanced non-small cell lung cancer who have a specific genetic mutation. This trial compares the effects of the combination treatment to chemotherapy alone.

Non-Small Cell Lung Cancer6-12 monthsConfirmation phase (III)16-20 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteOncologyPulmonology

Cardiogenic Shock: Early Empagliflozin Treatment

We are studying if starting empagliflozin early helps patients with cardiogenic shock improve their heart function and reduce hospital visits. This trial compares the new treatment with standard care to see which is more effective.

Cardiogenic Shock3-6 monthsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteCardiologyInternal Medicine

Pulmonary Arterial Hypertension: Seralutinib Inhalation Study

We are studying whether inhaling seralutinib helps improve exercise capacity in people with pulmonary arterial hypertension. The trial also looks at safety and other health benefits compared to a placebo.

Pulmonary Arterial Hypertension1-2 yearsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementCardiologyPulmonology

Atopic Dermatitis in Children: Tralokinumab Treatment

We are studying whether a new treatment with tralokinumab and topical steroids helps children aged 2 to under 12 and infants aged 6 months to under 2 manage moderate-to-severe atopic dermatitis better than a placebo. The trial also looks at how this treatment affects daily life and skin health.

Atopic Dermatitis1-2 yearsEfficacy phase (II)Confirmation phase (III)Post-Trial Drug AccessStandard MedicinesCost ReimbursementPartially RemoteAllergologyDermatology

Efepoetin Alfa for Anemia in Chronic Kidney Disease on Dialysis

We are studying whether efepoetin alfa can effectively manage anemia in patients with chronic kidney disease on dialysis, compared to another treatment. This trial will also assess safety and quality of life for participants.

Anemia of Chronic Disease1-2 yearsConfirmation phase (III)>20 visitsNo PlaceboInvestigational MedicinesPartially RemoteHematologyNephrology

Breast Cancer-Related Lymphedema: Topical Tacrolimus Study

We are investigating whether a topical ointment can reduce swelling in patients with breast cancer-related lymphedema. This study compares the ointment to a placebo to see if it improves symptoms and quality of life.

Lymphedema1-2 yearsConfirmation phase (III)≤5 visitsPost-Trial Drug AccessStandard MedicinesPartially RemoteInternal MedicineOncology

Community-Acquired Pneumonia: Amoxicillin vs. Amoxicillin/Clavulanate

We are studying whether amoxicillin alone is as effective as amoxicillin/clavulanate for treating pneumonia in hospitalized patients aged 65 and older. This research may help determine the best antibiotic treatment for older adults.

Community-Acquired Pneumonia in Elderly Patients>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesInfectious DiseasesPulmonology

Systemic Lupus Erythematosus: Upadacitinib Study

We are investigating whether the oral medication upadacitinib can improve symptoms in adults with moderate to severe systemic lupus erythematosus. The study will also monitor its safety over time compared to a placebo.

Systemic Lupus Erythematosus1-2 yearsConfirmation phase (III)>20 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementRheumatology

Hidradenitis Suppurativa: Upadacitinib Study

We are testing Upadacitinib in adults and adolescents with moderate to severe Hidradenitis Suppurativa who haven't responded to other treatments. The goal is to see if it is more effective and safe than a placebo.

Hidradenitis Suppurativa>2 yearsConfirmation phase (III)16-20 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteDermatology

Chronic Cutaneous Lupus Erythematosus: Anifrolumab Study

We are investigating whether anifrolumab can improve skin symptoms in adults with chronic cutaneous lupus erythematosus who haven't responded to other treatments. The study will compare its effects to a placebo over 24 weeks.

Cutaneous Lupus Erythematosus1-2 yearsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementPartially RemoteDermatologyRheumatology

Aspirin for Preeclampsia Prevention in Twin Pregnancies

We are studying whether low-dose aspirin can help prevent preeclampsia in women expecting twins. This research aims to improve outcomes for mothers and their babies.

Preeclampsia6-12 monthsConfirmation phase (III)≤5 visitsInvestigational MedicinesGynecology and ObstetricsInternal Medicine

Advanced Breast Cancer: Lasofoxifene and Abemaciclib vs. Fulvestrant and Abemaciclib

We are studying two treatment combinations for men and women with advanced breast cancer and an ESR1 mutation. The goal is to see which combination helps patients live longer without disease progression.

Metastatic Breast Cancer1-2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementOncology

Elderly Surgery: Comparing Anesthesia Methods

We are studying how desflurane, sevoflurane, and propofol affect the risk of delirium and cognitive function in elderly patients after major abdominal surgery. This research aims to improve recovery outcomes for older adults undergoing surgery.

Postoperative Delirium>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesPartially Remote