Search Clinical Trials in the European Union

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221-240 of 240 trials

Insomnia in Adolescents: Melatonin vs. Quetiapine

We are studying whether melatonin or low-dose quetiapine can improve sleep in adolescents with psychiatric disorders and insomnia. We’ll also look at how these treatments affect overall well-being and daily functioning.

Psychiatric Disorders and Insomnia≤3 monthsEfficacy phase (II)Confirmation phase (III)6-10 visitsStandard MedicinesCost ReimbursementPartially RemotePsychiatry

Postoperative Pain Management: Fentanyl Nasal Spray

We are studying a fentanyl nasal spray for pain relief after orthopedic surgery, comparing it to a placebo and standard morphine treatment. The goal is to assess its effectiveness and side effects in managing pain.

Postoperative Pain Relief≤3 monthsConfirmation phase (III)Investigational MedicinesInternal MedicineOrthopedics and TraumatologyPsychiatry

Cholesterol Management: Fixed Dose Combination Study

We are evaluating a new combination pill of bempedoic acid, ezetimibe, and atorvastatin for patients managing high cholesterol. The goal is to see if this combination works as well as taking each medication separately.

Healthy Participants≤3 monthsSafety phase (I)CardiologyInternal Medicine

Cystic Fibrosis: Nebulized Bacteriophage Treatment

We are studying a new nebulized treatment for adults with cystic fibrosis and chronic Pseudomonas lung infection. The goal is to see if it helps reduce the infection and improve lung function and quality of life.

Cystic Fibrosis≤3 monthsEfficacy phase (II)Investigational MedicinesCost ReimbursementPartially RemoteInternal MedicinePulmonology

Psoriasis in Children: IDP-122 Lotion Study

We are testing a new lotion for children with moderate to severe plaque psoriasis to see how safe it is and how well it is absorbed into the body. This study will help us understand its effects on children's hormonal systems.

Plaque Psoriasis≤3 monthsEfficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesDermatologyEndocrinology

Clonidine for Preventing Agitation in Young Children After Anesthesia

We are studying whether clonidine can help reduce agitation and pain in children under one year after surgery. The trial also examines its safety and effects on nausea and opioid use.

Postoperative Agitation≤3 monthsEfficacy phase (II)No PlaceboStandard MedicinesOtolaryngologyPediatrics

Bipolar-I Disorder: KarXT Treatment Study

We are testing a new treatment called KarXT for people experiencing manic episodes in Bipolar-I Disorder. The study aims to see if it helps reduce mania symptoms better than a placebo.

Bipolar Disorder with Mania≤3 monthsConfirmation phase (III)Post-Trial Drug AccessInvestigational MedicinesPsychiatry

Knee Replacement Surgery: Local Anesthetic Comparison

We are studying whether using 20 mL of local anesthetic instead of 10 mL during a nerve block can reduce opioid use and improve pain management after knee surgery.

Postoperative Pain After Knee Surgery≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOrthopedics and TraumatologyOtolaryngology

Improving Sleep and Mood in Postmenopausal Women: DHEA and Melatonin Study

We are studying whether a combination of DHEA and melatonin can enhance sleep quality and mood in postmenopausal women. This research may help address sleep issues and mood changes related to menopause.

Menopause and Sleep Disorders≤3 monthsConfirmation phase (III)Standard MedicinesGynecology and ObstetricsInternal MedicinePsychiatry

Chronic Cluster Headache: Low-Dose LSD Study

We are investigating whether a low dose of LSD can help reduce the frequency and severity of chronic cluster headaches. This study will assess both its effectiveness and safety compared to a placebo.

Chronic Cluster Headache≤3 monthsEfficacy phase (II)6-10 visitsInvestigational MedicinesCost ReimbursementPartially RemoteNeurology

Milsaperidone for Major Depressive Disorder

We are studying whether adding milsaperidone to current antidepressant therapy can improve symptoms in patients with Major Depressive Disorder. The trial also looks at the safety of this new treatment compared to a placebo.

Major Depressive Disorder≤3 monthsConfirmation phase (III)Post-Trial Drug AccessInvestigational MedicinesPsychiatry

Scabies Treatment Comparison: Permethrin vs. Ivermectin

We are comparing the effectiveness of topical permethrin, oral ivermectin, and their combination for treating scabies. The goal is to find out which treatment works best and is safest for patients.

Scabies≤3 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesDermatologyInfectious Diseases

Healthy Volunteers Needed: Itraconazole and BI 3031185 Study

We are testing how itraconazole affects the levels of BI 3031185 in the blood of healthy participants. This study aims to improve our understanding of drug interactions.

Healthy Volunteers≤3 monthsSafety phase (I)DermatologyInternal MedicineOphthalmologyOtolaryngologyPediatricsPsychiatry

Rapamycin Cream for Port Wine Stains

We are studying whether two strengths of rapamycin cream can improve the appearance of port wine stains in individuals after laser therapy. Participants will compare the effects of the cream to a placebo over several weeks.

Port Wine Stain≤3 monthsEfficacy phase (II)≤5 visitsStandard MedicinesDermatology

Postoperative Pain Relief: High Dose Dexamethasone for Lung Surgery

We are studying whether a higher dose of Dexamethasone can reduce pain after video-assisted thoracoscopic surgery in patients who typically experience high pain. This trial compares a high dose to a standard lower dose to find the best pain management approach.

Lung Cancer≤3 monthsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesInternal MedicineOrthopedics and TraumatologyOtolaryngologyPulmonology

Atrial Fibrillation: Amiodarone Administration Study

We are comparing intravenous and enteral amiodarone in critically ill patients with new-onset atrial fibrillation. The goal is to see which method is more effective in restoring normal heart rhythm and improving overall health.

Atrial Fibrillation with Rapid Ventricular Response≤3 monthsMonitoring phase (IV)No PlaceboInvestigational MedicinesCardiologyInternal Medicine

Lactose Intolerance Diagnosis: LacTEST for Children

We are studying the LacTEST to see if it accurately diagnoses lactose intolerance in children aged 5 to 11. The trial will also check the test's safety and whether a shorter urine collection time is effective.

Lactose Intolerance≤3 monthsMonitoring phase (IV)≤5 visitsNo PlaceboInvestigational MedicinesPartially RemoteGastroenterologyPediatrics

CIT-013 for Inflammatory Mediated Immune Diseases

We are studying how a new treatment, CIT-013, spreads in the body of patients with inflammatory mediated immune diseases. We also want to learn about its safety and how the body handles it.

Inflammatory Mediated Immune Diseases≤3 monthsEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesInfectious DiseasesRheumatology

Influenza Vaccine Study: Seqirus H5N8

We are investigating how well the Seqirus H5N8 influenza vaccine works in adults who have been previously vaccinated and those who have never received an H5 vaccine. The study aims to assess immune responses and safety in both groups.

H5N1 Influenza Immunization≤3 monthsMonitoring phase (IV)≤5 visitsNo PlaceboInvestigational MedicinesInfectious Diseases

COVID-19 Vaccine Study: BIMERVAX® LP.8.1

We are evaluating the safety and immune response of the BIMERVAX® LP.8.1 vaccine against COVID-19 variants. This study aims to understand how well it works in generating antibodies to fight the virus.

COVID-19≤3 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesInfectious Diseases