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1-20 of 240 trials

Diabetic Foot Infections: Contezolid Treatment Study

We are studying a new treatment called contezolid for adults with moderate to severe diabetic foot infections. The goal is to see if it is safer and more effective than the current standard treatment, linezolid.

Diabetic Foot Infection≤3 monthsConfirmation phase (III)6-10 visitsInvestigational MedicinesCost ReimbursementPartially RemoteEndocrinologyInfectious Diseases

Etripamil Nasal Spray for Pediatric Heart Condition

We are studying whether a nasal spray can help stop episodes of a fast heart rate in children aged 6 to 17. The trial also looks at how safe the spray is for these young patients.

Paroxysmal Supraventricular Tachycardia≤3 monthsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCardiologyPediatrics

Chronic Kidney Disease: Amiloride Treatment Study

We are investigating whether the diuretic amiloride can help protect kidney function in people with chronic kidney disease. The study looks at its effects on kidney health and inflammation.

Chronic Kidney Disease≤3 monthsEfficacy phase (II)6-10 visitsStandard MedicinesCost ReimbursementPartially RemoteInternal MedicineNephrology

Post-Traumatic Stress Disorder: Testing New Therapy

We are studying a new therapy called reconsolidation therapy for people with severe PTSD. This trial compares it to standard treatment and looks at whether adding propranolol can improve outcomes.

Post-Traumatic Stress Disorder≤3 monthsEfficacy phase (II)No PlaceboStandard MedicinesPsychiatry

Esophageal Cancer Treatment: The NEEDS Trial

We are comparing two treatment methods for operable esophageal squamous cell carcinoma to see which may help patients survive longer. The study also examines quality of life and other health impacts during and after treatment.

Locally Advanced Esophageal Squamous Cell Carcinoma≤3 monthsConfirmation phase (III)No PlaceboInvestigational MedicinesPartially RemoteOncology

Semaglutide for Acute Ischemic Stroke

We are studying whether a new injection of semaglutide is safe and effective for non-diabetic patients right after an ischemic stroke. This trial aims to improve treatment options during this critical time.

Ischemic Stroke≤3 monthsEfficacy phase (II)No PlaceboInvestigational MedicinesCardiologyNeurology

Preventing Second Cancers: Dostarlimab Study

We are studying whether dostarlimab can help prevent second primary cancers in patients who have been cured of their first cancer. This trial will also look at the safety of the treatment.

Cancer Survivor at Risk for Second Cancer≤3 monthsEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesOncology

Skin Candidiasis: Mecloderm® Ointment Study

We are comparing a new ointment with clotrimazole and betamethasone to an existing treatment and a placebo for patients with moderate to severe skin infections caused by yeast. The study aims to assess how well these treatments work and their safety.

Skin and Nail Candidiasis≤3 monthsConfirmation phase (III)≤5 visitsStandard MedicinesDermatologyInfectious Diseases

Advanced Solid Tumors: Sacituzumab Govitecan Study

We are exploring a new medication for patients with advanced or metastatic solid tumors who also have moderate liver impairment. The goal is to find a safe starting dose for this treatment.

Solid Tumors≤3 monthsSafety phase (I)HepatologyOncology

Serious Bacterial Infections in Children: Aztreonam-Avibactam Study

We are investigating a new treatment for serious gram-negative bacterial infections in children aged 9 months to under 18 years. The study compares this treatment to the best available therapy to assess safety and effectiveness.

Hospital-Acquired PneumoniaVentilator-Associated PneumoniaComplicated Gram-Negative Bacterial Infections≤3 monthsEfficacy phase (II)16-20 visitsNo PlaceboInvestigational MedicinesPartially RemoteInfectious DiseasesPediatrics

Major Depressive Disorder: Minocycline vs. Celecoxib

We are studying whether minocycline or celecoxib can help patients with Major Depressive Disorder who haven't responded to previous treatments. The trial will compare how well these medications work and how patients respond to them.

Major Depressive Disorder≤3 monthsConfirmation phase (III)6-10 visitsStandard MedicinesCost ReimbursementPsychiatry

Metformin Transfer in Breast Milk: A Study for Lactating Women

We are investigating how metformin, used for Type 2 Diabetes, transfers into breast milk and affects breastfeeding infants. This research aims to ensure the safety of breastfeeding while on this medication.

Type 2 Diabetes and Gestational Diabetes≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesEndocrinologyPediatrics

COVID-19 Treatment: LTX-109 Nasal Spray Study

We are testing a new nasal spray for people with COVID-19 or similar symptoms to see if it helps them recover faster and clear the virus. The study will also monitor safety and overall wellbeing during treatment.

Respiratory Tract InfectionCOVID-19COVID-like Illness≤3 monthsEfficacy phase (II)Confirmation phase (III)Investigational MedicinesPartially RemoteInfectious DiseasesPulmonology

Generalized Periodontitis: Valaciclovir Treatment Study

We are investigating whether the antiviral drug Valaciclovir can improve treatment outcomes for people with advanced generalized periodontitis. This study compares its effects to standard treatments and a placebo.

Generalized Periodontitis≤3 monthsConfirmation phase (III)Investigational MedicinesInfectious DiseasesOtolaryngology

Osteoarthritis: Walking Rehabilitation with Anti-Inflammatory Treatment

We are exploring how a specific anti-inflammatory medication can support a walking rehabilitation program for people with hip or knee osteoarthritis. The goal is to see if this combination improves walking ability and overall comfort.

Osteoarthritis of the Hip or Knee≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineRheumatology

Nuwiq for Women and Girls with Hemophilia A Needing Surgery

We are studying how well Nuwiq works to control bleeding during major surgery for women and girls with hemophilia A. The trial will also look at its safety and effects on blood product use.

Haemophilia A≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesHematologyInternal Medicine

THC Oil for Chronic Neuropathic Pain

We are studying the effects of THC 2% oil on pain relief in patients with chronic neuropathic pain. The trial will also explore how different patient traits may influence the treatment's effectiveness and safety.

Neuropathic Pain≤3 monthsEfficacy phase (II)Investigational MedicinesPartially RemoteInternal MedicineNeurology

Stage III Lung Cancer: MK-7684A Treatment Study

We are studying a new treatment combining MK-7684A with radiation and chemotherapy for patients with unresectable Stage III lung cancer. This trial compares it to standard treatment followed by Durvalumab.

Non-small cell lung cancer≤3 monthsConfirmation phase (III)Monitoring phase (IV)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementInternal MedicineOncology

TAK-330 for Reversing Blood Thinner Effects in Urgent Surgery

We are studying whether TAK-330 can effectively reverse the effects of certain blood thinners in patients needing urgent surgery. This trial compares TAK-330 to the standard treatment to see which works better.

Patients on Factor Xa Inhibitors Needing Urgent Intervention≤3 monthsConfirmation phase (III)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteHematologyInternal Medicine

Colitis from Cancer Treatment: The iCaD Study

We are comparing a new treatment combining infliximab with corticosteroids for severe colitis caused by immune checkpoint inhibitors. This study aims to see if this combination is more effective than corticosteroids alone.

Immune Checkpoint Inhibitor Related Colitis≤3 monthsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesGastroenterologyOncology