Search Clinical Trials in the European Union

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301-320 of 552 trials

Oxygen Management During Anesthesia: The LOWOX Trial

We are studying whether a tailored approach to oxygen levels during anesthesia improves recovery and oxygen levels after surgery compared to standard fixed oxygen use. This trial involves patients undergoing various surgical procedures.

Surgery under General Anesthesia3-6 monthsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOtolaryngology

Botulinum Toxin for Spastic Equinovarus in Stroke Patients

We are exploring how a treatment with botulinum toxin type A affects muscle and nerve properties in people who have had their first stroke. This study aims to gather insights that could improve future treatments for spastic equinovarus.

Spastic Equinovarus in Stroke Patients3-6 monthsConfirmation phase (III)Monitoring phase (IV)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesNeurologyOrthopedics and Traumatology

Surgery Fluid Study: Albumin vs. Ringer's Solution

We are comparing two fluids to see which one better supports blood volume and circulation during laparoscopic surgery. This research may help improve patient care in surgical settings.

Fluid Therapy in Laparoscopic Surgery>2 yearsMonitoring phase (IV)No PlaceboInvestigational MedicinesInternal MedicineOtolaryngology

Multiple Sclerosis: Personalized Ocrelizumab Treatment

We are studying whether a tailored dosing of ocrelizumab is as effective as the standard treatment in managing relapsing remitting multiple sclerosis. This trial aims to improve treatment personalization for better disease control.

Multiple Sclerosis>2 yearsConfirmation phase (III)Monitoring phase (IV)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteNeurology

Axial Spondyloarthritis: NSAIDs vs. Biosimilar TNF Blockers

We are comparing the effectiveness of high-dose NSAIDs and a biosimilar TNF blocker for patients with axial spondyloarthritis who haven't responded to NSAIDs. The study will also look at side effects and inflammation levels.

Axial Spondyloarthritis3-6 monthsMonitoring phase (IV)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesInternal MedicineRheumatology

Alternative Antibiotics for Resistant UTIs

We are testing new oral antibiotics for patients with febrile urinary tract infections caused by resistant bacteria. The goal is to see if these alternatives are as safe as current treatments.

Urinary Tract Infection (UTI) from Resistant Bacteria>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesPartially RemoteInfectious DiseasesUrology

Crohn's and Colitis: Stopping Anti-TNF Treatment

We are studying if specific markers can help identify patients who can safely stop their anti-TNF treatment while in remission. This may help tailor treatment plans for better health outcomes.

Ulcerative ColitisCrohn's Disease>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteGastroenterologyInternal Medicine

Acute Pyelonephritis: Short vs. Long Antibiotic Treatment

We are studying whether a 7-day antibiotic treatment is as effective as a 14-day treatment for kidney transplant recipients with acute pyelonephritis. This research aims to improve treatment options and patient safety.

Kidney Infection (Pyelonephritis)Kidney Transplant Recipients>2 yearsMonitoring phase (IV)Standard MedicinesInfectious DiseasesNephrologyUrology

Rimegepant for Migraine: Effects on Obesity

We are studying how rimegepant affects migraine-related reactions in lean and obese individuals. The goal is to understand the relationship between body composition and migraine responses.

ObesityMigraine6-12 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementEndocrinologyNeurology

Skin Cancer Treatment: The BLESS Trial

We are investigating whether reducing the dose of bleomycin in electrochemotherapy can still effectively treat skin cancers. This study aims to see if patients can benefit from less medication while achieving similar tumor response.

Skin Cancer>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesDermatologyOncology

Dupilumab for Uncontrolled Moderate to Severe Asthma

We are studying whether dupilumab can help prevent lung function decline in adults with uncontrolled moderate to severe asthma. This trial will compare its effects to a placebo over time.

AsthmaMonitoring phase (IV)6-10 visitsInvestigational MedicinesCost ReimbursementAllergologyPulmonology

Cardiovascular Disease Prevention: Personalized Statin Therapy

We are studying whether statin treatment guided by genetic risk can lower heart disease events in individuals at high risk. The trial will also look at how well patients accept this personalized approach and its effects on their health.

High Genetic Risk for Coronary Artery Disease1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCost ReimbursementPartially RemoteCardiologyInternal Medicine

Omalizumab Withdrawal in Severe Allergic Asthma

We are studying whether stopping Omalizumab after long-term treatment is as effective as continuing it for patients with well-controlled severe allergic asthma. This trial aims to assess asthma control and quality of life over time.

Allergic Asthma1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesAllergologyPulmonology

Cortisone Treatment for Children with Facial Nerve Palsy

We are studying whether cortisone can help children with acute facial nerve paralysis recover better than a placebo. The trial will also look at safety and how the condition affects daily life.

Facial Nerve Palsy (Bell's Palsy)>2 yearsMonitoring phase (IV)Standard MedicinesNeurologyPediatrics

Oxytocin Treatment for Autism in Children

We are studying whether multiple doses of oxytocin can improve social symptoms in children with autism and intellectual disability. The trial also looks at other behavioral changes and stress-related measurements.

Autism Spectrum Disorder6-12 monthsConfirmation phase (III)Monitoring phase (IV)≤5 visitsStandard MedicinesCost ReimbursementPartially RemotePediatricsPsychiatry

Cancer Treatments: Impact on Speech and Quality of Life

We are studying how different cancer treatments affect speech understanding in noise and overall quality of life for patients. This research may help us understand the cognitive effects of these treatments over time.

Bladder CancerTesticular SeminomaHead and Neck Cancer≤3 monthsMonitoring phase (IV)No PlaceboInvestigational MedicinesOncologyPsychiatry

Acute Bacterial Prostatitis: Fosfomycin vs. Cefixime

We are comparing two oral antibiotics to see which one better resolves urinary symptoms in men with acute bacterial prostatitis. The study will also look at any side effects and the effectiveness of the treatments over time.

Acute Bacterial Prostatitis3-6 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesInfectious DiseasesUrology

Polymyalgia Rheumatica: Rituximab Study

We are investigating whether rituximab can help reduce the need for corticosteroids in people with relapsing polymyalgia rheumatica. This study compares rituximab to a placebo to assess its effectiveness.

Polymyalgia Rheumatica1-2 yearsMonitoring phase (IV)6-10 visitsStandard MedicinesCost ReimbursementPartially RemoteGastroenterologyRheumatology

Hernia Repair: Comparing Pain Relief Techniques

We are studying whether giving a specific pain relief injection before or after hernia surgery helps reduce chronic pain and the need for pain medications. This trial is for patients undergoing open inguinal hernia mesh repair.

Chronic Pain After Hernia Surgery1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOrthopedics and Traumatology

OM85 for Preventing Respiratory Infections in Elderly Patients

We are studying whether the drug OM85 can help reduce respiratory infections in elderly individuals living in healthcare residences. This trial will also look at hospital visits and antibiotic use related to these infections.

Recurrent Respiratory Tract InfectionsMonitoring phase (IV)Standard MedicinesInternal MedicinePulmonology