Search Clinical Trials in the European Union

>2 years
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321-340 of 1,743 trials

Colorectal Liver Metastases: IP-001 Immuno-Adjuvant Study

We are exploring a new treatment to see if it improves outcomes for patients with colorectal liver metastases after microwave ablation or electroporation. The study will help us understand the best dose and immune response.

Colorectal Liver Metastases>2 yearsSafety phase (I)Efficacy phase (II)GastroenterologyHepatologyInternal MedicineOncology

Carotid Stenosis: Ficolin-2 and Inflammation Study

We are investigating how levels of ficolin-2 relate to inflammation in the carotid arteries and brain in patients who have had a stroke or transient ischemic attack. This research may help us understand the underlying causes of these conditions better.

Stroke or Transient Ischemic Attack (TIA)>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementCardiologyInternal MedicineNeurology

Hereditary Haemochromatosis: NNC0614-0001 Study

We are evaluating the effects of a new treatment in healthy adults and individuals with hereditary haemochromatosis type 1. This research aims to understand how the treatment works in these groups.

Hereditary Hemochromatosis>2 yearsSafety phase (I)HematologyInternal Medicine

Hypotension Treatment: Early Vasopressor Therapy

We are studying whether starting vasopressor therapy early helps hypotensive patients in the emergency department recover faster than standard fluid therapy. This may reduce the need for intensive care admission.

Low Blood Pressure (Hypotension)Shock>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesCardiologyInfectious DiseasesInternal MedicinePulmonology

COVID-19 Vaccine Booster Study: CD40.RBDv

We are testing a new bivalent COVID-19 vaccine to see if it safely boosts immunity in volunteers. This study will help us understand its effectiveness compared to existing vaccines.

COVID-19>2 yearsSafety phase (I)Infectious Diseases

Advanced Non-Small Cell Lung Cancer: THIO with Cemiplimab

We are studying the safety and effectiveness of a new treatment combining THIO and cemiplimab for people with advanced non-small cell lung cancer. This trial aims to find out if this combination works better than THIO alone for patients who have already been treated.

Non-Small Cell Lung Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesCost ReimbursementPartially RemoteOncology

Focal Segmental Glomerulosclerosis: DMX-200 Treatment Study

We are studying the effects of DMX-200 on kidney function in patients with focal segmental glomerulosclerosis who are taking an angiotensin II receptor blocker. This trial will help us understand its safety and effectiveness compared to standard treatments.

Focal Segmental Glomerulosclerosis>2 yearsConfirmation phase (III)Post-Trial Drug AccessInvestigational MedicinesPartially RemoteNephrology

Advanced Solid Tumors: IPH5301 Treatment Study

We are exploring a new treatment called IPH5301, both alone and with chemotherapy and trastuzumab, for patients with advanced solid tumors. This study aims to understand how well it works and its safety in humans.

Advanced and Metastatic Cancer>2 yearsSafety phase (I)Oncology

Chemotherapy-Induced Peripheral Neuropathy: Capsaicin Patch vs. Duloxetine

We are studying whether a capsaicin patch can reduce nerve pain better than duloxetine in patients with chemotherapy-induced peripheral neuropathy. The trial also looks at safety and overall quality of life improvements.

Chemotherapy Induced Peripheral Neuropathy>2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesNeurologyOncology

Chronic Coccygodynia: Capsaicin 8% Patches

We are testing the effectiveness of capsaicin patches for people suffering from chronic tailbone pain. This study aims to see if these patches can provide better pain relief than a placebo.

Neuropathic PainChronic Coccygodynia>2 yearsConfirmation phase (III)Neurology

Richter Transformation: Testing New Combination Therapy

We are studying a combination of three medications for patients with Richter transformation of chronic lymphocytic leukemia. The goal is to evaluate how well this treatment works and its safety.

Chronic Lymphocytic Leukaemia Variants>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesHematologyOncology

Choroidal Melanoma: Belzupacap Sarotalocan Treatment

We are studying a new treatment for people with primary indeterminate lesions or small choroidal melanoma. The goal is to see if it is more effective and safe compared to a placebo.

Choroidal Melanoma>2 yearsConfirmation phase (III)>20 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementOncologyOphthalmology

Hydroxychloroquine for Pregnancy Outcomes in Women with Antiphospholipid Antibodies

We are studying whether hydroxychloroquine can improve pregnancy outcomes for women with antiphospholipid antibodies. This research aims to help understand its potential benefits during pregnancy.

Antiphospholipid Antibodies>2 yearsConfirmation phase (III)6-10 visitsStandard MedicinesGynecology and ObstetricsInternal Medicine

Multiple Myeloma: ABBV-383 Treatment Study

We are evaluating the safety and optimal dosing of ABBV-383 for individuals with relapsed or refractory multiple myeloma. This study aims to improve treatment options for this challenging condition.

Relapsed or Refractory Multiple Myeloma>2 yearsSafety phase (I)Oncology

Post-Stroke Pain: Understanding Nerve Roles

We are investigating how peripheral nerves influence pain in individuals who have had a stroke. This research may help develop better pain management strategies for stroke survivors.

Central Neuropathic Pain After Stroke>2 yearsConfirmation phase (III)Neurology

Prostate Cancer: Estradiol and Exercise Study

We are exploring whether transdermal estradiol and resistance training can help reduce side effects like sexual dysfunction in men undergoing androgen deprivation therapy for prostate cancer. The study also looks at safety and quality of life improvements.

Prostate Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesEndocrinologyUrology

Advanced Solid Tumors: RO7502175 Treatment Study

We are evaluating a new treatment for patients with locally advanced or metastatic solid tumors. The study looks at its safety and effectiveness alone and with another cancer therapy.

Locally Advanced or Metastatic Solid Tumors>2 yearsSafety phase (I)Oncology

Atopic Dermatitis in Children: Upadacitinib vs. Dupilumab

We are studying whether upadacitinib is as safe and effective as dupilumab for children aged 2 to under 12 with moderate to severe atopic dermatitis. This trial aims to find better treatment options for young patients.

Atopic Dermatitis>2 yearsConfirmation phase (III)>20 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteAllergologyDermatologyPediatrics

Myelofibrosis: Navtemadlin with Ruxolitinib

We are studying whether adding navtemadlin to ruxolitinib helps patients with myelofibrosis who aren't responding well to their current treatment. The trial looks at changes in spleen size and symptoms, along with safety and survival.

MyelofibrosisPrimary MyelofibrosisSecondary Myelofibrosis>2 yearsConfirmation phase (III)Post-Trial Drug AccessInvestigational MedicinesCost ReimbursementHematologyOncology

Insomnia in Psychiatric Patients: Melatonin vs. Quetiapine

We are studying whether melatonin or low-dose quetiapine can improve sleep and overall well-being in patients with psychiatric disorders and chronic insomnia. This trial compares these treatments to a placebo to find the most effective option.

Psychiatric Disorders and Insomnia>2 yearsEfficacy phase (II)Confirmation phase (III)Standard MedicinesPsychiatry