Search Clinical Trials in the European Union

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341-360 of 552 trials

Tacrolimus and Blood Sugar Control in Dialysis Patients

We are studying how tacrolimus affects blood sugar levels in patients on hemodialysis waiting for a kidney transplant. This research may help improve diabetes management in these patients.

Hemodialysis>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesEndocrinologyNephrology

Heart Failure: Vericiguat Study

We are studying the effects of vericiguat in patients with heart failure and reduced ejection fraction. The goal is to see if it can lower heart failure markers compared to a placebo.

Heart Failure with Reduced Ejection Fraction (HFrEF)3-6 monthsMonitoring phase (IV)6-10 visitsStandard MedicinesCost ReimbursementPartially RemoteCardiologyInternal Medicine

Atrial Fibrillation: Amiodarone Dose Comparison

We are studying whether a standard or reduced dose of amiodarone is more effective in keeping a normal heart rhythm after cardioversion in patients with persistent atrial fibrillation. We will also assess any side effects and how genetics may affect treatment.

Persistent Atrial Fibrillation>2 yearsMonitoring phase (IV)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCardiologyInternal Medicine

Hemorrhoidal Disease: RAFAELO® Procedure with Pain Management

We are studying whether adding perianal infiltration during the RAFAELO® procedure helps reduce pain after treatment for hemorrhoids. This trial aims to improve comfort for patients undergoing this procedure.

Hemorrhoids>2 yearsConfirmation phase (III)Monitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesGastroenterologyInternal Medicine

Metycor Study for Autonomous Cortisol Secretion

We are testing a new treatment to see if it improves blood pressure, glucose levels, and overall health in patients with autonomous cortisol secretion. The study also looks at effects on weight, bone health, and quality of life.

Mild Autonomous Cortisol Secretion6-12 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteCardiologyEndocrinologyInternal Medicine

Diabetes and Bone Health: Alendronate Study

We are investigating how the medication Alendronate impacts bone and blood sugar markers in individuals with type 1 and type 2 diabetes. This study aims to compare the effects between the two types of diabetes and different assessment methods.

Diabetes and Bone Health IssuesMonitoring phase (IV)Standard MedicinesDiabetologyEndocrinologyRheumatology

EBV Infection: Testing 2LEBV® and 2LXFS® for Fatigue

We are studying whether two new treatments can help reduce fatigue in patients with an EBV infection compared to a placebo. The trial also looks at other symptoms and safety.

Epstein-Barr Virus Infection>2 yearsMonitoring phase (IV)≤5 visitsStandard MedicinesInfectious Diseases

Severe Functional Disorders: Duloxetine and Patient Education

We are studying the effects of patient education and duloxetine on individuals with severe functional disorders. This research aims to explore how these factors may influence symptoms and inflammation.

Functional Somatic Disorder3-6 monthsMonitoring phase (IV)Investigational MedicinesInternal MedicineNeurologyPsychiatry

Cystectomy: Targeted Antibiotic Prophylaxis Study

We are testing whether a personalized antibiotic treatment can help reduce hospital readmissions due to infections after bladder surgery. This study compares it to the standard antibiotic approach used during stent removal.

Bacterial Infection3-6 monthsMonitoring phase (IV)No PlaceboInvestigational MedicinesInfectious DiseasesUrology

Rheumatoid Arthritis: Adalimumab Tapering Study

We are investigating the lowest effective dose of adalimumab for patients with rheumatoid arthritis in remission. The study also looks at how well patients tolerate the treatment and the development of antibodies.

Rheumatoid Arthritis1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineRheumatology

Idiopathic Retroperitoneal Fibrosis: Early Steroid Discontinuation Study

We are investigating whether stopping steroid treatment early in patients with idiopathic retroperitoneal fibrosis affects relapse rates. This study aims to improve treatment strategies for managing this condition.

Idiopathic Retroperitoneal Fibrosis>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementInternal MedicineRheumatology

Neovascular AMD: Faricimab Treatment Study

We are exploring whether two initial doses of faricimab can help keep neovascular AMD inactive in treatment-naive patients. The study also looks at factors that may predict disease activity and recurrence.

Age-related Macular Degeneration>2 yearsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesOphthalmology

Heart Health: Apixaban vs. Warfarin Study

We are comparing two medications to see which is more effective in resolving blood clots in patients with left ventricular thrombus after a heart attack. We're also looking at safety and bleeding risks associated with each treatment.

Acute Myocardial InfarctionLeft Ventricular Thrombosis3-6 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteCardiologyInternal Medicine

BCG Vaccination: Understanding Immune Response

We are studying how pre-vaccination immune status affects the response to the BCG vaccine. This research may help improve vaccination strategies by identifying key immune factors.

Healthy Participants>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesCost ReimbursementInfectious Diseases

Wart Treatment: 2LVERU® JUNIOR and 2LVERU®

We are studying whether two new treatments can help people with warts get rid of them more effectively than a placebo. The trial will also look at pain levels and safety during treatment.

Warts>2 yearsConfirmation phase (III)Monitoring phase (IV)Standard MedicinesDermatologyInfectious Diseases

Severe Vitamin D Deficiency: New Treatment Study

We are investigating a new treatment for people with severe vitamin D deficiency to see if it effectively raises vitamin D levels compared to another option. The study will also look at safety and patient satisfaction.

Severe Vitamin D Deficiency≤3 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesEndocrinologyInternal Medicine

Multiple Sclerosis: Ocrelizumab Serum Monitoring

We are studying how blood levels of ocrelizumab affect treatment outcomes in people with relapsing-remitting and primary progressive multiple sclerosis. This research may help personalize therapy and improve patient care.

Multiple Sclerosis1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineNeurology

Anemia Treatment: Intravenous Iron for Surgery

We are studying whether intravenous iron can help patients with anemia undergoing surgery for lower limb artery disease. The aim is to see if it reduces the need for blood transfusions and improves recovery.

AnemiaMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyHematologyInternal Medicine

Oxygen Support Methods for High-Risk Patients

We are comparing non-invasive ventilation and high flow oxygen therapy for patients at high risk of needing reintubation. The goal is to see which method better helps patients recover and reduces complications.

Weaning Failure>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicinePulmonology

Reducing Anxiety in Children: Multimedia vs. Midazolam

We are studying whether using an iPad can help reduce anxiety in young children before surgery, compared to traditional medication. This trial focuses on children aged 1 to 8 years undergoing day-care procedures.

Perioperative Anxiety in Children6-12 monthsMonitoring phase (IV)Standard MedicinesCost ReimbursementInternal MedicineOtolaryngologyPediatricsPsychiatry