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3721-3740 of 3,900 trials

Bipolar-I Disorder: Long-term Safety of KarXT

We are studying the long-term safety and tolerability of KarXT for people experiencing manic episodes in Bipolar-I Disorder. This trial aims to ensure that the treatment is safe for those affected.

Mania and Bipolar DisorderConfirmation phase (III)16-20 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementPsychiatry

Head and Neck Cancer: New Treatment Approach with Pembrolizumab

We are studying a new sequence of treatments for patients with recurrent head and neck cancer to see if it improves survival compared to standard therapies. We will also evaluate how well patients tolerate the treatments and their quality of life.

Recurrent Head and Neck Squamous Cell Carcinoma>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesOncology

Irritable Bowel Syndrome: Saccharomyces boulardii CNCM I-745

We are studying whether a probiotic can help adults with non-constipated IBS feel better and improve their quality of life compared to a placebo.

Non-constipated Irritable Bowel Syndrome3-6 monthsConfirmation phase (III)≤5 visitsStandard MedicinesCost ReimbursementPartially RemoteGastroenterology

Recovery After Gallbladder Surgery: Esmolol vs. Sufentanil

We are comparing two medications to see which one helps patients recover more comfortably after laparoscopic gallbladder surgery. This study aims to improve patient comfort during the recovery process.

Laparoscopic Gallbladder Removal1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyInternal MedicineOrthopedics and TraumatologyOtolaryngology

Multiple Sclerosis: THC/CBD Oral Solution

We are studying an oral solution of THC and CBD for people with multiple sclerosis to see if it helps relieve chronic pain and improve other symptoms. This trial compares the treatment to a placebo to assess its effects.

Chronic Neuropathic Pain3-6 monthsEfficacy phase (II)6-10 visitsPost-Trial Drug AccessInvestigational MedicinesInternal MedicineNeurology

Metastatic Colorectal Cancer: RAXO Trial

We are studying how metastatic colorectal cancer behaves and the effectiveness of different treatments in patients. This research aims to improve surgical options and overall patient outcomes.

Advanced Colorectal Cancer>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesOncology

Breast Cancer: Typology-based Coaching with Ribociclib

We are studying whether personalized coaching and education can help patients with HR+ HER2- early breast cancer stay on their ribociclib treatment. This may improve their treatment experience and overall health outcomes.

Hormone Receptor Positive Breast CancerBreast Cancer>2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteInternal MedicineOncology

Chronic Cluster Headache: Low-Dose LSD Study

We are investigating whether a low dose of LSD can help reduce the frequency and severity of chronic cluster headaches. This study will assess both its effectiveness and safety compared to a placebo.

Chronic Cluster Headache≤3 monthsEfficacy phase (II)6-10 visitsInvestigational MedicinesCost ReimbursementPartially RemoteNeurology

Liver Health: Lepodisiran Study

We are studying how a single dose of Lepodisiran affects people with varying degrees of liver impairment and those with normal liver function. This research may help us understand the medication's safety and effectiveness in different liver conditions.

Liver ImpairmentSafety phase (I)HepatologyInternal Medicine

Type 2 Diabetes: RO7795081 Medication Study

We are comparing a new medication, RO7795081, with a placebo and semaglutide in people with type 2 diabetes. The study aims to see how well it controls blood sugar and affects body weight.

Type 2 Diabetes6-12 monthsEfficacy phase (II)11-15 visitsInvestigational MedicinesCost ReimbursementDiabetologyEndocrinology

Type 2 Diabetes: LY3457263 Treatment Study

We are testing a new medication, LY3457263, in people with type 2 diabetes who are not meeting their blood sugar goals on current treatments. The study will compare its effects to a placebo over 24 weeks.

Type 2 DiabetesEfficacy phase (II)11-15 visitsInvestigational MedicinesPartially RemoteEndocrinologyInternal Medicine

Milsaperidone for Major Depressive Disorder

We are studying whether adding milsaperidone to current antidepressant therapy can improve symptoms in patients with Major Depressive Disorder. The trial also looks at the safety of this new treatment compared to a placebo.

Major Depressive Disorder≤3 monthsConfirmation phase (III)Post-Trial Drug AccessInvestigational MedicinesPsychiatry

Scabies Treatment Comparison: Permethrin vs. Ivermectin

We are comparing the effectiveness of topical permethrin, oral ivermectin, and their combination for treating scabies. The goal is to find out which treatment works best and is safest for patients.

Scabies≤3 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesDermatologyInfectious Diseases

Heart Patients: Reduced Dose of Prasugrel

We are studying whether a lower dose of prasugrel is safe and effective for patients after heart procedures. The trial also looks at how well patients stick to this treatment compared to the usual approach.

Acute and Chronic Coronary SyndromeMonitoring phase (IV)No PlaceboStandard MedicinesPartially RemoteCardiologyInternal Medicine

Influenza Vaccine Study: OVX836

We are testing the OVX836 influenza vaccine in healthy adults to see if it can prevent influenza compared to a placebo. This study will also look at the vaccine's safety and how well it triggers an immune response.

Influenza6-12 monthsEfficacy phase (II)≤5 visitsInvestigational MedicinesPartially RemoteInfectious Diseases

Generalized Myasthenia Gravis: Descartes-08 Treatment

We are studying a new treatment called Descartes-08 for people with generalized myasthenia gravis. The trial aims to see if it helps improve daily activities and muscle strength compared to a placebo.

Generalized Myasthenia Gravis3-6 monthsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessInvestigational MedicinesNeurology

Immune Thrombocytopenia: NVG-2089 Treatment Study

We are testing a new intravenous treatment, NVG-2089, for individuals with Immune Thrombocytopenia. The study aims to evaluate its safety and how well it works in increasing platelet counts.

Immune Thrombocytopenia (ITP)Efficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementHematology

Bone Health: Everolimus and Exercise for Postmenopausal Women

We are studying if a combination of a medication and resistance training can improve bone formation in healthy postmenopausal women. This research may help in understanding better ways to support bone health.

Healthy Elderly Women3-6 monthsEfficacy phase (II)6-10 visitsStandard MedicinesCost ReimbursementGynecology and ObstetricsOrthopedics and Traumatology

PF-07999415: Tolerance Study in Healthy Adults

We are investigating how well different amounts of the medicine PF-07999415 are tolerated by healthy adults. This study will help us understand its effects in the body.

Metabolism and Nutrition Disorders6-12 monthsSafety phase (I)EndocrinologyInternal Medicine

Onychomycosis: DexULac® Treatment Study

We are studying how well DexULac® works for treating nail fungal infections and its impact on patients' quality of life. This trial will help us understand the effectiveness and safety of this treatment over time.

Nail Fungus (Onychomycosis)1-2 yearsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesDermatologyInfectious Diseases