Search Clinical Trials in the European Union

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561-580 of 1,738 trials

Dextroamphetamine for Amphetamine Dependence: A Clinical Trial

We are studying whether daily prescribed dextroamphetamine can help reduce illicit amphetamine use in adults with amphetamine and opioid dependencies. The trial also looks at its effects on mental health, physical health, and overall quality of life.

Comorbid Dependencies to Amphetamines and Opioids6-12 monthsEfficacy phase (II)Standard MedicinesPsychiatry

Heart Function Study: Dobutamine in ATTRwt Patients

We are investigating how different doses of dobutamine affect heart performance in patients with wild-type transthyretin amyloid cardiomyopathy. The study also looks at the safety of this treatment.

Wild-type Transthyretin Amyloid Cardiomyopathy1-2 yearsEfficacy phase (II)Standard MedicinesCardiologyInternal Medicine

Urothelial Cancer: Sacituzumab Govitecan Study

We are investigating a new treatment for patients with advanced urothelial cancer that cannot be removed by surgery. The study aims to see how effective and safe this treatment is compared to existing options.

Urothelial Cancer of the Renal Pelvis>2 yearsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteInternal MedicineOncologyUrology

Treatment-Resistant Depression: P-glycoprotein Study

We are investigating how a protein may affect people with treatment-resistant depression using advanced imaging. This study compares P-glycoprotein activity in those who do not respond to treatment with those who do.

Depression1-2 yearsEfficacy phase (II)No PlaceboStandard MedicinesPsychiatry

Ulcerative Colitis: GS-1427 Study

We are testing a new medication, GS-1427, for adults with moderately to severely active ulcerative colitis. The study aims to see if it can improve symptoms and achieve remission compared to a placebo.

Ulcerative Colitis1-2 yearsEfficacy phase (II)>20 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteGastroenterologyInternal Medicine

Cushing’s Syndrome: Fluasterone Buccal Tablet

We are studying whether fluasterone can help control high blood sugar in adults with Cushing’s syndrome. The trial will also look at its safety and effects on weight and cholesterol levels.

Cushing's Syndrome≤3 monthsEfficacy phase (II)Investigational MedicinesDiabetologyEndocrinologyInternal Medicine

Relapsed/Refractory T-Cell Leukemia: CD7 CAR T-Cell Therapy

We are testing a new type of T-cell therapy for children and young adults with relapsed or refractory T-cell leukemia or lymphoma. The study aims to find a safe dose and see how well it works.

T-cell Acute Lymphoblastic Leukemia/Lymphoma>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesHematologyOncologyPediatrics

Metastatic Pancreatic Adenocarcinoma: TTX-030 and Chemotherapy

We are studying if adding TTX-030 and possibly budigalimab to standard chemotherapy helps patients with untreated metastatic pancreatic cancer. This trial aims to evaluate the effectiveness and safety of these combinations.

Metastatic Pancreatic Cancer1-2 yearsEfficacy phase (II)>20 visitsNo PlaceboInvestigational MedicinesPartially RemoteGastroenterologyOncology

Inflammatory Bowel Disease: Adalimumab-680LT Study

We are investigating the safety and imaging of a new version of adalimumab for people with inflammatory bowel diseases. This study aims to see how well the drug targets inflammation and its potential effects on health.

Inflammatory Bowel Disease (IBD)6-12 monthsSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesGastroenterologyInfectious Diseases

Meningioma Treatment: Everolimus and 177Lu-DOTATATE

We are studying a new combination treatment for patients with grades 2 and 3 refractory meningioma. The goal is to see if this approach can help improve survival and manage tumor growth.

Malignant Meningiomas1-2 yearsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteNeurologyOncology

OXYTAHANE: Oxygen Therapy for Dystonic Attacks in Children

We are studying whether high-flow oxygen can help reduce acute dystonic and plegic attacks in children with alternating hemiplegia. The trial also looks at the impact on quality of life for both patients and caregivers.

Alternating Hemiplegia of Childhood≤3 monthsEfficacy phase (II)Standard MedicinesNeurologyPulmonology

Head and Neck Cancer: Amivantamab Treatment Study

We are studying the effects of amivantamab in patients with recurrent or metastatic head and neck squamous cell carcinoma. This trial looks at its use alone and with other standard treatments to see how well it works.

Recurrent Head and Neck CancerSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteOncology

Nipocalimab for Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

We are studying whether nipocalimab can help adults with CIDP delay relapse and improve their symptoms compared to a placebo. This trial will also assess the safety of the treatment.

Chronic Inflammatory Demyelinating PolyneuropathyEfficacy phase (II)Post-Trial Drug AccessInvestigational MedicinesPartially RemoteNeurology

Progressive Pulmonary Fibrosis: Inhaled Pirfenidone Study

We are testing an inhaled medication to see if it helps improve lung function and quality of life for people with Progressive Pulmonary Fibrosis. This study compares the medication to a placebo to assess its effects over time.

Progressive Pulmonary Fibrosis1-2 yearsEfficacy phase (II)6-10 visitsPost-Trial Drug AccessStandard MedicinesPulmonology

Scleroderma: Stem Cell Injections for Digital Ulcers

We are studying if injections of cultured fat cells can help heal stubborn digital ulcers in patients with scleroderma. This trial compares the treatment to a placebo to evaluate its effectiveness and safety.

Systemic Sclerosis>2 yearsEfficacy phase (II)6-10 visitsInvestigational MedicinesCost ReimbursementInternal MedicineRheumatology

Obstructive Sleep Apnea: Nacystelyn Inhaler Study

We are testing a new inhaler treatment for people with obstructive sleep apnea to see if it helps improve symptoms and reduce oxidative stress. The study also looks at the safety of this new treatment.

Obstructive Sleep Apnea≤3 monthsEfficacy phase (II)≤5 visitsStandard MedicinesCost ReimbursementNeurologyPsychiatryPulmonology

Lung Cancer: Chemoimmunotherapy with MEK Inhibitor

We are testing a new treatment combining chemotherapy and a MEK inhibitor for patients with metastatic non-squamous non-small cell lung adenocarcinoma. The goal is to see if this approach is safe and effective for those with low PD-L1 levels.

Non-Squamous Non-Small Cell Lung CancerSafety phase (I)Efficacy phase (II)Oncology

Advanced Epithelial Ovarian Cancer: Radspherin® Treatment

We are studying whether Radspherin® can improve survival and quality of life for patients with advanced ovarian cancer and peritoneal metastasis. This trial focuses on those scheduled for chemotherapy and surgery.

Peritoneal Carcinomatosis>2 yearsEfficacy phase (II)≤5 visitsStandard MedicinesCost ReimbursementPartially RemoteGynecology and ObstetricsOncology

Crohn's Disease: New Ultrasound Method with Microbubbles

We are testing a novel ultrasound technique using oral contrast to improve the detection of Crohn's disease complications. This study aims to see if it can identify issues like ulcers and blockages in the small intestine.

Crohn's Disease>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesGastroenterologyInternal Medicine

Chronic Kidney Disease: Camostat Treatment

We are studying the effects of Camostat on kidney function in patients with chronic kidney disease. The goal is to see if it helps with salt and water balance and blood pressure compared to healthy individuals.

Chronic Kidney Disease with Proteinuria1-2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesInternal MedicineNephrology