Search Clinical Trials in the European Union

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821-840 of 1,743 trials

Cystic Fibrosis: Anakinra Treatment Study

We are testing the safety and effectiveness of anakinra for adults and possibly adolescents with cystic fibrosis. The study aims to see if it improves lung function and quality of life.

Cystic Fibrosis>2 yearsEfficacy phase (II)Standard MedicinesInternal MedicinePulmonology

Metformin for Prolonging Pregnancy in Preterm Preeclampsia

We are studying whether metformin can help extend pregnancy by at least 5 days in individuals with preterm preeclampsia. Additionally, we aim to see if it improves health outcomes for mothers and their babies.

Pre-eclampsiaHELLP SyndromeHypertensive Disorders of Pregnancy>2 yearsConfirmation phase (III)Investigational MedicinesGynecology and ObstetricsInternal Medicine

Cirrhosis Treatment: Pegozafermin Study

We are studying a new medication, pegozafermin, for individuals with compensated cirrhosis due to MASH. The goal is to see if it can improve liver health and reduce related health risks compared to a placebo.

Chronic Liver Disease and Cirrhosis>2 yearsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteEndocrinologyHepatology

Crigler-Najjar Syndrome: GNT0003 Treatment Study

We are evaluating a new treatment called GNT0003 for adults with severe Crigler-Najjar syndrome who need daily phototherapy. The study aims to see if this treatment is safe and effective for those with pre-existing antibodies.

Crigler-Najjar Syndrome>2 yearsEfficacy phase (II)16-20 visitsNo PlaceboInvestigational MedicinesHepatologyInternal Medicine

CRISPR-TIL for Metastatic Melanoma

We are exploring a new treatment using CRISPR to modify immune cells for patients with metastatic melanoma. This study aims to see if it can improve the effectiveness of cancer therapy.

Advanced Melanoma>2 yearsSafety phase (I)Oncology

Acute Myeloid Leukemia: Gemtuzumab Ozogamicin with Chemotherapy

We are studying whether adding gemtuzumab ozogamicin to standard chemotherapy helps reduce minimal residual disease in adults with newly diagnosed acute myeloid leukemia. This research aims to improve treatment outcomes and overall survival.

Favorable-Intermediate-Risk Acute Myeloid Leukemia>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesHematologyOncology

Myopia in Children: Atropine Eyedrops Study

We are testing two concentrations of atropine eyedrops to see if they can slow the progression of myopia in children and teens aged 3 to under 18. The study will also look at safety and how vision affects daily life.

Myopia>2 yearsConfirmation phase (III)6-10 visitsInvestigational MedicinesOphthalmology

Septic Shock: Levetiracetam Treatment Study

We are studying whether early treatment with levetiracetam can help patients with septic shock stay awake and alert. The trial also examines its effects on survival and overall quality of life.

Septic Shock>2 yearsConfirmation phase (III)Standard MedicinesCost ReimbursementPartially RemoteInfectious DiseasesInternal MedicineNeurologyPulmonology

Heart Transplant in Children: Comparing Custodiol and Custodiol-N

We are studying the safety of two organ preservation solutions during heart transplants in children. This research aims to see which solution better supports recovery and overall health after surgery.

Heart Transplantation in Children>2 yearsEfficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesPartially RemoteCardiologyPediatrics

Locally Advanced NSCLC: New Chemoradiotherapy Approach

We are studying a new FDG-PET-based treatment for patients with locally advanced non-small cell lung cancer. The goal is to see if this method is safer and more effective than the standard treatment.

Stage III Non-Small Cell Lung Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Tau Imaging in Alzheimer's: Comparing PET Tracers

We are comparing three different PET tau tracers in volunteers to see which one best measures tau levels in the brain. This research may help improve diagnosis and treatment monitoring for Alzheimer's disease.

Cognitive Impairment>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesNeurologyOtolaryngology

Advanced Solid Tumors: DF6002 Treatment Study

We are investigating the safety and effectiveness of DF6002, alone and with Nivolumab, for patients with advanced solid tumors. This study aims to find the best dose and understand how well the treatment works.

Advanced Solid Tumors>2 yearsSafety phase (I)Efficacy phase (II)>20 visitsNo PlaceboInvestigational MedicinesOncology

B-Cell Acute Lymphoblastic Leukemia: Inotuzumab Ozogamicin Study

We are examining whether Inotuzumab can help adults with B-Cell Acute Lymphoblastic Leukemia achieve MRD negativity before stem cell transplantation. The study will also look at treatment safety and survival rates.

Acute Lymphoblastic Leukemia>2 yearsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesHematologyOncology

Mucositis Prevention: Dexpanthenol Mouth Rinse

We are studying whether a new mouth rinse can help reduce mouth sores in patients receiving radiation therapy. The trial compares this rinse to a placebo to see if it improves comfort and quality of life.

Radiation-Induced Oral Mucositis>2 yearsConfirmation phase (III)6-10 visitsInvestigational MedicinesDermatologyOncologyOtolaryngology

Brain Health: [11C]HSP990 PET Imaging

We are investigating a new imaging agent to measure Hsp90 levels in the brains of healthy individuals and those with neurodegeneration. This study aims to improve our understanding of brain aging and related diseases.

Alzheimer's DiseaseAmyotrophic Lateral SclerosisParkinson's Disease>2 yearsSafety phase (I)NeurologyOtolaryngology

B-cell Malignancies: NX-5948 Treatment Study

We are testing NX-5948 in adults with relapsed or refractory B-cell malignancies. The goal is to see if this new treatment can help those who have not responded to other therapies.

Relapsed/Refractory B-cell Malignancies>2 yearsSafety phase (I)Oncology

Melanoma: Direct Tumor Treatment with Microdosing

We are exploring a new way to deliver treatment directly into tumors for patients with advanced melanoma on anti-PD1 therapy. This pilot study aims to see if this method improves outcomes.

Malignant Melanoma>2 yearsSafety phase (I)DermatologyOncology

Head and Neck Cancer: New Treatment Combinations

We are comparing a new drug combination with a single drug for patients with locally advanced head and neck cancer. The aim is to see which treatment works better before starting chemoradiotherapy.

Locally Advanced Head and Neck Squamous Cell Carcinoma>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementOncology

Vitamin C Treatment for Cardiac Surgery Patients

We are studying whether vitamin C can reduce inflammation and improve recovery in patients undergoing cardiac surgery. This trial compares vitamin C treatment to standard care to see which is more effective.

Cardiovascular Illness>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesPartially RemoteCardiologyInternal Medicine

Advanced Solid Tumors: MOST Plus Treatment Study

We are studying a new maintenance treatment for patients with advanced solid tumors to see if it helps keep the disease stable after initial therapy. This trial compares ongoing treatment with stopping the therapy to understand the best approach.

Advanced or Metastatic Cancers>2 yearsEfficacy phase (II)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesOncology