Search Clinical Trials in the European Union

>2 years
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901-920 of 1,743 trials

Colchicine for Knee and Hip Osteoarthritis

We are studying whether colchicine can help reduce the need for knee or hip replacements in people with osteoarthritis. The trial also looks at its effects on pain, physical function, and overall quality of life.

Osteoarthritis>2 yearsConfirmation phase (III)6-10 visitsStandard MedicinesCost ReimbursementPartially RemoteOrthopedics and TraumatologyRheumatology

NRAS Mutant Melanoma: Naporafenib + Trametinib Study

We are testing a new combination therapy for patients with previously treated NRAS mutant cutaneous melanoma. The goal is to see if it works better than standard treatment options in improving survival and managing the disease.

Unresectable or Metastatic NRAS Mutant Cutaneous Melanoma>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesDermatologyOncology

Community-Acquired Pneumonia: Inhaled Levofloxacin Study

We are investigating whether inhaling levofloxacin helps improve health in patients with community-acquired pneumonia. This study includes individuals with and without pre-existing lung disease.

Community-acquired Pneumonia>2 yearsEfficacy phase (II)Post-Trial Drug AccessStandard MedicinesInfectious DiseasesPulmonology

Metastatic Breast Cancer: New HER2 Imaging Test

We are studying a new imaging method using 68Ga-ABS011 to see how well it detects HER2 status in metastatic breast cancer and other solid tumors. This may help improve diagnosis and treatment management.

Metastatic Breast Cancer>2 yearsEfficacy phase (II)Confirmation phase (III)No PlaceboStandard MedicinesCost ReimbursementInternal MedicineOncology

Prostate Cancer: CC 1 Antibody Study

We are evaluating a new antibody treatment for men whose prostate cancer has returned. The study aims to assess its safety and early signs of effectiveness.

Recurrent Prostate Cancer>2 yearsSafety phase (I)OncologyUrology

Hepatocellular Carcinoma: Triple Treatment Study

We are studying a combination of three medications for patients with non-resectable liver cancer. The goal is to see if this approach improves symptoms and quality of life compared to past treatments.

Non-resectable Hepatocellular Carcinoma>2 yearsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesHepatologyOncology

Advanced Solid Tumors: KQB198 Treatment Study

We are investigating a new treatment called KQB198 for individuals with advanced solid tumors. The study aims to assess its safety and effectiveness, both alone and with other therapies.

Solid Tumour>2 yearsSafety phase (I)Oncology

Advanced Blood Cancers: KQB198 Treatment Study

We are investigating a new treatment called KQB198 for individuals with advanced hematologic malignancies. The study aims to assess its safety and effectiveness, both alone and with other therapies.

Advanced Blood Cancer>2 yearsSafety phase (I)HematologyOncology

HYSTINDO Study: Indocyanine Green in Laparoscopic Hysterectomy

We are exploring how a special dye can help surgeons see blood flow in the vaginal area during laparoscopic hysterectomy. This study aims to improve surgical safety and outcomes for patients.

Total Hysterectomy>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGynecology and ObstetricsInternal Medicine

Fanconi Anemia: Afatinib for Advanced Squamous Cell Carcinoma

We are studying whether Afatinib can help patients with Fanconi anemia who have advanced squamous cell carcinoma in the head and neck. The trial will assess its effectiveness and safety compared to current treatment options.

Advanced Squamous Cell Carcinoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesHematologyOncology

Breast Cancer: Alisertib with Hormone Therapy

We are studying how well alisertib works with hormone therapy for patients with recurrent or metastatic hormone receptor positive, HER2 negative breast cancer. Our goal is to find the best dose and assess safety and effectiveness.

Hormone Receptor Positive, HER2 Negative Metastatic Breast Cancer>2 yearsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteGynecology and ObstetricsOncology

Advanced Cancer: BI 1703880 with Ezabenlimab

We are testing how well different doses of BI 1703880 work with ezabenlimab in people with advanced solid tumors. This study aims to see how well these treatments are tolerated.

Advanced Solid Tumours>2 yearsSafety phase (I)Oncology

Posaconazole for Fungal Infection Prevention in Stem Cell Transplant Patients

We are studying whether posaconazole can effectively prevent fungal infections in patients receiving stem cell transplants. This research aims to understand how well the medication works and its impact on patient recovery.

Healthy Participants>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesHematologyInfectious Diseases

Diabetic Ketoacidosis: Comparing Ringer Lactate and Saline

We are studying whether Ringer Lactate is more effective than isotonic saline in treating severe diabetic ketoacidosis in ICU patients. This may help improve treatment outcomes for those affected.

Diabetic Ketoacidosis>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesEndocrinologyInternal Medicine

Advanced Cancer: IO102-IO103 with Pembrolizumab

We are studying a new treatment combination for patients with metastatic non-small cell lung cancer, squamous cell carcinoma of the head and neck, or metastatic urothelial bladder cancer. The goal is to evaluate its effectiveness and safety as a first-line therapy.

Metastatic Squamous Cell Carcinoma of Head and NeckMetastatic Urothelial Bladder CancerMetastatic Non-Small Cell Lung Cancer>2 yearsEfficacy phase (II)16-20 visitsNo PlaceboInvestigational MedicinesOncology

Locally-Advanced Rectal Cancer: Tailored Treatment Study

We are studying a personalized treatment plan for patients with locally-advanced rectal cancer who respond well to initial chemotherapy. The goal is to see if this approach maintains effective surgery outcomes while reducing treatment intensity.

Rectal Cancer>2 yearsEfficacy phase (II)Confirmation phase (III)No PlaceboStandard MedicinesOncology

Alzheimer's Disease: Understanding Tau Spread and Language Function

We are studying how tau protein spreads in the brain during different stages of Alzheimer's disease and its impact on language abilities. This research may help us understand cognitive changes in patients.

Early Alzheimer's Disease>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesNeurologyPsychiatry

Sodium Thiosulfate Injections for Ectopic Calcifications

We are studying whether injections of sodium thiosulfate can help reduce calcifications and ossifications in patients with certain autoimmune conditions. This trial will also look at the treatment's safety and its impact on pain and quality of life.

Ectopic Calcification and Ossification>2 yearsEfficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesCost ReimbursementDermatologyRheumatology

Daratumumab for Very High-Risk T-Cell Acute Lymphoblastic Leukemia

We are studying whether adding daratumumab to standard treatment helps adults with very high-risk T-ALL achieve better disease control. This trial will also assess the safety and effectiveness of this combination therapy.

Very High-Risk T-Lineage Acute Lymphoblastic Leukemia>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesHematologyOncology

Hodgkin's Lymphoma: Atezolizumab and BEGEV Treatment

We are studying a new combination treatment for patients with relapsed or refractory Hodgkin's lymphoma to see if it helps improve response rates before stem-cell transplantation. This trial will also evaluate the safety and tolerability of this treatment approach.

Hodgkin's Lymphoma>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesHematologyOncology