Search Clinical Trials in the European Union

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1141-1160 of 1,743 trials

Rare Cancers: Targeted Drug Study

We are exploring how well existing targeted cancer drugs work for patients with rare and hard-to-treat cancers. The study will also look at any serious side effects from these treatments.

Cancer>2 yearsEfficacy phase (II)6-10 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesOncology

Knee Surgery Pain Relief: Nefopam Study

We are investigating whether an oral medication called nefopam can reduce morphine use after total knee replacement surgery. This study aims to improve pain management for adults recovering from this procedure.

Postoperative Pain After Knee Surgery>2 yearsSafety phase (I)Efficacy phase (II)Investigational MedicinesInternal MedicineOrthopedics and Traumatology

Acute Myocarditis: Ibuprofen vs. Standard Pain Relief

We are studying whether ibuprofen can better improve heart health compared to regular pain relief in patients with acute myocarditis. This trial focuses on how these treatments affect heart imaging results after six months.

Acute Myocarditis>2 yearsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesCardiologyInternal Medicine

Cardiogenic Shock: Levosimendan vs. Placebo

We are studying whether early use of levosimendan can improve health outcomes in patients with cardiogenic shock compared to a placebo. The goal is to see if it reduces the need for life support and improves survival rates.

Cardiogenic Shock>2 yearsConfirmation phase (III)Investigational MedicinesPartially RemoteCardiologyInternal Medicine

Leiomyosarcoma: Trabectedin vs. Gemcitabine

We are comparing two treatments, Trabectedin and Gemcitabine, for patients with advanced leiomyosarcoma who have already received chemotherapy. The goal is to see which treatment works better in slowing down cancer growth and improving survival.

Leiomyosarcoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Giant Cell Arteritis and Polymyalgia Rheumatica: Hydrocortisone Study

We are investigating whether hydrocortisone can help patients with GCA and PMR who report symptoms of adrenal insufficiency after stopping glucocorticoids. This study aims to provide better treatment options for these patients.

Tertiary Adrenal Insufficiency>2 yearsMonitoring phase (IV)≤5 visitsStandard MedicinesCost ReimbursementPartially RemoteEndocrinologyRheumatology

Cerebrolysin for CADASIL Patients

We are studying whether Cerebrolysin is safe and effective for individuals with genetically confirmed CADASIL. This trial compares it to a placebo to understand its overall benefits.

CADASIL>2 yearsEfficacy phase (II)>20 visitsStandard MedicinesNeurology

Achondroplasia: Long-Term Study of Infigratinib

We are studying the long-term safety and effects of Infigratinib in children with Achondroplasia. The goal is to see how it impacts their growth and overall health.

Achondroplasia>2 yearsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesOrthopedics and TraumatologyPediatrics

Advanced Solid Tumors: GSK5733584 Injection

We are evaluating a new injection for people with advanced solid tumors to see if it is safe and how well it works. This study aims to understand the drug's effects on patients.

Ovarian Tumors>2 yearsSafety phase (I)Efficacy phase (II)Oncology

Preventing Constipation After Hip Surgery: Laxative Study

We are exploring which laxatives work best to prevent constipation in patients recovering from hip fracture surgery. This research aims to improve comfort and recovery after surgery.

Hip Fracture>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyOrthopedics and Traumatology

Cluster Headache Study: Understanding Brain Activity

We are exploring how brain activity and receptor availability differ in people with cluster headaches during active and inactive periods. This research may help us learn more about the condition and its effects on the brain.

Nervous System Diseases>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementNeurology

Glucose Distribution in Severely Burned Adults

We are studying how glucose is distributed in the bodies of severely burned adults during their first few days of treatment. This research may help us understand its relationship with other health factors and improve patient care.

Severe Burns>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesEndocrinologyInternal MedicineOrthopedics and Traumatology

Pancreatic Cancer: TCR-Modified T-Cell Therapy

We are studying a new therapy using modified T-cells for adults with advanced pancreatic cancer that has specific genetic mutations. The trial aims to assess safety and how well this treatment may work.

Pancreatic Cancer>2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesCost ReimbursementOncology

Opioid Dependency Treatment: Suboxone vs. Methadone

We are comparing the effectiveness of Suboxone and methadone in reducing opioid misuse for patients with chronic pain. The study also looks at how these treatments affect pain relief, well-being, and cognitive function.

Opioid Use Disorder>2 yearsMonitoring phase (IV)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementInternal MedicinePsychiatry

Locally Advanced Rectal Cancer: CApecitabine and Temozolomide Study

We are studying a new treatment combining capecitabine and temozolomide for patients with specific types of locally advanced rectal cancer. The goal is to see if this combination improves tumor response and surgical outcomes.

Locally Advanced Rectal Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Metastatic Breast Cancer: Next Generation Sequencing Oncochip

We are studying a new sequencing tool to help decide the best treatment for metastatic breast cancer patients. The goal is to see if it improves survival and response compared to standard chemotherapy.

Breast Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

New Treatment for Limbal Stem Cell Deficiency: Oral Mucosa Cells

We are testing a new method using cultured cells from the mouth to help people with limbal stem cell deficiency. This study aims to see if this treatment can improve eye health and vision.

Limbal Stem Cell Deficiency>2 yearsSafety phase (I)Efficacy phase (II)Ophthalmology

Hepatocellular Carcinoma: Durvalumab and Tremelimumab with Y-90 SIRT

We are studying a combination of immunotherapy and radiation therapy for patients with intermediate stage liver cancer who cannot have surgery. The goal is to see if this treatment can help shrink tumors and improve survival.

Non-resectable Hepatocellular Carcinoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesPartially RemoteHepatologyOncology

Advanced Breast Cancer: Capivasertib and Fulvestrant Study

We are researching the combination of capivasertib and fulvestrant for patients with HR+/HER2- advanced breast cancer who have not responded to standard treatments. The study aims to evaluate treatment effectiveness and safety in real-world clinical practice.

Advanced Breast Cancer>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteOncology

TBR1-Related Neurocognitive Disorder: Lithium Carbonate Study

We are studying whether lithium carbonate can improve behavior and communication in patients with TBR1-related neurocognitive disorder. This trial will also assess the treatment's safety and overall impact on quality of life.

TBR1 Variant>2 yearsSafety phase (I)Efficacy phase (II)11-15 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteNeurologyPsychiatry