Search Clinical Trials in the European Union

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1361-1380 of 1,743 trials

Oxybutynin for Boys with Posterior Urethral Valves

We are studying whether early treatment with oxybutynin improves bladder function in boys after surgery for posterior urethral valves. The trial also looks at the safety of the medication and its effects on urinary tract infections.

Urethral Posterior Valve>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesPediatricsUrology

Acute Kidney Injury: Angiotensin Receptor Blocker Study

We are studying whether an angiotensin receptor blocker can improve heart and kidney health in patients recovering from acute kidney injury after ICU discharge. This trial will help us understand its effects on overall health and safety.

Acute Kidney Injury>2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesCardiologyInternal MedicineNephrology

Tarlatamab for Advanced Small-Cell Lung Cancer

We are studying a new treatment for patients with metastatic or locally advanced small-cell lung cancer and other neuroendocrine carcinomas. The goal is to see how well it works and to understand its safety.

Metastatic Small Cell Lung Cancer>2 yearsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementInternal MedicineOncology

Brain Metastases Detection: PET-DOPA Imaging Study

We are studying a new imaging method to detect untreated brain metastases in patients with lung, breast, or melanoma cancer. This research aims to improve how we identify and understand these tumors.

Brain Metastases from Cancer>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesNeurologyOncology

Non-Small Cell Lung Cancer: MB12 vs. Keytruda

We are comparing a new treatment, MB12, to Keytruda for patients with non-small cell lung cancer. The study aims to understand differences in effectiveness and safety between the two options.

Advanced Non-Squamous Non-Small Cell Lung Cancer>2 yearsConfirmation phase (III)Oncology

Biliary Tract Cancer: Ivonescimab vs. FOLFOX

We are testing a new treatment, ivonescimab, against standard chemotherapy for patients with advanced biliary tract cancer. The goal is to see if it helps patients live longer and feel better.

Advanced Biliary Tract Cancer>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

Advanced Solid Tumors: 89Zr-Df-crefmirlimab Imaging Study

We are studying a new imaging method to see how well it shows cancer cells in patients with advanced solid tumors. This may help us understand treatment responses and immune cell activity better.

Metastatic Solid Tumors>2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesCost ReimbursementOncology

C3 Glomerulopathy: Aliskiren vs. Enalapril

We are studying whether the medication aliskiren can improve kidney function in people with C3 glomerulopathy compared to the standard treatment, enalapril. This trial aims to assess its safety and effectiveness in reducing kidney disease markers.

C3 Glomerulopathy>2 yearsEfficacy phase (II)11-15 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesInfectious DiseasesNephrology

Histiocytosis: Fludeoxyglucose (18F-FDG) Imaging Study

We are examining how fludeoxyglucose (18F-FDG) in PET/CT scans can help monitor juvenile patients with histiocytosis. The study will assess its safety and potential benefits for those with specific mutations.

Erdheim-Chester DiseaseLangerhans Cell SarcomaRosai-Dorfman Syndrome>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesHematologyOtolaryngology

Histiocytosis in Children: Trametinib Study

We are testing the safety and effectiveness of trametinib in children with refractory histiocytosis. The goal is to find the best dosage and timing for treatment after other therapies have failed.

Erdheim-Chester DiseaseRosai-Dorfman SyndromeLangerhans' Cell Histiocytosis>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncologyPediatrics

Mitral Valve Surgery: Landiolol Study

We are investigating whether Landiolol can help improve heart function and reduce complications after mitral valve surgery. This study looks at its effects on heart health and recovery in patients undergoing this procedure.

Low Cardiac Output Syndrome>2 yearsMonitoring phase (IV)Investigational MedicinesCardiologyInternal Medicine

Lung Cancer: Pembrolizumab Maintenance Study

We are studying whether continuing pembrolizumab treatment helps patients with stage IV lung cancer maintain disease control after initial chemotherapy. This trial will also look at the quality of life and side effects experienced by participants.

Non-Small Cell Lung Cancer>2 yearsEfficacy phase (II)Confirmation phase (III)No PlaceboStandard MedicinesOncology

Rapamycin for Drug-Resistant Epilepsy in Children

We are studying the safety and effectiveness of rapamycin for children with drug-resistant epilepsy caused by rare central nervous system diseases. This trial aims to find better treatment options for these challenging conditions.

Epilepsy and Related Disorders>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesNeurology

High-Grade Glioma in Children: Rapamycin Study

We are evaluating the safety and effectiveness of rapamycin for treating high-grade gliomas in children. This study aims to understand how well it works and if genetic factors play a role in treatment response.

High Grade Glioma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncologyPediatrics

DIPG Treatment: Targeted Drug Study for Children

We are testing how well certain drugs work for children with diffuse intrinsic pontine glioma (DIPG) based on their tumor's genetic makeup. The goal is to find safer and more effective treatments tailored to individual patients.

Diffuse Intrinsic Pontine Glioma>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesNeurologyOncologyPediatrics

Acute Cholecystitis: Antibiotic Treatment Comparison

We are studying whether a single dose of antibiotics before gallbladder surgery is as effective as continuous antibiotics in preventing infections. This trial aims to improve patient outcomes during and after surgery.

Acute Cholecystitis>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesGastroenterologyInternal Medicine

Lung Cancer Treatment: Chemotherapy + Atezolizumab

We are studying a combination of chemotherapy and atezolizumab for patients with stage IIIA and IIIB non-small cell lung cancer. This trial aims to see if this approach improves survival and treatment outcomes before and after surgery.

Non-small Cell Lung Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Out-of-Hospital Cardiac Arrest: DANOHCA Study

We are testing different treatments, including medications and positioning, for patients who have had a cardiac arrest outside the hospital. Our goal is to see which methods may improve survival and recovery.

Cardiac Arrest>2 yearsConfirmation phase (III)Standard MedicinesCardiologyInternal Medicine

Cardiac Surgery: Dexamethasone and Olanzapine Study

We are investigating whether dexamethasone and olanzapine improve recovery for adults undergoing heart surgery. The study also looks at different management techniques to enhance patient outcomes after surgery.

Ischemic Heart DiseaseHeart Valve Surgery>2 yearsConfirmation phase (III)Standard MedicinesCardiologyInternal Medicine

Solid Tumors: MK-0472 Study

We are investigating the effects of MK-0472 in people with solid tumors. This study aims to understand how well this treatment works compared to standard options.

Solid Tumors>2 yearsSafety phase (I)Oncology