Search Clinical Trials in the European Union

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1401-1420 of 1,743 trials

Immune Thrombocytopenia: Rituximab with Belimumab

We are studying whether adding belimumab to rituximab helps adults with persistent immune thrombocytopenia. This trial will compare the effects of the combination treatment to rituximab alone.

Immune Thrombocytopenia>2 yearsConfirmation phase (III)6-10 visitsStandard MedicinesHematology

Recurrent Brain Tumors in Children: Ultrasound Blood-Brain Barrier Study

We are evaluating a new ultrasound device to safely open the blood-brain barrier before chemotherapy in children with recurrent brain tumors. This study aims to see how well this method works and its effects on tumor progression.

Glioblastoma>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesNeurologyOncologyPediatrics

COPD Management: Azithromycin Based on Mucus Properties

We are studying whether prescribing azithromycin based on mucus rheology helps reduce COPD flare-ups compared to standard treatment. This trial aims to improve care for patients with chronic airway disease.

Chronic Obstructive Pulmonary Disease>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesInternal MedicinePulmonology

Early Breast Cancer: Trastuzumab-Deruxtecan vs. Standard Care

We are studying a new treatment for early breast cancer patients who have had a molecular relapse. The trial aims to see if this new therapy clears cancer markers more effectively than standard treatments.

HER2-positive Breast CancerBreast Cancer>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesOncology

B-Cell Lymphoma: Valemetostat Tosylate Study

We are testing a new treatment for patients with relapsed or refractory B-cell lymphoma. The study aims to see how well it works and its safety across different lymphoma types.

Relapse/Refractory B-Cell Lymphoma>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementHematologyOncology

Stroke Prevention: ASPIRING Study

We are investigating if an oral antiplatelet drug can help prevent serious heart and brain events in stroke survivors. This study compares the effects of this medication to standard care without antiplatelet drugs.

Intracerebral Hemorrhage>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCost ReimbursementPartially RemoteCardiologyInternal MedicineNeurology

High-Risk Breast Cancer: Personalized Chemotherapy Study

We are investigating a new chemotherapy treatment for patients with high-risk, HER2-negative breast cancer to see if it improves survival rates compared to standard therapies. This trial is for individuals with specific genetic profiles, including those without known BRCA mutations.

Breast Cancer>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesOncology

Intensive Care: INCEPT Trial

We are studying different treatments for adults admitted to the intensive care unit to see how they affect recovery. This trial aims to improve care by understanding the best practices among clinicians.

Intensive Care>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesCardiologyInfectious DiseasesInternal MedicineNeurologyPulmonology

Colorectal Cancer: Dendritic Cell Vaccine Study

We are testing a personalized vaccine made from patients' own cells after surgery for stage IV colorectal cancer. The goal is to see if it safely boosts the immune response against cancer.

Stage IV Colorectal Cancer>2 yearsEfficacy phase (II)6-10 visitsNo PlaceboInvestigational MedicinesOncology

B-Cell Malignancies: BGB-16673 Treatment Study

We are investigating the safety and effectiveness of BGB-16673 combined with other treatments for patients with relapsed or refractory B-cell malignancies. This study aims to find the best dose and assess how well the treatment works.

Relapsed or Refractory B-Cell Malignancies>2 yearsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteOncology

Wrist Osteoarthritis: Microfat and PRP Injection Study

We are testing whether injections of your own fat and platelet-rich plasma can help relieve pain in wrist osteoarthritis compared to standard surgery. This study aims to see if the new treatment is just as effective and safe.

Wrist Osteoarthritis>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesOrthopedics and TraumatologyRheumatology

Acute Demyelinating Syndromes in Children: Azathioprine vs. Rituximab

We are studying whether starting treatment immediately with azathioprine or rituximab helps children with anti-MOG antibodies better than delaying treatment until a second attack. The goal is to see which method reduces relapses and improves health outcomes.

Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)>2 yearsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteNeurologyRheumatology

Hereditary Angioedema: Deucrictibant Extended-Release Tablet

We are studying a new oral medication to prevent angioedema attacks in adolescents and adults with hereditary angioedema. The trial will evaluate its safety, effectiveness, and impact on quality of life.

Hereditary Angioedema>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteAllergologyInternal Medicine

Caspofungin for ICU Yeast Infections

We are studying whether caspofungin can help patients in the ICU with yeast infections in the abdomen. The trial compares this treatment to a placebo to see if it improves recovery and reduces mortality.

Yeast Intra-Abdominal Infection (Peritonitis)>2 yearsConfirmation phase (III)6-10 visitsInvestigational MedicinesInfectious DiseasesInternal Medicine

Kidney Biopsy: Desmopressin Safety Study

We are studying whether Desmopressin can help prevent bleeding during kidney biopsies. This trial looks at its effects on safety and recovery time for patients.

Glomerulonephritis>2 yearsConfirmation phase (III)Standard MedicinesInternal MedicineNephrology

Metastatic Thyroid Cancer: Personalized 131I Therapy

We are studying if a personalized approach to administering radioactive iodine can improve treatment outcomes for patients with metastatic thyroid cancer. This trial also looks at how genetic factors may affect treatment effectiveness.

Thyroid Cancer>2 yearsEfficacy phase (II)Standard MedicinesOncology

Liver Cirrhosis: RTX001 Macrophage Therapy

We are studying a new treatment using RTX001 autologous macrophages for people with decompensated liver cirrhosis. The trial aims to evaluate its safety and effectiveness in improving liver function.

Liver Cirrhosis>2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteHepatologyInternal Medicine

Cancer Treatment: Decitabine and Cedazuridine

We are studying how safe and effective a combination of Decitabine and Cedazuridine is for cancer patients with kidney problems. This research aims to improve treatment options for those affected.

Acute Myeloid Leukemia (AML)Myelodysplastic Syndrome (MDS)Solid Tumors>2 yearsSafety phase (I)NephrologyOncology

Oxytocin for Children with Autism and Intellectual Disabilities

We are studying whether oxytocin can safely support educational measures for children aged 6 to 12 with autism and intellectual disabilities. This trial will help us understand its feasibility and safety in managing challenging behaviors.

Autism Spectrum Disorder and Intellectual Disability>2 yearsEfficacy phase (II)Confirmation phase (III)Standard MedicinesPediatricsPsychiatry

Metastatic Colorectal Cancer: Nivolumab and Ipilimumab Study

We are testing a combination of two immunotherapy drugs for patients with metastatic colorectal cancer that is resistant to previous treatments. This study aims to find out if this combination can improve outcomes for these patients.

Metastatic Colorectal Cancer>2 yearsEfficacy phase (II)Oncology