Search Clinical Trials in the European Union

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1521-1540 of 1,743 trials

Pancreas and Kidney Transplant: Sirolimus vs. Mycophenolate Mofetil

We are comparing two medications to see which one may reduce the risk of hernias after simultaneous pancreas and kidney transplants in people with type 1 diabetes. We also want to understand their effects on diabetes complications.

End-stage Kidney Disease in Type 1 DiabetesTransplantation ComplicationsSimultaneous Pancreas and Kidney Transplantation>2 yearsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesGastroenterologyInternal MedicineNephrologyOncologyUrology

Total Hip Replacement: Tranexamic Acid Injection

We are studying whether injecting Tranexamic acid into the hip joint can reduce blood loss during total hip replacement surgery. This trial compares the effects of TXA with a placebo to see which is more effective.

Hip Osteoarthritis>2 yearsEfficacy phase (II)Standard MedicinesHematologyOrthopedics and Traumatology

Sacubitril/Valsartan for Arrhythmogenic Right Ventricular Cardiomyopathy

We are studying whether sacubitril/valsartan can help prevent disease progression in patients with ARVC. This trial aims to assess its effects on heart tissue changes.

Arrhythmogenic Cardiomyopathy>2 yearsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesCardiology

Breast Cancer: Palbociclib and Fulvestrant Study

We are investigating if a new treatment combination can help prevent relapse in patients with ER positive HER2 negative breast cancer. This study focuses on those with detectable tumor DNA during treatment.

ER Positive HER2 Negative Breast Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Chronic Pain After Mastectomy: Comparing Treatments

We are studying the effectiveness of Serratus Plane Block, capsaicin, and botulinum toxin type A for managing chronic neuropathic pain after mastectomy. This trial aims to find out which treatment offers better pain relief for those not helped by standard therapies.

Post-Mastectomy Pain Syndrome>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesPartially RemoteInternal MedicineNeurologyOncology

Prostate Cancer: BMS-986365 vs. Standard Treatment

We are comparing a new medication, BMS-986365, to standard treatments for men with metastatic castration-resistant prostate cancer. The study aims to see if the new drug can better delay disease progression and improve overall health.

Metastatic Castration-resistant Prostate Cancer>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementOncology

Nasopharyngeal Cancer: Nivolumab Treatment Study

We are studying the effectiveness of Nivolumab for patients with nasopharyngeal cancer who have progressed after chemotherapy. We also want to understand how safe this treatment is for these patients.

Nasopharyngeal Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesPartially RemoteOncology

Throat and Larynx Cancer: Low-Dose Radiation Therapy

We are studying a new treatment combining low doses of radiation and chemotherapy for patients with advanced throat and larynx cancer. The goal is to see if this approach improves treatment outcomes and is well-tolerated.

Throat and Larynx Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncologyOtolaryngology

Heart Inflammation: Immunosuppressive Treatment Study

We are studying whether a combination of prednisone and azathioprine can improve heart function in patients with inflammatory heart disease. This trial compares the treatment to a placebo to see if it offers any benefits.

Myocarditis>2 yearsMonitoring phase (IV)11-15 visitsStandard MedicinesCardiologyInternal Medicine

Infantile Spasms: Vigabatrin for High-Risk Children

We are studying whether vigabatrin can prevent infantile spasms in children under 1 year old who are at high risk due to conditions like tuberous sclerosis. This research aims to improve outcomes for these vulnerable infants.

High-Risk Infantile Spasm Syndrome>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesNeurology

Alcohol Use Disorder: Psilocybin Treatment

We are studying if a single dose of psilocybin can help reduce heavy drinking in people with alcohol use disorder. This trial compares the effects of psilocybin to a placebo over 12 weeks.

Alcohol Use Disorder>2 yearsSafety phase (I)Efficacy phase (II)6-10 visitsInvestigational MedicinesCost ReimbursementPsychiatry

Preventing Infections After Hysterectomy: Azithromycin vs. Cefuroxime

We are studying whether a combination of azithromycin and cefuroxime can better prevent infections after hysterectomy compared to cefuroxime alone. This research aims to improve antibiotic use in surgical settings.

Undergoing Hysterectomy>2 yearsMonitoring phase (IV)Investigational MedicinesGynecology and ObstetricsInfectious Diseases

Post-Surgery Pain Management: Comparing Two Techniques

We are studying the effectiveness of two different nerve block methods for pain relief after laparoscopic colon surgery. Our goal is to see if these methods work better than traditional oral pain medications.

Colon Surgery for Cancer or Diverticulosis>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOtolaryngology

Chronic Inflammatory Demyelinating Polyneuropathy: DNTH103 Treatment Study

We are studying a new treatment called DNTH103 for adults with Chronic Inflammatory Demyelinating Polyneuropathy. The trial aims to see if it can help reduce relapses and improve overall health compared to a placebo.

Chronic Inflammatory Demyelinating Polyneuropathy>2 yearsEfficacy phase (II)>20 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementNeurology

Severe Asthma: Tezepelumab Treatment

We are exploring how Tezepelumab may improve airway barrier function in patients with severe asthma, including those with chronic rhinosinusitis. This study looks at the effects of the treatment on the airways' response to harmful substances.

Severe Asthma with Chronic Rhinosinusitis and Nasal PolypsSevere Asthma without Chronic Rhinosinusitis>2 yearsMonitoring phase (IV)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesAllergologyOtolaryngologyPulmonology

Neovascular Age-Related Macular Degeneration: Faricimab Injections

We are studying the safety and long-term effectiveness of faricimab injections for people with neovascular age-related macular degeneration. The goal is to see if it improves vision and how well it works over time.

Neovascular Age-Related Macular Degeneration>2 yearsConfirmation phase (III)Monitoring phase (IV)Post-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementOphthalmology

Rheumatoid Arthritis: ABO21009 Treatment Study

We are testing a new treatment called ABO21009 in healthy volunteers and patients with rheumatoid arthritis. The goal is to see how it compares to a placebo in terms of safety and effects.

Rheumatoid Arthritis>2 yearsSafety phase (I)Rheumatology

Severe Asthma: Dupilumab Treatment Study

We are investigating how Dupilumab affects mucus buildup and immune responses in patients with severe asthma. This study aims to improve understanding of asthma management and treatment options.

Severe Asthma>2 yearsConfirmation phase (III)Monitoring phase (IV)11-15 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteAllergologyPulmonology

5-Aminolevulinic Acid (5-ALA) for Brain Tumors in Kids

We are studying the safety of 5-ALA during surgeries for children and adolescents with brain tumors. The trial will help us understand how well it identifies tumor cells and its effects on young patients.

Brain Tumor>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncologyPediatrics

Advanced Solid Tumors: PM54 Treatment Study

We are testing a new drug called PM54 in patients with advanced solid tumors to see how safe it is and how it works. This study aims to explore new treatment options for those with limited choices.

Selected Advanced Solid Tumors>2 yearsSafety phase (I)Oncology