Search Clinical Trials in the European Union

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1541-1560 of 1,743 trials

Advanced Solid Tumors: YL201 Treatment Study

We are investigating a new treatment called YL201 for patients with advanced solid tumors. The goal is to see how effective and safe it is compared to current options.

Advanced Cancer>2 yearsSafety phase (I)Oncology

Lung Surgery: Oxygen Delivery Techniques

We are comparing three methods of oxygen administration during lung surgery to see how they affect recovery and complications. This study aims to find the best approach for improving patient outcomes after surgery.

Lung Resection Surgery>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineOtolaryngologyPulmonology

Central Retinal Artery Occlusion: Tenecteplase Study

We are investigating whether tenecteplase can help improve vision in patients with central retinal artery occlusion when given shortly after symptoms begin. This study compares it to standard treatment to see which is more effective.

Central Retinal Artery Occlusion>2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesCardiologyNeurologyOphthalmology

Cardiovascular Risk: Allopurinol Study

We are investigating if allopurinol can lower cardiovascular risks in patients with high risk, including those experiencing long-COVID. This study focuses on individuals over 60 years old as well.

Heart FailureHypertensionAtrial Fibrillation>2 yearsConfirmation phase (III)6-10 visitsStandard MedicinesCardiologyEndocrinologyInternal Medicine

Advanced Basal Cell Carcinoma: Cemiplimab Treatment Study

We are studying the effectiveness and safety of Cemiplimab for patients with advanced basal cell carcinoma. This trial aims to see how well it works as a first-line treatment and to identify factors that may affect treatment outcomes.

Basal Cell Carcinoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesDermatologyOncology

Glioblastoma: Radiodynamic Therapy with 5-Aminolevulinic Acid

We are testing a new treatment combining radiodynamic therapy and 5-Aminolevulinic acid for patients with a first recurrence of glioblastoma. The goal is to find the highest safe dose and ensure it can be tolerated.

Recurrent Glioblastoma>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesOncology

Inhaled Sevoflurane for Sedation in Critically Ill Patients

We are studying whether inhaled sevoflurane improves breathing and safety in ICU patients at risk for ARDS compared to standard sedation methods. This research may help us understand better sedation options for these vulnerable patients.

Patients at Risk of Acute Respiratory Distress Syndrome>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesInternal MedicineOtolaryngologyPulmonology

Brain Aneurysms: Acetylsalicylic Acid Study

We are studying whether acetylsalicylic acid can lower the risk of stroke and improve cognitive function in patients undergoing treatment for unruptured brain aneurysms. This trial compares ASA with a placebo to assess its safety and effectiveness.

Unruptured Cerebral Aneurysm>2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesPartially RemoteNeurology

Labor Induction: Oxytocin vs. Prostaglandins

We are studying whether oxytocin is as safe as prostaglandins for inducing labor in women with an unfavorable cervix. This trial will help us understand the risks and benefits of both methods.

Labor Induction>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesGynecology and Obstetrics

Metastatic Colorectal Cancer: Choosing Chemotherapy

We are exploring a new approach to select between two chemotherapy options for patients with metastatic colorectal cancer. This study will help us understand how well these treatments work and their potential side effects.

MSS/pMMR Metastatic Colorectal Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

CAR T Cell Therapy for Severe Autoimmune Diseases

We are testing a new treatment using engineered immune cells for people with severe autoimmune diseases that haven't improved with standard therapies. This study aims to see if this approach can help manage their condition.

Idiopathic Inflammatory MyopathySystemic Lupus ErythematosusRheumatoid Arthritis>2 yearsSafety phase (I)Rheumatology

Tacrolimus Monotherapy for Elderly Kidney Transplant Recipients

We are studying whether using tacrolimus alone can reduce infection risks and improve quality of life for elderly patients after a kidney transplant. This trial compares it to the standard triple medication regimen.

Kidney Transplant Complications>2 yearsMonitoring phase (IV)Post-Trial Drug AccessNo PlaceboStandard MedicinesInternal MedicineNephrology

Pancreatic Head Cancer: Neoadjuvant Chemotherapy Study

We are exploring whether giving chemotherapy before surgery helps improve survival for patients with resectable pancreatic head cancer compared to surgery alone. This study aims to find better treatment strategies to reduce early mortality.

Resectable Pancreatic Head Cancer>2 yearsEfficacy phase (II)11-15 visitsNo PlaceboStandard MedicinesOncology

Cardiac Surgery: Angiotensin II vs. Noradrenaline

We are studying whether angiotensin II can better prevent kidney injury compared to noradrenaline in patients undergoing cardiac surgery. This research may help improve kidney health outcomes after surgery.

Acute Kidney Injury>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboInvestigational MedicinesPartially RemoteCardiologyInternal MedicineNephrology

Crohn's Disease: New Cellular Treatment for Fistulas

We are studying a new injection of fat-derived cells for people with complex perianal Crohn's fistulas. The goal is to see if this treatment helps heal fistulas better than a placebo.

Crohn's Disease>2 yearsEfficacy phase (II)≤5 visitsInvestigational MedicinesCost ReimbursementGastroenterologyInternal Medicine

Sacubitril/Valsartan for Heart Protection in Breast Cancer Treatment

We are studying whether sacubitril/valsartan can help prevent heart damage in women receiving systemic treatment for breast cancer. This trial aims to understand its potential benefits in protecting heart function during therapy.

Heart Failure>2 yearsConfirmation phase (III)Investigational MedicinesCardiologyOncology

Gastric Cancer: Personalized Immunotherapy Study

We are exploring new personalized immunotherapy treatments for patients with advanced gastric cancer. The goal is to see if these targeted therapies can improve outcomes for those with recurrent or metastatic disease.

Metastatic Gastric Adenocarcinoma>2 yearsEfficacy phase (II)Oncology

High-Risk Melanoma: Neoadjuvant Pembrolizumab Study

We are studying the effects of pembrolizumab in patients with high-risk melanoma who have no signs of spread. The goal is to see if this treatment can improve outcomes before surgery.

Melanoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesDermatologyOncology

Prostate Cancer: Atorvastatin Study

We are investigating whether atorvastatin can help delay prostate cancer progression in men receiving androgen deprivation therapy. This study aims to see if it can prevent the cancer from becoming resistant to treatment.

Metastatic Prostate Cancer>2 yearsConfirmation phase (III)Post-Trial Drug AccessStandard MedicinesOncologyUrology

Soft Tissue Sarcoma: Pembrolizumab with Radiotherapy

We are studying whether adding pembrolizumab to radiotherapy before and after surgery helps patients with high-risk localized soft tissue sarcoma live longer without disease recurrence. This trial compares this approach to standard treatment with radiotherapy and surgery alone.

High-Risk Soft Tissue Sarcoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncologyOrthopedics and Traumatology