Search Clinical Trials in the European Union

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141-160 of 240 trials

Influenza Vaccination: Antibody Responses Study

We are investigating how intranasal and intramuscular flu vaccines affect antibody levels in the nose. This research may help improve future vaccination methods.

Healthy Participants≤3 monthsMonitoring phase (IV)6-10 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteInfectious DiseasesPulmonology

Clear Cell Renal Cell Carcinoma: PET Scan Comparison

We are comparing two different PET scans to see which one detects tumors better in patients with clear cell renal cell carcinoma. This study may help improve diagnosis for those suspected of having this type of cancer.

Metastatic Renal Cell Carcinoma≤3 monthsConfirmation phase (III)≤5 visitsNo PlaceboInvestigational MedicinesInternal MedicineOncology

Vaginal Atrophy: New Estriol Vaginal Ring

We are testing a new vaginal ring that releases estriol to see if it improves vaginal health in postmenopausal women. The study will measure changes in vaginal tissue and pH after treatment.

Vulvovaginal Atrophy≤3 monthsEfficacy phase (II)≤5 visitsInvestigational MedicinesEndocrinologyGynecology and Obstetrics

Severe Vitamin D Deficiency: New Treatment Study

We are investigating a new treatment for people with severe vitamin D deficiency to see if it effectively raises vitamin D levels compared to another option. The study will also look at safety and patient satisfaction.

Severe Vitamin D Deficiency≤3 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesEndocrinologyInternal Medicine

Vaborem® for Serious Infections in Children

We are studying how Vaborem® is processed in the body and its safety in children with suspected or confirmed Gram-negative infections. This trial includes kids from birth to under 18 years old.

Acute Pyelonephritis≤3 monthsEfficacy phase (II)≤5 visitsNo PlaceboInvestigational MedicinesPartially RemoteInfectious DiseasesPediatrics

Kidney Health After Liver Transplant: Human Albumin Study

We are investigating whether higher doses of human albumin can help reduce kidney problems after liver transplantation. This study looks at various recovery aspects, including hospital stay and potential complications.

Liver Transplantation≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesHepatologyNephrology

Vitamin D for Low Testosterone in Men with Type 2 Diabetes

We are studying whether vitamin D supplements can help increase testosterone levels in men with type 2 diabetes. This trial compares the effects of vitamin D to a placebo.

Type 2 Diabetes≤3 monthsEfficacy phase (II)≤5 visitsPost-Trial Drug AccessStandard MedicinesEndocrinologyInternal Medicine

Irritable Bowel Syndrome: MYRRHINIL-INTEST®

We are investigating whether MYRRHINIL-INTEST® is effective and safe for people with diarrhoea-dominant and mixed-type irritable bowel syndrome. This study compares it to a placebo to see how well it works.

Diarrhea Predominant Irritable Bowel Syndrome≤3 monthsMonitoring phase (IV)≤5 visitsInvestigational MedicinesGastroenterologyInternal Medicine

Preventing Pancreatic Fistulas: Botulinum Toxin Injection Study

We are studying whether botulinum toxin injections can help prevent complications after pancreatic surgery in patients undergoing distal pancreatectomy. This trial aims to improve recovery and reduce the risk of serious postoperative issues.

Pancreatic Fistula≤3 monthsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteGastroenterologyInternal Medicine

Cancer Pain Management: Paracetamol with Opioids

We are studying whether stopping paracetamol affects pain control in patients using strong opioids for cancer-related pain. We also want to see if this change impacts side effects and overall patient satisfaction.

Metastatic Cancer≤3 monthsConfirmation phase (III)≤5 visitsStandard MedicinesInternal MedicineOncology

Breast Cancer: Nivolumab and Novel Immunotherapies

We are studying whether nivolumab, alone or with other treatments, can help achieve a complete response in early breast cancer patients before surgery. This trial also looks at safety and how well the treatment works.

Breast Cancer≤3 monthsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Exercise and Statin Use in Advanced Cancer Treatment

We are studying whether supervised exercise and atorvastatin can improve cancer treatment outcomes for patients with advanced breast, renal, ovarian, and prostate cancers. We also want to understand how these interventions affect patients' quality of life and experiences during treatment.

Metastatic Breast, Ovarian, Prostate, and Kidney Cancer≤3 monthsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesCost ReimbursementGynecology and ObstetricsOncologyUrology

Advanced Pancreatic Cancer: Gemcitabine and Nab-Paclitaxel Study

We are studying whether switching to a new treatment after initial chemotherapy helps patients with advanced pancreatic cancer live longer and feel better compared to continuing their current treatment.

Advanced Pancreatic Cancer≤3 monthsConfirmation phase (III)No PlaceboStandard MedicinesOncology

New Method for Umbilical Vein Catheterization in Newborns

We are studying a new technique for umbilical vein catheterization to see if it helps newborns in circulatory arrest receive faster and more effective resuscitation. This trial compares the new method with standard practices in the delivery room.

Cardiorespiratory Arrest at Birth in Full-Term Newborns≤3 monthsEfficacy phase (II)Confirmation phase (III)No PlaceboStandard MedicinesInternal MedicinePediatrics

Tranexamic Acid for Reducing Blood Loss in Cesarean Deliveries with Placenta Previa

We are studying whether a low dose of tranexamic acid can help women with placenta previa experience less blood loss during cesarean delivery. This trial aims to improve safety and outcomes for mothers and their babies.

Placenta PreviaPostpartum Hemorrhage≤3 monthsConfirmation phase (III)Standard MedicinesGynecology and ObstetricsHematology

Congenital Hyperinsulinism: HM15136 Treatment Study

We are evaluating a new treatment for children with congenital hyperinsulinism to see if it is safe and helps reduce low blood sugar events. This study includes children aged 2 years and older.

Congenital Hyperinsulinism≤3 monthsEfficacy phase (II)11-15 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesCost ReimbursementEndocrinologyPediatrics

Schizophrenia: Biomarkers for Clozapine Response

We are investigating whether specific biomarkers can help predict how well individuals with schizophrenia respond to clozapine. This research may lead to more tailored treatments for those who need them.

Schizophrenia≤3 monthsMonitoring phase (IV)11-15 visitsNo PlaceboStandard MedicinesNeurologyPsychiatry

Mucositis in Metastatic Renal Cell Carcinoma: Folic Acid Supplement Study

We are studying whether a folic acid supplement can help reduce mucositis in patients with metastatic renal cell carcinoma receiving targeted therapy. This trial will also assess the impact on quality of life and treatment side effects.

Metastatic Renal Cell Carcinoma≤3 monthsEfficacy phase (II)≤5 visitsStandard MedicinesInternal MedicineOncology

OCTAPLEX for Major Bleeding in Patients on Blood Thinners

We are studying whether a higher dose of OCTAPLEX can effectively stop major bleeding in patients taking direct oral anticoagulants. The trial also looks at the safety of this treatment during emergencies.

Coagulation DisorderAcute Major Bleeding with DOAC Therapy≤3 monthsConfirmation phase (III)No PlaceboStandard MedicinesHematology

Neuroblastoma: 177Lu-DOTATATE Therapy for Children

We are evaluating a new radioactive treatment for children with refractory or recurrent neuroblastoma. The study aims to find the safest dose and assess how well the treatment works.

Recurrent or Refractory Neuroblastoma≤3 monthsSafety phase (I)No PlaceboInvestigational MedicinesOncologyPediatrics