Search Clinical Trials in the European Union

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1701-1720 of 1,738 trials

Ulcerative Colitis: RO7837195 Treatment Study

We are testing a new medication, RO7837195, for people with moderately to severely active ulcerative colitis. The study aims to see if it can help induce remission and how safe it is compared to a placebo.

Ulcerative Colitis>2 yearsEfficacy phase (II)Investigational MedicinesCost ReimbursementPartially RemoteGastroenterologyInternal Medicine

Cemiplimab and Imiquimod for High-Risk Basal Cell Carcinoma

We are studying a combination of cemiplimab, imiquimod, and laser therapy for patients with high-risk cutaneous basal cell carcinoma. The goal is to evaluate safety and how well this treatment works before surgery.

Skin Cancer (Basal Cell Carcinoma)>2 yearsSafety phase (I)Efficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesDermatologyOncology

Ulcerative Colitis: SAR441566 Study

We are investigating the effects of SAR441566 in adults with moderate-to-severe ulcerative colitis. The study aims to see if different doses can help achieve remission and improve overall health.

Ulcerative Colitis1-2 yearsEfficacy phase (II)16-20 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteGastroenterologyInternal Medicine

Advanced Colorectal Cancer: OMTX705 Combination Therapy

We are studying a new drug, OMTX705, combined with regorafenib and tislelizumab for patients with advanced colorectal cancer. The goal is to evaluate its safety and effectiveness in those who have not responded to previous treatments.

Metastatic Colorectal Cancer1-2 yearsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesOncology

Rapamycin Cream for Port Wine Stains

We are studying whether two strengths of rapamycin cream can improve the appearance of port wine stains in individuals after laser therapy. Participants will compare the effects of the cream to a placebo over several weeks.

Port Wine Stain≤3 monthsEfficacy phase (II)≤5 visitsStandard MedicinesDermatology

Postoperative Pain Relief: High Dose Dexamethasone for Lung Surgery

We are studying whether a higher dose of Dexamethasone can reduce pain after video-assisted thoracoscopic surgery in patients who typically experience high pain. This trial compares a high dose to a standard lower dose to find the best pain management approach.

Lung Cancer≤3 monthsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesInternal MedicineOrthopedics and TraumatologyOtolaryngologyPulmonology

Botulinum Toxin Treatment: Patient Satisfaction Study

We are examining how satisfied patients are with split doses of botulinum toxin compared to a control group. The study also looks at the safety of this treatment over time.

Frown Lines6-12 monthsEfficacy phase (II)Confirmation phase (III)≤5 visitsInvestigational MedicinesDermatology

Learning Dynamics: Atomoxetine Study

We are investigating how a low dose of atomoxetine affects learning and emotional states in healthy adults. This study aims to understand its impact on learning tasks and emotional well-being.

Healthy Participants>2 yearsEfficacy phase (II)≤5 visitsStandard MedicinesPsychiatry

Idiopathic Hypersomnia: ALKS 2680 Study

We are evaluating a new medication, ALKS 2680, for individuals with Idiopathic Hypersomnia to see if it helps reduce excessive daytime sleepiness and is safe to use.

Idiopathic Hypersomnia3-6 monthsEfficacy phase (II)6-10 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteInternal MedicineNeurology

Graves' Disease: Rilzabrutinib Study

We are investigating whether rilzabrutinib can help reduce thyroid activity in adults with Graves' disease. The study also aims to evaluate the safety of this new treatment.

Graves' Disease3-6 monthsEfficacy phase (II)11-15 visitsNo PlaceboInvestigational MedicinesPartially RemoteEndocrinologyInternal Medicine

Pomalidomide for Chronic Hepatitis B Infection

We are studying the safety of pomalidomide in people with chronic hepatitis B. The trial also looks at how this medication may improve immune responses and liver health.

Hepatitis B Virus Infection6-12 monthsSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesHepatologyInfectious Diseases

Darolutamide and Bipolar Androgen Therapy for Advanced Prostate Cancer

We are studying whether combining Darolutamide with bipolar androgen therapy improves survival and quality of life for men with metastatic castration-resistant prostate cancer compared to standard treatments.

Metastatic Castration-Resistant Prostate Cancer>2 yearsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteOncologyUrology

Tulisokibart for Ankylosing Spondylitis

We are studying a new medication, tulisokibart, to see if it helps people with ankylosing spondylitis feel better compared to a placebo. The trial will assess improvements in pain, function, and overall quality of life.

Ankylosing Spondylitis>2 yearsEfficacy phase (II)11-15 visitsPost-Trial Drug AccessInvestigational MedicinesRheumatology

Zelenectide Pevedotin for Advanced Non-small Cell Lung Cancer

We are studying a new treatment for patients with advanced or metastatic non-small cell lung cancer that has NECTIN4 amplification. The goal is to see how well it works and how safe it is for those who have already been treated.

Advanced Non-small Cell Lung Cancer1-2 yearsEfficacy phase (II)11-15 visitsNo PlaceboInvestigational MedicinesOncology

Ovarian Cancer: COM701 Treatment Study

We are testing the safety and effectiveness of COM701 for patients with relapsed platinum-sensitive ovarian cancer. The study aims to see if it can help patients maintain their health without cancer progression.

Ovarian CancerRecurrent Ovarian Cancer1-2 yearsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessInvestigational MedicinesPartially RemoteGynecology and ObstetricsOncology

Non-Small Cell Lung Cancer: RMC-9805 and RMC-6236 Study

We are studying a new treatment combination for patients with RAS G12D-mutant non-small cell lung cancer. The trial will evaluate the safety and effectiveness of these drugs alongside other anticancer therapies.

Non-small Cell Lung Cancer3-6 monthsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementOncologyPulmonology

Mantle Cell Lymphoma: Acalabrutinib with R-CHOP

We are studying the combination of acalabrutinib and R-CHOP for patients with previously untreated mantle cell lymphoma. The goal is to see if this combination improves treatment response and is safe.

Mantle Cell Lymphoma>2 yearsEfficacy phase (II)16-20 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesHematologyOncology

Chronic Subdural Hematoma: Timing of Anticoagulation

We are studying whether starting blood-thinning medication early or later helps patients with atrial fibrillation recover better after surgery for chronic subdural hematoma. This research looks at potential risks and overall health outcomes.

Chronic Subdural HematomaAtrial Fibrillation3-6 monthsEfficacy phase (II)Confirmation phase (III)No PlaceboStandard MedicinesPartially RemoteCardiologyInternal MedicineNeurology

Immunotherapy for Metastatic Colorectal and Prostate Cancer

We are studying a new treatment using patients' own immune cells to see if it is safe and tolerable for those with advanced colorectal or prostate cancer. The trial will help us understand how well this therapy works in these patients.

Locally Advanced or Metastatic Prostate CancerMetastatic Colorectal Cancer>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboStandard MedicinesPartially RemoteGastroenterologyOncologyUrology

Birth Control Study: Levonorgestrel Tablet

We are investigating whether the Levonorgestrel tablet can still prevent ovulation despite planned delays in taking the pill. This study is for individuals interested in understanding the reliability of this contraceptive method.

Ovulation Inhibition6-12 monthsEfficacy phase (II)No PlaceboStandard MedicinesGynecology and Obstetrics