Search Clinical Trials in the European Union

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1581-1600 of 2,251 trials

Chronic Lymphocytic Leukemia: Ibrutinib and Obinutuzumab Treatment

We are studying a combination of ibrutinib and obinutuzumab for newly diagnosed patients with Chronic Lymphocytic Leukemia. The aim is to see if this treatment effectively reduces cancer cells in the bone marrow.

Chronic Lymphocytic Leukemia (CLL)>2 yearsEfficacy phase (II)>20 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesOncology

Advanced Solid Tumors: OSE-279 Treatment Study

We are investigating a new monoclonal antibody, OSE-279, for patients with advanced solid tumors or lymphomas. The study aims to find the best dose and evaluate its safety and effectiveness compared to existing treatments.

Stage IV Non-Small Cell Lung CancerAdvanced Solid TumorsLymphoma1-2 yearsSafety phase (I)Efficacy phase (II)11-15 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementOncology

Rectal Cancer: Ferumoxtran-10 MRI Study

We are testing a new MRI method to see if it better identifies lymph node involvement in patients with newly diagnosed rectal cancer. This may help doctors plan more effective treatments.

Rectal CancerMesorectal Lymph Node Metastases>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesOncologyOtolaryngology

Severe Asthma: Predicting Response to Benralizumab

We are studying whether early blood tests can predict how well severe asthma patients respond to Benralizumab treatment. This may help identify those who are likely to experience fewer asthma attacks.

Severe Asthma>2 yearsMonitoring phase (IV)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteAllergologyPulmonology

Unilateral Retinoblastoma: Adjuvant Treatment Study

We are studying additional treatments for patients with unilateral retinoblastoma after eye removal. The goal is to understand how these treatments affect recovery and any potential side effects.

Retinoblastoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncologyOphthalmology

CRN04894 for Hormonal Imbalance

We are studying the safety and effectiveness of CRN04894 in participants with hormonal imbalances. The goal is to see how it affects hormone levels and overall health.

Congenital Adrenal HyperplasiaEfficacy phase (II)6-10 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesPartially RemoteEndocrinologyPediatrics

Preventing Abscesses After Appendicitis Surgery: ALPACA Trial

We are studying if a special antibiotic wash during surgery can lower the risk of abscesses in patients with complicated appendicitis. This trial aims to improve recovery and reduce complications after surgery.

Appendicitis>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesGastroenterologyInfectious DiseasesOrthopedics and Traumatology

Scoliosis Surgery: Pooled Plasma vs. Crystalloid

We are studying whether pooled human plasma can reduce blood loss during spinal fusion surgery in children with scoliosis compared to a standard fluid. This trial aims to improve fluid management during surgery.

Neuromuscular ScoliosisAdolescent Idiopathic Scoliosis>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesOrthopedics and TraumatologyPediatrics

Glioblastoma: Bevacizumab with Radiochemotherapy

We are studying a new treatment approach for patients with newly diagnosed glioblastoma to see if it improves survival and quality of life. The trial also evaluates safety and cognitive effects.

Glioblastoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Advanced Soft-Tissue Sarcomas: Next-Generation Sequencing Study

We are exploring whether high-throughput molecular analysis can help guide treatment for patients with advanced soft-tissue sarcomas. This study will compare treatment outcomes for those receiving NGS-guided therapy versus standard care.

Unresectable Soft-Tissue Sarcoma>2 yearsConfirmation phase (III)No PlaceboInvestigational MedicinesOncology

Head and Neck Cancer: Shortened Chemotherapy with Pembrolizumab

We are studying a shorter chemotherapy treatment combined with Pembrolizumab for patients with PD-L1-positive recurrent or metastatic head and neck cancer. The goal is to see if this approach is effective and safe compared to standard treatments.

Head and Neck Squamous Cell Carcinoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

MDS and AML: Venetoclax with Azacitidine

We are studying a new treatment combining venetoclax and azacitidine with donor lymphocyte infusion for patients with MDS or AML who have relapsed after a stem cell transplant. The goal is to assess its safety and effectiveness.

Acute Myeloid LeukemiaMyelodysplastic Syndromes>2 yearsSafety phase (I)Efficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesHematologyOncology

Gastric Cancer: IP Paclitaxel and Systemic Therapy Study

We are comparing the effects of intraperitoneal paclitaxel combined with standard therapy against standard therapy alone in patients with gastric cancer and peritoneal metastases. This study aims to see if the combination improves survival and quality of life.

Metastatic Gastric Cancer1-2 yearsConfirmation phase (III)No PlaceboStandard MedicinesOncology

Pemphigus: Personalized Treatment Strategy vs. Standard Care

We are studying whether a personalized treatment plan based on specific blood markers can reduce relapse rates in pemphigus patients compared to standard treatment with rituximab and corticosteroids.

Pemphigus Diseases>2 yearsMonitoring phase (IV)>20 visitsNo PlaceboStandard MedicinesDermatologyRheumatology

Acute Hyperkalemia: Comparing Treatments

We are studying whether insulin/dextrose infusion, nebulized salbutamol, or their combination is more effective in lowering high potassium levels in emergency patients. This research aims to find the best first-line treatment for acute hyperkalemia.

High Potassium Levels>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesEndocrinologyInternal Medicine

Short Course Antibiotics for Gram-Negative Bacteremia

We are studying whether a 5-day antibiotic treatment is as effective and safe as longer treatments for hospitalized adults with Gram-negative bacteremia from urinary tract infections.

Gram-negative Bacteremia3-6 monthsMonitoring phase (IV)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteInfectious DiseasesInternal Medicine

Type 1 Diabetes: Semaglutide Treatment Study

We are investigating whether adding semaglutide to standard treatment helps people with type 1 diabetes and 'double diabetes' better control their blood sugar and weight. This study will also look at insulin use and potential side effects.

Double Diabetes6-12 monthsConfirmation phase (III)No PlaceboStandard MedicinesPartially RemoteDiabetologyEndocrinology

Hepatocellular Carcinoma: Durvalumab and Tremelimumab Study

We are comparing two treatment methods for patients with liver cancer to see if combining immune therapy with chemotherapy improves outcomes. The study will assess effectiveness, safety, and quality of life.

Hepatocellular Carcinoma (HCC)>2 yearsEfficacy phase (II)Confirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesHepatologyOncology

Emergency Tracheal Intubation: New Optimization Strategy

We are studying a new method for emergency tracheal intubation to see if it reduces complications in adult patients. This approach combines medication and ventilation techniques to improve patient safety during emergencies.

Respiratory Distress>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard Medicines

Preventing Pancreatic Fistulas: Botulinum Toxin Injection Study

We are studying whether botulinum toxin injections can help prevent complications after pancreatic surgery in patients undergoing distal pancreatectomy. This trial aims to improve recovery and reduce the risk of serious postoperative issues.

Pancreatic Fistula≤3 monthsConfirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesPartially RemoteGastroenterologyInternal Medicine