Search Clinical Trials in the European Union

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941-960 of 2,120 trials

Diffuse Large B-cell Lymphoma: Loncastuximab and Epcoritamab Study

We are studying a combination of two medications for patients with relapsed or refractory diffuse large B-cell lymphoma. The goal is to see how well this treatment works and its safety compared to existing options.

Diffuse Large B-Cell Lymphoma (DLBCL)Follicular Lymphoma (FL) Grade 3BHigh-Grade B-Cell Lymphoma (HGBL)>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesHematologyOncology

Severe von Willebrand Disease: Vonicog Alfa Prophylaxis

We are studying whether vonicog alfa can help prevent bleeding episodes in children with severe von Willebrand disease. The trial will also look at the safety of this treatment over time.

Von Willebrand Disease1-2 yearsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteHematology

Non-Small Cell Lung Cancer: Osimertinib with Datopotamab Deruxtecan

We are studying the safety and effectiveness of combining osimertinib with datopotamab deruxtecan in patients with advanced non-small cell lung cancer that has an EGFR mutation. This trial aims to see if the combination works better than osimertinib alone.

Non-Squamous Non-Small Cell Lung Cancer>2 yearsConfirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteOncology

Refractory Generalized Myasthenia Gravis: KYV-101 Therapy

We are studying a new CAR T-cell therapy for individuals with refractory generalized myasthenia gravis. The goal is to evaluate its safety and effectiveness in improving muscle strength.

Myasthenia GravisRefractory Generalized Myasthenia Gravis>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesInfectious DiseasesNeurology

Lower Limb Trauma: Rivaroxaban vs. Heparin

We are studying whether Rivaroxaban is as effective as low-molecular weight heparin in preventing blood clots in patients with lower limb injuries. This trial is for those at high risk of complications while in a cast or brace.

Lower Limb Trauma Requiring Immobilization≤3 monthsConfirmation phase (III)No PlaceboInvestigational MedicinesCardiologyOrthopedics and Traumatology

Stroke Treatment: Thrombolysis for Patients on Factor Xa Inhibitors

We are studying whether intravenous thrombolysis can improve recovery in stroke patients who have recently taken Factor Xa inhibitors. This trial compares the effects of this treatment to standard care options.

Acute Ischemic Stroke>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesCost ReimbursementPartially RemoteInternal MedicineNeurology

Mantle Cell Lymphoma: Zanubrutinib with Rituximab

We are comparing a new treatment combining Zanubrutinib and Rituximab to standard therapy for patients with untreated mantle cell lymphoma who cannot have a stem cell transplant. The goal is to see which treatment works better and is safer.

Mantle Cell Lymphoma>2 yearsEfficacy phase (II)Confirmation phase (III)>20 visitsNo PlaceboStandard MedicinesCost ReimbursementHematologyOncology

Difelikefalin for Itching in Adolescents on Hemodialysis

We are studying whether difelikefalin is safe for adolescents aged 12 to 17 who have moderate-to-severe itching related to long-term kidney disease. This trial aims to help improve care for young patients undergoing hemodialysis.

Generalized ItchingChronic Kidney Diseases3-6 monthsEfficacy phase (II)>20 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteDermatologyNephrologyPediatrics

Pegozafermin for Metabolic Dysfunction-Associated Steatohepatitis (MASH)

We are studying whether pegozafermin can improve liver health in people with MASH and fibrosis compared to a placebo. This trial will help us understand its safety and effectiveness over time.

Nonalcoholic Fatty Liver Disease>2 yearsConfirmation phase (III)11-15 visitsPost-Trial Drug AccessInvestigational MedicinesCost ReimbursementPartially RemoteEndocrinologyHepatology

Oocyte Cryopreservation: Random Start Ovarian Stimulation

We are comparing a new method of ovarian stimulation with a traditional approach for women planning to freeze their eggs. This study aims to determine if the new method is equally effective.

Prevention of Female Infertility≤3 monthsMonitoring phase (IV)≤5 visitsNo PlaceboInvestigational MedicinesEndocrinologyGynecology and Obstetrics

Kidney Transplant: BIVV020 for Rejection Prevention and Treatment

We are studying BIVV020 to see if it can help prevent or treat antibody-mediated rejection in adults who have received a kidney transplant. This trial will assess its safety and how well it works compared to current treatments.

Transplant Rejection1-2 yearsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesCost ReimbursementHematologyInfectious DiseasesInternal MedicineOncology

Chemotherapy Dose Adjustment for DPD-Deficient Gastrointestinal Cancer Patients

We are studying how to safely adjust chemotherapy doses for patients with gastrointestinal cancers who lack a specific liver enzyme. This may help reduce severe side effects during treatment.

Gastrointestinal Cancer Patients Starting Chemotherapy>2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesGastroenterologyOncology

Tranexamic Acid for Reducing Blood Transfusions in Abdominal Surgery

We are studying whether Tranexamic Acid can lower blood loss and the need for blood transfusions during major abdominal surgeries. This trial also examines safety and recovery outcomes for patients.

Intraoperative Bleeding1-2 yearsMonitoring phase (IV)≤5 visitsStandard MedicinesHematologyOrthopedics and Traumatology

Melanoma Treatment: Short vs. Long Immunotherapy

We are studying whether 6 months of immunotherapy after surgery is as effective as 12 months for patients with high-risk malignant melanoma. This could help determine the best treatment duration for better outcomes.

Skin Cancer (Melanoma)Confirmation phase (III)Post-Trial Drug AccessNo PlaceboStandard MedicinesDermatologyOncology

Chronic Low Back Pain: Stem Cell Injection Study

We are investigating whether injecting stem cells into the spine can help reduce pain and improve function in people with chronic low back pain from degenerative disc disease. This trial is for those who haven't responded to traditional treatments.

Degenerative Disc Disease>2 yearsEfficacy phase (II)Confirmation phase (III)6-10 visitsInvestigational MedicinesInternal MedicineOrthopedics and Traumatology

Metastatic Pancreatic Cancer: Dostarlimab with mFOLFIRINOX

We are studying a new treatment combining Dostarlimab, vitamin D3, and standard chemotherapy for patients with untreated metastatic pancreatic cancer. The goal is to see if this combination can effectively fight the cancer and assess its safety.

Metastatic Pancreatic Cancer>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesOncology

Inebilizumab for Children with Neuromyelitis Optica Spectrum Disorder

We are studying how the medication inebilizumab affects children and adolescents with NMOSD. The trial will help us learn about its safety and how it impacts their health and daily life.

Neuromyelitis Optica Spectrum Disorder1-2 yearsEfficacy phase (II)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesNeurology

Ketamine for Reducing Opioid Use in Severe Trauma

We are studying whether low doses of ketamine can help reduce the need for morphine in patients with severe trauma. This trial will also look at pain control and any side effects during treatment.

Traumatism>2 yearsConfirmation phase (III)Investigational MedicinesInternal MedicineOtolaryngologyPsychiatry

Mucopolysaccharidosis IIIA: Gene Therapy Study

We are testing a new gene therapy called UX111 for individuals with Mucopolysaccharidosis IIIA. The goal is to see if it is safe and effective in treating this condition.

Mucopolysaccharidosis III>2 yearsSafety phase (I)Efficacy phase (II)11-15 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteHematologyInternal MedicineNeurologyPediatrics

Meniscal Pain Relief: Betamethasone Infiltration Study

We are testing whether ultrasound-guided betamethasone injections can reduce pain in adults with degenerative meniscal injuries. This study compares the treatment to a placebo to assess its effectiveness and safety.

Meniscal Pain3-6 monthsConfirmation phase (III)≤5 visitsStandard MedicinesPartially RemoteInternal MedicineOrthopedics and Traumatology