Search Clinical Trials in the European Union

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1301-1320 of 1,694 trials

Rapamycin for Drug-Resistant Epilepsy in Children

We are studying the safety and effectiveness of rapamycin for children with drug-resistant epilepsy caused by rare central nervous system diseases. This trial aims to find better treatment options for these challenging conditions.

Epilepsy and Related Disorders>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesNeurology

High-Grade Glioma in Children: Rapamycin Study

We are evaluating the safety and effectiveness of rapamycin for treating high-grade gliomas in children. This study aims to understand how well it works and if genetic factors play a role in treatment response.

High Grade Glioma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncologyPediatrics

DIPG Treatment: Targeted Drug Study for Children

We are testing how well certain drugs work for children with diffuse intrinsic pontine glioma (DIPG) based on their tumor's genetic makeup. The goal is to find safer and more effective treatments tailored to individual patients.

Diffuse Intrinsic Pontine Glioma>2 yearsEfficacy phase (II)No PlaceboInvestigational MedicinesNeurologyOncologyPediatrics

Myelofibrosis: Study of Pacritinib vs. Standard Treatment

We are investigating whether pacritinib can better reduce spleen size and improve symptoms in patients with myelofibrosis. This trial is for those with severe low platelet counts and compares pacritinib to physician's choice of therapy.

Post-Polycythaemia Vera MyelofibrosisPrimary MyelofibrosisPost-Essential Thrombocythaemia Myelofibrosis3-6 monthsConfirmation phase (III)6-10 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementHematologyOncology

Hidradenitis Suppurativa: Brensocatib Study

We are testing a new medication, brensocatib, for adults with moderate to severe hidradenitis suppurativa. The study aims to see if it is more effective than a placebo in improving symptoms.

Hidradenitis Suppurativa1-2 yearsEfficacy phase (II)16-20 visitsInvestigational MedicinesCost ReimbursementPartially RemoteDermatology

Nevoid Basal Cell Carcinoma Syndrome: Sonidegib Treatment Study

We are studying the effects of Sonidegib on patients with Nevoid Basal Cell Carcinoma Syndrome and sporadic basal cell carcinoma. The trial will assess treatment effectiveness, safety, and quality of life improvements.

Nevoid Basal Cell Carcinoma Syndrome6-12 monthsEfficacy phase (II)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesOncology

Out-of-Hospital Cardiac Arrest: DANOHCA Study

We are testing different treatments, including medications and positioning, for patients who have had a cardiac arrest outside the hospital. Our goal is to see which methods may improve survival and recovery.

Cardiac Arrest>2 yearsConfirmation phase (III)Standard MedicinesCardiologyInternal Medicine

Cardiac Surgery: Dexamethasone and Olanzapine Study

We are investigating whether dexamethasone and olanzapine improve recovery for adults undergoing heart surgery. The study also looks at different management techniques to enhance patient outcomes after surgery.

Ischemic Heart DiseaseHeart Valve Surgery>2 yearsConfirmation phase (III)Standard MedicinesCardiologyInternal Medicine

Post-Surgical Hypoparathyroidism: Indapamide Treatment

We are studying whether daily Indapamide can help manage calcium levels in patients with post-surgical hypoparathyroidism. This trial will also look at the safety of the treatment and its effects on urinary calcium excretion.

Hypoparathyroidism≤3 monthsMonitoring phase (IV)6-10 visitsStandard MedicinesCost ReimbursementEndocrinologyInternal Medicine

Multiple Myeloma: Belantamab Mafodotin vs. Daratumumab

We are studying a new treatment combination for people with newly diagnosed multiple myeloma who cannot have stem cell transplants. The goal is to see if it works better and is safer than the current standard treatment.

Multiple MyelomaConfirmation phase (III)11-15 visitsPost-Trial Drug AccessNo PlaceboInvestigational MedicinesCost ReimbursementPartially RemoteHematologyOncology

Chronic Kidney Disease: Dapagliflozin and Balcinrenone Study

We are investigating how dapagliflozin, alone or with balcinrenone, affects kidney function and fluid balance in people over 50 with chronic kidney disease. This study aims to understand the potential benefits of these treatments on energy metabolism and urine concentration.

Stage 3 Chronic Kidney Disease1-2 yearsEfficacy phase (II)Investigational MedicinesEndocrinologyNephrology

Ifinatamab Deruxtecan for Metastatic Prostate Cancer

We are studying ifinatamab deruxtecan to see if it is safe and effective for men with metastatic castration-resistant prostate cancer. This trial will help us understand how well it works compared to other treatments.

Metastatic Castrate Resistant Prostate Cancer>2 yearsSafety phase (I)Efficacy phase (II)No PlaceboInvestigational MedicinesCost ReimbursementOncology

Migraine Aura: Amiloride Study

We are investigating whether amiloride can help prevent migraine aura and headaches in people who experience these symptoms. The study will also assess the safety of this medication.

Migraine Aura6-12 monthsEfficacy phase (II)Confirmation phase (III)Standard MedicinesInternal MedicineNeurology

Chronic Myeloid Leukemia: Asciminib Treatment Study

We are studying Asciminib for patients with Chronic Myeloid Leukemia who have the T315I mutation and have not responded to ponatinib. The trial aims to see how well it works and how safe it is.

Chronic Myeloid Leukemia>2 yearsEfficacy phase (II)≤5 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesPartially RemoteOncology

Hydroxychloroquine for Early Systemic Sclerosis

We are studying whether adding hydroxychloroquine to standard treatments helps improve symptoms in people with early systemic sclerosis. The trial will assess its safety and effectiveness compared to a placebo.

Systemic Sclerosis1-2 yearsConfirmation phase (III)≤5 visitsStandard MedicinesInternal MedicineRheumatology

Serotonin and Decision-Making: A Behavioral Study

We are investigating how serotonin influences learning and decision-making in individuals. The study also looks at how personal traits like perfectionism and impulsivity relate to these behaviors.

Healthy Participants≤3 monthsMonitoring phase (IV)≤5 visitsStandard MedicinesPsychiatry

Severe Influenza: Early Oseltamivir Carboxylate Levels

We are studying how low levels of oseltamivir carboxylate in critically ill patients with severe influenza affect their recovery and survival. This research may help improve treatment for patients in intensive care.

Severe Influenza Infection>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesInfectious DiseasesInternal Medicine

Advanced Ovarian Cancer: Niraparib Alone vs. Niraparib with Bevacizumab

We are studying whether combining Niraparib with Bevacizumab improves outcomes for patients receiving chemotherapy for advanced ovarian cancer. This trial aims to see if the combination treatment helps patients live longer without their cancer progressing.

Ovarian CancerPeritoneal CarcinomaFallopian Tube CancerConfirmation phase (III)16-20 visitsNo PlaceboStandard MedicinesOncology

Ewing Sarcoma: Comparing Chemotherapy Treatments

We are studying different chemotherapy regimens for patients with recurrent or refractory Ewing Sarcoma. Our goal is to find the most effective and patient-friendly treatment option.

Ewing's Sarcoma3-6 monthsEfficacy phase (II)Confirmation phase (III)No PlaceboStandard MedicinesOncology

Pulmonary Tuberculosis: Cysteamine Therapy Study

We are investigating the safety of cysteamine as an additional treatment for adults with pulmonary tuberculosis. This study aims to see how it affects bacterial load and immune response during standard TB therapy.

Pulmonary Tuberculosis>2 yearsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesInfectious DiseasesPulmonology