Search Clinical Trials in the European Union

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841-860 of 1,782 trials

Breast Cancer: Fezolinetant for Hot Flashes

We are studying whether fezolinetant can help reduce hot flashes in women with hormone receptor-positive breast cancer receiving hormone therapy. The trial also looks at how this treatment affects quality of life and sleep.

Hot Flashes1-2 yearsConfirmation phase (III)11-15 visitsStandard MedicinesPartially RemoteEndocrinologyOncology

Dementia with Lewy Bodies: Ambroxol Study

We are investigating whether Ambroxol can improve cognitive and functional abilities in people with early Dementia with Lewy Bodies. The study also looks at its effects on sleep disturbances and other related symptoms.

Dementia with Lewy Bodies1-2 yearsEfficacy phase (II)>20 visitsPost-Trial Drug AccessStandard MedicinesNeurologyPsychiatry

Axial Spondyloarthritis and Psoriatic Arthritis: Ixekizumab Study

We are examining how ixekizumab affects inflammation in patients with axial spondyloarthritis and psoriatic arthritis. This study uses whole-body MRI to measure changes in joints and entheses.

Psoriatic ArthritisAxial Spondyloarthritis>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesOrthopedics and TraumatologyRheumatology

Stroke Treatment: Anesthesia vs. Sedation

We are comparing general anesthesia to sedation with high-flow nasal cannula for patients undergoing treatment for acute ischemic stroke. Our goal is to see which method leads to better recovery and fewer complications.

Acute Ischemic Stroke>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesNeurologyOtolaryngology

Knee Osteoarthritis: Diclofenac vs. Placebo

We are studying how diclofenac affects knee pain compared to a placebo in people with knee osteoarthritis. The trial also looks at how a special script may change patients' pain experiences.

Knee Osteoarthritis≤3 monthsMonitoring phase (IV)≤5 visitsStandard MedicinesCost ReimbursementInternal MedicineOrthopedics and Traumatology

Whipple's Procedure: Antibiotic Treatment Comparison

We are studying whether pre-emptive antibiotics can lower the risk of infections after Whipple's surgery compared to standard antibiotic treatment. This trial aims to improve recovery outcomes for patients undergoing this procedure.

Pancreatoduodenectomy with High Risk for Contaminated Bile>2 yearsConfirmation phase (III)Monitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyInfectious Diseases

Knee Surgery Pain Relief: Oral vs. IV Medications

We are comparing the effectiveness of oral pain relief to intravenous options for patients after knee arthroscopy. This study aims to see which method better manages pain and affects recovery.

Postoperative Pain Relief1-2 yearsMonitoring phase (IV)Standard MedicinesOrthopedics and TraumatologyOtolaryngology

Hyperbaric Oxygen Therapy for Sudden Hearing Loss

We are studying whether adding hyperbaric oxygen treatment to standard care improves hearing in people with sudden sensorineural hearing loss. The trial will also look at quality of life and safety of this treatment approach.

Sudden Hearing Loss3-6 monthsEfficacy phase (II)Confirmation phase (III)≤5 visitsNo PlaceboStandard MedicinesOtolaryngology

Ulcerative Colitis: CICR-NAM Treatment Study

We are testing a new oral medication for people with mild to moderately active ulcerative colitis. The goal is to see if it helps improve symptoms and overall gut health.

Ulcerative Colitis1-2 yearsEfficacy phase (II)Confirmation phase (III)6-10 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementGastroenterology

Post-Stroke Spasticity: Dry Needling vs. Botulinum Toxin

We are exploring how Dry Needling and Botulinum Toxin type A affect spasticity in the lower limbs of stroke survivors. The study will also look at safety, muscle function, and quality of life.

Spasticity after Stroke3-6 monthsEfficacy phase (II)16-20 visitsNo PlaceboStandard MedicinesNeurologyOrthopedics and Traumatology

Bladder Cancer: Mitomycin C Treatment Study

We are studying whether a new way to deliver mitomycin C before bladder surgery can lower the risk of cancer returning or worsening in patients with non-muscle invasive bladder tumors.

Non-Muscle Invasive Bladder Tumors>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesOncologyUrology

Tezepelumab for Progressive Pulmonary Fibrosis

We are studying whether Tezepelumab can help reduce symptoms and improve lung function in people with progressive pulmonary fibrosis and high eosinophil levels. This trial compares the medication to a placebo to evaluate its effectiveness.

Interstitial Pulmonary Fibrosis1-2 yearsEfficacy phase (II)6-10 visitsPost-Trial Drug AccessStandard MedicinesPartially RemotePulmonology

Neuroendocrine Neoplasms: Metronomic Temozolomide Study

We are investigating the effects of low-dose Temozolomide in patients with advanced neuroendocrine neoplasms who are not fit for traditional treatments. The goal is to see if this approach can improve survival and quality of life.

Neuroendocrine Carcinoma>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesInternal MedicineOncology

Pain Relief After Esophageal Procedure: Levobupivacaine Study

We are testing a local anesthetic to see if it helps reduce pain after endoscopic submucosal dissection for esophageal lesions. The study will also look at its safety and impact on recovery time.

Visible Esophageal Lesions (Pre-cancerous)>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterologyInternal MedicineOtolaryngology

Advanced Melanoma: Relatlimab with Nivolumab Study

We are investigating whether combining Relatlimab with Nivolumab helps people with untreated advanced melanoma live longer and have better outcomes than Nivolumab alone.

Metastatic Melanoma1-2 yearsEfficacy phase (II)Confirmation phase (III)No PlaceboStandard MedicinesPartially RemoteOncology

Hip Replacement: Antibiotic Impregnated Bone Graft Study

We are investigating whether a new antibiotic-infused bone graft can reduce the risk of infection after hip replacement surgery. This study compares it to a standard graft to see which is more effective and safe.

Prosthetic Joint Infection>2 yearsEfficacy phase (II)≤5 visitsStandard MedicinesInfectious DiseasesOrthopedics and Traumatology

Prolonged Seizures: Staccato Alprazolam Study

We are investigating whether Staccato Alprazolam is safe and effective for quickly stopping prolonged seizures in individuals aged 12 and older. The study compares its effects to a placebo to assess its benefits.

Prolonged Seizure3-6 monthsConfirmation phase (III)≤5 visitsPost-Trial Drug AccessStandard MedicinesCost ReimbursementPartially RemoteNeurology

Regorafenib for Recurrent Grade 2 and 3 Meningioma

We are studying whether Regorafenib can help patients with recurrent grade 2 and 3 meningiomas live longer without disease progression after surgery and radiotherapy. The trial also looks at overall survival, quality of life, and potential side effects.

Malignant Meningioma>2 yearsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesNeurologyOncology

Cognitive Impairment in Parkinson's: Donepezil Study

We are studying whether donepezil can improve cognitive function in people with mild cognitive impairment due to Parkinson's disease. The trial will also evaluate its effects on mental health and quality of life.

Parkinson's Disease6-12 monthsEfficacy phase (II)6-10 visitsStandard MedicinesNeurology

Diffuse Large B-Cell Lymphoma: Epcoritamab Plus Lenalidomide

We are studying whether a new combination of epcoritamab and lenalidomide can improve survival rates for adults with relapsed or refractory diffuse large B-cell lymphoma compared to standard treatments.

Relapsed or Refractory Diffuse Large B-Cell Lymphoma6-12 monthsConfirmation phase (III)11-15 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteHematologyOncology