Search Clinical Trials in the European Union

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1601-1620 of 1,782 trials

Ketamine for Treating Disorders of Consciousness After Coma

We are studying whether intravenous ketamine can help patients regain consciousness after a coma. The trial also aims to identify which patients may respond best to this treatment.

Severe Brain Injury and Disorder of Consciousness>2 yearsEfficacy phase (II)Standard MedicinesPartially RemoteNeurologyPsychiatry

Ulcerative Colitis: Tofacitinib's Impact on Blood Clotting

We are studying how tofacitinib affects blood clotting and platelet function in patients with ulcerative colitis. This trial also compares its effects to other treatments and collects samples for future research.

Ulcerative Colitis3-6 monthsMonitoring phase (IV)Post-Trial Drug AccessNo PlaceboStandard MedicinesGastroenterologyHematology

STOP-LEUKEMIA: Metformin for Blood Disorders

We are investigating whether metformin can help prevent leukemia in patients with clonal cytopenia of undetermined significance and lower-risk myelodysplastic syndromes. This study will assess the safety of metformin and explore how it may affect disease progression.

Myelodysplastic Syndromes (MDS)Clonal Cytopenia of Undetermined Significance (CCUS)1-2 yearsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementHematologyOncology

Cerebral Palsy: IncobotulinumtoxinA Treatment

We are studying the safety and effectiveness of IncobotulinumtoxinA for children with upper and lower limb spasticity due to cerebral palsy. This trial includes both new and previously treated patients to see how well the treatment works.

Muscle Spasticity1-2 yearsEfficacy phase (II)6-10 visitsNo PlaceboStandard MedicinesNeurologyPediatrics

Neovascular Age-Related Macular Degeneration: AI-Assisted Treatment

We are exploring how artificial intelligence can help improve treatment for patients with active neovascular AMD. This study aims to make the treatment process easier for patients and healthcare providers.

Neovascular Age-Related Macular Degeneration1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesOphthalmology

Immune Thrombocytopenia: Pirtobrutinib Study

We are investigating a new medication, pirtobrutinib, for adults with immune thrombocytopenia. The study aims to assess its safety and effectiveness compared to a placebo.

Immune Thrombocytopenia≤3 monthsSafety phase (I)Efficacy phase (II)11-15 visitsStandard MedicinesCost ReimbursementPartially RemoteHematology

Ischemic Stroke: Thrombolytic Therapy with rtPA

We are studying a new treatment for patients with acute ischemic stroke who are on blood thinners. The goal is to see if this therapy improves recovery compared to a placebo after reversing the blood thinner's effects.

Ischaemic Stroke3-6 monthsEfficacy phase (II)≤5 visitsStandard MedicinesPartially RemoteInternal MedicineNeurology

Glaucoma: Oral Semaglutide Study

We are investigating whether oral semaglutide can safely improve retinal function in patients with open-angle glaucoma. This research may help find new ways to protect vision in those affected by this condition.

Glaucoma>2 yearsMonitoring phase (IV)≤5 visitsStandard MedicinesCost ReimbursementEndocrinologyOphthalmology

Allergic Rhinitis: New Immunotherapy Treatment

We are studying a new subcutaneous immunotherapy for patients with allergic rhinitis or rhinoconjunctivitis, with or without asthma. The goal is to evaluate its safety and effectiveness compared to a placebo.

Moderate to Severe Allergic Rhinitis with or without Asthma1-2 yearsEfficacy phase (II)Standard MedicinesAllergologyInternal Medicine

Myoclonic Astatic Epilepsy: Fenfluramine Safety Study

We are monitoring the long-term safety of Fenfluramine as an add-on therapy for patients with Myoclonic Astatic Epilepsy. This study aims to ensure the treatment is safe and effective for managing seizures.

Myoclonic-Astatic Epilepsy>2 yearsEfficacy phase (II)Post-Trial Drug AccessNo PlaceboStandard MedicinesNeurology

Metastatic Colorectal Cancer: Cetuximab Treatment Study

We are exploring a new treatment approach using cetuximab for patients with specific genetic markers in metastatic colorectal cancer. The study aims to understand its effectiveness, safety, and impact on quality of life.

Metastatic Colorectal Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

Colonoscopy Prep: Comparing Plenvu® and Picoprep®

We are studying how well Plenvu® works compared to Picoprep® for cleaning the bowel before a colonoscopy. The goal is to see which option is more effective and easier for patients to tolerate.

Healthy Participants for Colonoscopy Preparation>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesGastroenterology

Turner Syndrome: Oral vs. Transdermal Estrogen

We are studying whether oral and transdermal estrogen treatments provide similar benefits for women with Turner Syndrome. This research may help tailor hormone therapy to individual needs.

Turner's Syndrome≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesEndocrinologyGynecology and Obstetrics

Antibiotic Levels in Pregnant Women with Twins

We are studying how antibiotics are processed in mothers of twins and their newborns. This research may help improve treatment safety and effectiveness for both mothers and babies.

Pregnancy≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesGynecology and ObstetricsInfectious Diseases

Hematopoietic Cell Transplantation: Comparing Conditioning Regimens

We are comparing two treatment methods for patients receiving stem cell transplants from matched donors. The goal is to see if one method improves recovery rates better than the other.

Hematological Malignancies>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesHematologyOncology

Ulcerative Rectal Colitis: Tofacitinib Response Study

We are researching what factors may predict how well patients with ulcerative rectal colitis respond to Tofacitinib therapy. This could help improve treatment strategies for better patient care.

Ulcerative Colitis>2 yearsMonitoring phase (IV)6-10 visitsPost-Trial Drug AccessNo PlaceboStandard MedicinesGastroenterologyInternal Medicine

Mycobacterium Avium Complex Lung Infections: Comparing Antibiotics

We are studying whether azithromycin is as effective as clarithromycin for treating lung infections caused by Mycobacterium avium complex. The trial also examines safety and side effects of both treatments.

Mycobacterium Avium Complex Infection>2 yearsConfirmation phase (III)6-10 visitsNo PlaceboStandard MedicinesInfectious DiseasesPulmonology

Steroid Withdrawal in Systemic Lupus Erythematosus (SLE)

We are studying whether stopping glucocorticoids is as effective as continuing a low dose for patients with stable SLE. This research aims to understand the impact on disease activity and quality of life over three years.

Systemic Lupus Erythematosus>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInternal MedicineRheumatology

Bloodstream Infections: PipEracillin Tazobactam vs. Meropenem

We are studying whether PipEracillin Tazobactam is as effective as Meropenem for treating bloodstream infections caused by certain resistant bacteria. This trial is for patients with infections from these specific bacteria.

Bacteremia1-2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesInfectious DiseasesInternal Medicine

Hydroxychloroquine for Mastocytosis Symptoms

We are studying whether hydroxychloroquine can help reduce itching and flushing in patients with isolated cutaneous mastocytosis or indolent systemic mastocytosis with skin involvement. The trial also looks at other symptoms and how well patients tolerate the treatment.

Mastocytosis>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesDermatologyInternal Medicine