Search Clinical Trials in the European Union

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1661-1680 of 1,782 trials

Atrial Fibrillation Prevention: Landiolol Hydrochloride

We are studying whether Landiolol hydrochloride can help prevent atrial fibrillation in patients undergoing heart surgery. This trial looks at how often this condition occurs in the days following the surgery.

Normal Heart RhythmNormal Ejection FractionBeta-blocker Use≤3 monthsConfirmation phase (III)6-10 visitsStandard MedicinesCardiologyInternal Medicine

Advanced Colorectal Cancer: FOLFIRI and Cetuximab Treatment

We are studying whether a combination of FOLFIRI and Cetuximab is effective for patients with advanced colorectal cancer who have specific genetic markers. This research aims to improve first-line treatment options for these patients.

Metastatic Colorectal Cancer>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesOncology

X-ALD: Pramipexole for Leg Symptoms

We are investigating whether pramipexole can help reduce restless leg symptoms in women with X-linked Adrenoleukodystrophy. This study aims to improve their sleep and walking performance.

X-linked AdrenoleukodystrophyRestless Legs Syndrome3-6 monthsMonitoring phase (IV)11-15 visitsNo PlaceboStandard MedicinesCost ReimbursementPartially RemoteNeurology

Advanced Clear-Cell Renal Carcinoma: Digital Monitoring with Cabozantinib and Nivolumab

We are studying how digital tracking of symptoms can help adjust treatments for patients with advanced clear-cell renal carcinoma receiving Cabozantinib and Nivolumab. This may improve their overall health and quality of life during treatment.

Kidney Cancer>2 yearsMonitoring phase (IV)16-20 visitsNo PlaceboStandard MedicinesPartially RemoteInternal MedicineOncologyUrology

Locally Advanced Rectal Cancer: NeoAspMet Trial

We are studying whether adding aspirin or metformin to standard chemotherapy improves tumor response in patients with locally advanced rectal cancer. This trial aims to see if these treatments can lead to better outcomes compared to standard care.

Locally Advanced Rectal CancerEfficacy phase (II)Confirmation phase (III)No PlaceboStandard MedicinesOncology

Basal Cell Carcinoma: Electrochemotherapy vs. Radiotherapy

We are comparing a new treatment called electrochemotherapy with standard radiotherapy for small basal cell carcinomas. The study will also assess side effects, appearance after treatment, and patient satisfaction.

Basal Cell Carcinoma>2 yearsMonitoring phase (IV)No PlaceboStandard MedicinesDermatologyOncology

Gastric Cancer: Pre-operative Treatment with Capecitabine and Atezolizumab

We are studying a combination of chemotherapy and immunotherapy for patients with resectable gastric and GE-junction cancer. The goal is to see if this treatment is safe and effective in shrinking tumors before surgery.

Gastric Cancer3-6 monthsEfficacy phase (II)No PlaceboStandard MedicinesGastroenterologyOncology

TryptoBPH: Tryptophan for Benign Prostatic Hyperplasia

We are studying whether tryptophan can improve urinary symptoms in men with benign prostatic hyperplasia. The trial will also look at its effects on prostate size and quality of life.

Benign Prostatic Hyperplasia6-12 monthsEfficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesInternal MedicineUrology

Esketamine for Schizophrenia Symptoms

We are studying whether esketamine can reduce depressive and negative symptoms in people with schizophrenia. The trial also looks at whether it causes any worsening of psychotic symptoms.

Negative and Depressive Symptoms in Schizophrenia and Schizoaffective Disorder≤3 monthsConfirmation phase (III)6-10 visitsStandard MedicinesPsychiatry

High-Risk Thyroid Cancer: Neoadjuvant Pembrolizumab Study

We are studying the effects of pembrolizumab as a pre-surgery treatment for patients with high-risk thyroid cancers. The goal is to see if it improves outcomes and understand how the body responds to this therapy.

Thyroid CancerEfficacy phase (II)No PlaceboStandard MedicinesEndocrinologyOncology

Testosterone Gel for Improving Recovery in Critically Ill Patients

We are studying whether daily testosterone gel can enhance physical performance and recovery in men and women during critical illness. This trial compares the gel to a placebo to see if it helps patients recover better after ICU admission.

Invasive Mechanical VentilationEfficacy phase (II)Standard MedicinesCost ReimbursementEndocrinologyInternal Medicine

Advanced Solid Tumors: Testing IPN01195

We are studying a new medicine called IPN01195 to see how safe it is and what the best dose is for adults with advanced solid tumors. This trial aims to understand its effects on tumor activity and how it works in the body.

Advanced Solid Tumour3-6 monthsSafety phase (I)Efficacy phase (II)≤5 visitsNo PlaceboStandard MedicinesCost ReimbursementOncology

Staphylococcus Aureus Bacteremia: Comparing Antibiotic Durations

We are studying whether 7 days of antibiotic treatment is as effective as 14 days for patients with uncomplicated Staphylococcus aureus bacteremia. This may help reduce antibiotic use and hospital stays.

Staphylococcus aureus Bacteremia≤3 monthsMonitoring phase (IV)No PlaceboStandard MedicinesInfectious DiseasesInternal Medicine

AL Amyloidosis: Teclistamab Treatment Study

We are investigating whether teclistamab can improve blood health in patients with previously treated AL amyloidosis. This study will also look at the treatment's safety and its effects on quality of life.

Amyloid Light-Chain Amyloidosis>2 yearsEfficacy phase (II)No PlaceboStandard MedicinesHematologyOncology

Neoadjuvant Chemo-Immunotherapy for Stage III PD-L1 Positive NSCLC

We are studying a combination of tislelizumab and chemotherapy for patients with stage III PD-L1 positive lung cancer. The aim is to see if this treatment improves surgery success and survival rates.

Stage III Non-Small Cell Lung CancerEfficacy phase (II)No PlaceboStandard MedicinesPartially RemoteOncologyPulmonology

Ravulizumab Dosing for PNH Patients

We are studying whether personalized dosing of ravulizumab is more effective than standard dosing for adults with PNH. This trial also looks at patient preferences and treatment costs.

Paroxysmal Nocturnal Hemoglobinuria1-2 yearsMonitoring phase (IV)Post-Trial Drug AccessNo PlaceboStandard MedicinesHematologyInternal Medicine

Atrial Fibrillation: Flecainide vs. Amiodarone

We are studying whether flecainide is more effective and safe than amiodarone for treating paroxysmal atrial fibrillation in patients with coronary disease. This trial aims to see if it can restore normal heart rhythm faster and reduce hospital visits.

Coronary Artery DiseaseParoxysmal Atrial Fibrillation>2 yearsConfirmation phase (III)No PlaceboStandard MedicinesCardiologyInternal Medicine

Ketamine for Depression: Brain Imaging Study

We are investigating how different forms of ketamine affect brain function in individuals with depression. This study aims to improve our understanding of how ketamine may help in treating this condition.

Healthy Participants>2 yearsSafety phase (I)Standard MedicinesPsychiatry

Glioblastoma Multiforme: Itraconazole with Radiotherapy and Temozolomide

We are studying whether adding Itraconazole to standard radiotherapy and temozolomide is safe for patients with newly diagnosed glioblastoma. Our goal is to find the best dose and understand its effects on survival and quality of life.

Glioblastoma≤3 monthsSafety phase (I)6-10 visitsNo PlaceboStandard MedicinesNeurologyOncology

Crohn's Disease in Children: Budesonide Treatment

We are studying a topical treatment with budesonide for children with Crohn's disease affecting the esophagus, stomach, or duodenum. The goal is to see if it helps reduce inflammation in these areas.

Crohn's Disease≤3 monthsConfirmation phase (III)No PlaceboStandard MedicinesGastroenterologyPediatrics